Navigation Links
Researchers reveal aggressive breast cancer's metastatic path
Date:1/14/2013

NEW YORK (Jan. 14, 2013) -- Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor and metastasize throughout the body. Their findings, published in Cancer Cell, suggest a novel approach for developing agents to treat cancer once it has spread.

"Metastasis can be lethal, and our findings point to potential targeted treatments to stop the spread of this aggressive breast cancer," says the study's senior investigator, Dr. Vivek Mittal, an associate professor of cell and developmental biology and director of the Lehman Brothers Lung Cancer Laboratory at Weill Cornell Medical College.

According to researchers, if such agents were developed, they would perhaps be the first to specifically treat cancer metastasis, importantly in patients whose tumors have already spread. They would also be among the first designed to restore the function of a microRNA (miRNA), a small, non-coding RNA that regulates gene expression, which is crucial to cancer spread. While distinct miRNA "signatures" have been found for many tumor types, including different breast cancers, their specific roles in later steps of cancer metastasis has been unclear, Dr. Mittal says.

In the study, researchers set out to identify a miRNA that impacts metastasis without affecting primary tumor growth, as well as address its underlying molecular mechanisms and therapeutic potential against metastatic breast cancer. They discovered that a miRNA known as miR-708 is inhibited in metastatic triple negative breast cancer. They found that miR-708 acts as a metastatic tumor inhibitor, and when its function is restored, the tumors do not spread or form lethal macrometastases.

Silenced miRNA Inhibitor Molecule Can Be Switched Back On

Triple negative breast cancer has the worst outcome of all b
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... Alzheimer,s researchers failed to replicate what appeared to be ... when they were published last year in the journal ... 9, 2012, suggested that the drug bexarotene (marketed as ... plaques (Aβ) a pathological hallmark of Alzheimer,s disease ... authors of the 2012 report, drug treatment quickly removed ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Amirsys today ... exciting new enhancements for instructors and students. Instructors can ... focused through personalize learning plan templates, targeted reading assignments, ... provides 500 new assessment questions, 5,000 searchable anatomy glossary ... , AnatomyOne 2.0 is the first gross ...
(Date:5/24/2013)... CA (PRWEB) May 24, 2013 Mr. ... present the 3rd Annual EB-5 Investment Summit: Dealmakers Conference ... Dealmakers Conference will focus on exploring alternative finance through ... latest market, legal and economic information, and updates to ... within the EB-5 industry. , "Our goal is ...
(Date:5/24/2013)... 24, 2013 Dwell Media LLC ... Huff as Executive Vice President of Digital for Dwell ... which represented a large portion of Yahoo's global media ... Dwell develops a fully-integrated commerce unit to launch in ... monetizing digital content for leading firms in Silicon Valley. ...
(Date:5/24/2013)... 24, 2013 Mike Stoler believes that ... successful business people in New York. That’s why ... weekly on CUNY TV. And that’s why he ... Allergy Associates, LLP (ENTA)—the largest single specialty practice in ... throat, allergy and audiology specialists and sub-specialists service communities ...
Breaking Medicine News(10 mins):Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Amirsys AnatomyOne 2.0 Delivers Personalized Learning Plans 2Health News:Brian Su Organizes 3rd Annual EB-5 Investment Conference in Long Beach, California 2Health News:Yahoo Commerce Head Joins Leadership at Dwell Media 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 2Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 3Health News:Robert Glazer, Chief Executive Officer of ENT and Allergy Associates, LLP®, Talks About the Business of Succeeding in New York 4
... transmitted by the tiny sand fly, has affected an estimated 25,000 ... The disease has got 31 of the state's 38 districts in ... it affects the poorest of the poor, the disease has affected ... Patna. Manjhi is desperate to earn more money to treat his ...
... park and a vaccine park in Chennai soon to help ... research into new vaccines, said Health Minister Anbumani Ramadoss. ... medical equipment for the country, the vaccine park will research ... medical park will be built on 300 acres of land ...
... their proteins go unfolded. It's a reaction with a ... ,Now, new research from Rockefeller University shows that ... a sign that the cell has given up, it ... with adversity. ,Diabetes, cancer, and neurodegenerative diseases ...
... new study that takes a rare look at the physiological, ... shows that when older adults go to bed lonely, sad ... waking the next morning. ,Elevated levels of cortisol ... health problems when chronic -- actually cue the body on ...
... has discovered a target site within malaria-carrying mosquitoes that ... to the Anopheles gambiae mosquito and other mosquito species. ... supported by further studies, the findings could offer a ... as malaria. , ,Yuan-Ping Pang, Ph.D., a ...
... a protein's role in the immune system have revealed ... in approximately one percent of all live births//. ... impairs the ureter’s ability to pump urine from the ... Ph.D., assistant professor of pathology and immunology. "If untreated, ...
Cached Medicine News:Health News:Kalaazar sweeping through Bihar, 93 dead 2Health News:India to set up medical and vaccine parks: Ramadoss 2Health News:Unfolded Proteins May Protect Cells from Dying 2Health News:Adults Who Go to Bed Lonely Get Stress Hormone Boost Next Morning 2Health News:Adults Who Go to Bed Lonely Get Stress Hormone Boost Next Morning 3Health News:Mayo Researcher Discovers Target Site for Developing Mosquito Pesticides 2Health News:Mayo Researcher Discovers Target Site for Developing Mosquito Pesticides 3Health News:Protein Essential for Kidney-to-Bladder Urine Transfer 2Health News:Protein Essential for Kidney-to-Bladder Urine Transfer 3
(Date:5/24/2013)... 2013  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ... the Deutsche Bank Health Care Conference to be held ... Adrian Adams , Chief Executive Officer ... the Company and its product pipeline at 12:00 p.m. ... (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation will ...
(Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
(Date:5/23/2013)... BRAINTREE, Mass. , May 23, 2013  Haemonetics Corporation ... Chris Lindop , CFO & EVP-Business Development, will present ... Care Conference in Boston, MA on ... (Logo: http://photos.prnewswire.com/prnh/20120206/NE47232LOGO ) The public may ... About Haemonetics Haemonetics (NYSE: ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 43SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... rotary microtome, designed for fully motorized ... specimens, offers a broad application spectrum ... laboratory. This microtome meets the requirements ... fully motorized/electronic microtome for their laboratory. ...
... microtome with automatic fine/trim- feed system, ... precision cross roller bearings. For sectioning ... in biological, botany, and materials science. ... 90 mm can be accommodated. Performance, ...
... fixed and unfixed tissue in histology and neurology ... science The HM 650 V offers an ... 1,2 mm and frequency between 30 and 100 ... each other. All parameters can be set via ...
... Leica Microsystems offers a fully automated ... is designed to coverslip microscope glass ... smears. The instrument accepts quality-grade coverslips ... common mounting media. The capability of ...
Medicine Products: