Navigation Links
Researchers reveal function of novel molecule that underlies human deafness
Date:1/21/2011

New research from the University of Sheffield has revealed that the molecular mechanism underlying deafness is caused by a mutation of a specific microRNA called miR-96. The discovery could provide the basis for treating progressive hearing loss and deafness.

The research team, led by Dr Walter Marcotti, Royal Society University Research Fellow from the University's Department of Biomedical Science, in collaboration with Professor Karen Steel at the Sanger Institute in Cambridge, discovered that the mutation in miR-96 prevents development of the auditory sensory hair cells. These cells are located in the inner ear and are essential for encoding sound as electrical signals that are then sent to the brain.

The research has been published this week in the Proceedings of the National Academy of Sciences journal and was based on studies of mice, which do not normally hear until about 12 days after birth. Prior to this age their immature hair cells must execute a precise genetic program that regulates the development of distinct types of sensory hair cell, namely inner and outer hair cells.

The research teams found that in a strain of mice called diminuendo - which carry a single base mutation in the miR-96 gene - hair cell development is arrested around birth.

The study shows that miR-96 normally regulates hair cell development by influencing the expression of many different genes associated with a wide range of developmental processes at a specific stage. The researchers discovered that the mutation hinders the development not only of the mechanically sensitive hair bundle on the cell apex but also the synaptic structures at the base that govern transfer of electrical information to the sensory nerves. These new findings suggest that miR-96 is a master regulator responsible for coordinating the development of the sensory cells that are vital to hearing.

Since the mutation in miR-96 is known to cause human deafness and microRNA molecules can be targeted by drugs, the work also raises new opportunities for developing treatments to treat hearing loss.

Dr Walter Marcotti said: "Progressive hearing loss affects a large proportion of the human population, including new born and young children. Despite the relevance of this problem, very little is currently known regarding the genetic basis of progressive hearing loss. Our research has provided new and exciting results that further our understanding of auditory development as well as possible molecular targets for the development of future therapies."


'/>"/>

Contact: Shemina Davis, Media Relations Officer
shemina.davis@sheffield.ac.uk
01-142-225-339
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... WA (PRWEB) , ... May ... ... a full service insurance provider serving families of Camas and Vancouver, WA, ... current campaign fundraises for the National Breast Cancer Foundation and their Mammography ...
(Date:5/4/2016)... ... May 04, 2016 , ... The RIDER Institute announces an ... DRACO broad-spectrum antiviral therapeutics. DRACOs have proven effective against all 18 viruses tested ... at http://igg.me/at/EndTheVirus and runs for 60 days, we are raising new ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nike Rugby Camp's success is due in ... Willis, founder of Elite Rugby Camps and current Nike Camp director, has offered an ... 2009. , ā€œIā€™m excited for our eighth summer here in San Diego,ā€ says ...
(Date:5/4/2016)... ... May 04, 2016 , ... All-Star ... created to assist the people of their local community. The agency pledges to ... community leaders. Their hope is to bring awareness to important local causes with ...
(Date:5/4/2016)... CA (PRWEB) , ... May 04, 2016 , ... Dr. ... offering wisdom tooth removal surgery at their office. Wisdom tooth removal, a common dental ... not always problematic, they often are improperly erupted, resulting in risks of complications. By ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... DUBLIN , May 4, 2016 ... the "Global Cancer Stem Cell Therapy Market Outlook ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has ... therapeutics are expected to be developed in coming years. ... these techniques. Cancer stem cell therapies are also expected ...
(Date:5/3/2016)... , May 3, 2016  As a teenager, ... contracted rheumatic fever, which damaged his heart. He continued ... But by June 2013, Shepherd,s heart was giving out ... death. On June 20, 2013, the Mesa, ... Artificial Heart (TAH-t). Like a heart transplant, the SynCardia ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
Breaking Medicine Technology: