Navigation Links
Researchers reveal crucial immune fighter role of the STING protein
Date:6/18/2012

NEW YORK (June 15, 2012) -- Researchers at Weill Cornell Medical College have unlocked the structure of a key protein that, when sensing certain viruses and bacteria, triggers the body's immediate immune response.

In the journal Molecular Cell, scientists describe the double wing-like crystal structure of this key protein, known as STING, which is a soldier on the front-line of the body's defense against pathogens. Researchers also show STING in action, displaying evidence of a bacterial infection -- an action that launches the body's innate immune response.

"Activation of STING is crucial to the ability of the human body to pick out bits of molecules secreted by pathogens, including many different viruses and bacteria, and alert the human body that they are there. By solving the structure of this protein, we now know how they do this crucial task," says the study's lead author, Dr. Qian Yin, a postdoctoral associate in the laboratory of Dr. Hao Wu, professor of Biochemistry at Weill Cornell Medical College.

"The STING structure provides a remarkable example of the pathogen-host interactions in which a unique microbial molecule directly engages the innate immune system," says Dr. Wu, the study's senior investigator and director of the Lab of Cell Signaling at Weill Cornell.

While the findings have no immediate clinical significance, they might be useful in helping to make vaccines against pathogens more effective. "Based on the structure we have of STING interacting with molecules secreted from bacteria, we may be able to design new molecules that induce a stronger, more persistent immune response," says Dr. Yin.

STING's wings and tail respond to invaders

All plant and animal life use an innate immune response to recognize and respond to an assault by pathogens. This primitive response is immediate, but not long-lasting or protective; the secondary, adaptive immune response sets up the long-term defen
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... The click strand woven bamboo flooring ... the business announces a click strand woven bamboo ... 2015. , Click strand woven bamboo flooring replicates ... well-known brand in the bamboo industry. It promises ... bamboo flooring supplier. , “We are happy to ...
(Date:12/25/2014)... the popular online supplier of wedding dresses and special occasion ... black one-shoulder cocktail dresses . In addition, all these elegant ... prices, up to 70% off. , The development ... You know, we have thousands of frequent callers in the ... can visit our website for more details. The current special ...
(Date:12/25/2014)... 25, 2014 Helen Harris’ RP (Retinitis ... Hills, California after an 8 year battle with breast ... Eve evening in her home in Woodland Hills California ... cancer. , As the founder and ... she pioneered and championed many of today's greatest breakthroughs ...
(Date:12/25/2014)... Overeating is common during the holidays, but there are strategies ... "Don,t arrive at a party hungry. It may seem ... attending a party, but deprivation leads to hunger, and hunger ... Hospital in Mount Kisco, N.Y., said in a hospital news ... and even to have a snack before attending a party ...
(Date:12/25/2014)... “ SmileStix ” was featured on NewsWatch as part ... mobile applications on the iOS, Android, and Windows markets. Andrew ... the app review and shared with viewers how this is ... old saying goes, “A picture says a thousand words.” It’s ... a single image, because each picture holds a unique and ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... ... on a brand new buy back plan. , ... (PRWEB) – CosmeticLaserWorld.com ( www.cosmeticlaserworld.com ), a market leader ... spas should purchase equipment from the reseller. Under an Investment Protection Plan, the company ...
... , Transplant surgeons at Johns Hopkins who have reviewed the ... that it is not simply racial differences, but rather flaws ... and education levels, in addition to biological factors, that are ... in African Americans. In a report on the review ...
... for men with advanced disease, researchers say , MONDAY, May ... Provenge, is safe and has few side effects, a new ... Administration approved the vaccine for use in men with advanced ... approved based on both safety and clinical data," said lead ...
... ... man , ... May 31, 2010 -- Those seeking to obtain ultimate health should take a page from ... experiencing several illnesses in previous years and now walking in health, the author penned the ...
... of cesarean births in British Columbia were a result of ... deliveries varied widely across health regions in B.C., according to ... "There is a misconception that the overall increase of cesarean ... Gillian Hanley, a PhD student in the UBC School of ...
... reduce discomfort, scientists say , SUNDAY, May 30 ... may help relieve pain by triggering a natural painkilling ... The researchers also believe they can enhance acupuncture,s effectiveness ... -- deoxycoformycin -- that maintains adenosine levels longer than ...
Cached Medicine News:Health News:CosmeticLaserWorld.com Gives Buyers Peace of Mind Through Industry-Leading Investment Protection Plan 2Health News:Lack of private insurance contribute to higher deaths among black heart transplant patients 2Health News:Lack of private insurance contribute to higher deaths among black heart transplant patients 3Health News:Lack of private insurance contribute to higher deaths among black heart transplant patients 4Health News:Prostate Cancer Vaccine Shows Few Side Effects 2Health News:Prostate Cancer Vaccine Shows Few Side Effects 3Health News:Obtain Ultimate Health from Tips in New Xulon Press Title 2Health News:Regional differences in C-section rate not a result of maternal request: UBC study 2Health News:Acupuncture May Trigger Natural Painkiller 2
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., ... developing the proprietary Natural Killer (NK) cell-line platform, ... Dr. Patrick Soon-Shiong , NantWorks founder, physician ... definitive agreement to purchase approximately $48 million of ... with the investment, he will be named Co-Chairman ...
(Date:12/24/2014)... , Dec. 23, 2014 Echo Therapeutics, ... device company focused on skin permeation, continuous glucose ... Scott W. Hollander has been appointed Chief ... has more than 20 years of experience in ... and most recently served as Vice President, Business ...
(Date:12/24/2014)... Dec. 23, 2014   Assurex Health, a ... to healthcare providers for behavioral health and chronic ... $30 million in equity financing from new and ... , President and Chief Executive Officer. ... development of Assurex Health,s GeneSight ® ...
Breaking Medicine Technology:Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4
... system is the lowest profile plate clinically ... integrated lock mechanism, which is designed to ... appreciate the narrow width, which decreases the ... system also offers easy to use instrumentation ...
... supplies, and all patient follow-ups. This allows your ... patient up in your office (analogous to putting ... component, for interpreting the reports PDSHEART provides you. ... full access to your reports 24 hours per ...
... leading provider of Telemedicine monitoring and ... outstanding service commitment to patients and ... transtelephonic testing devices that provide enhanced ... using standard telephone lines. TransMedEx's product ...
... Raytel Cardiac Services is a ... uniquely qualified people, combined with state-of-the-art ... clinical information that supports healthcare professionals ... Cardiac Services uses telecommunications and ECG ...
Medicine Products: