Navigation Links
Researchers report potential new treatment to stop Alzheimer's disease
Date:11/15/2012

earchers, working first in cell cultures, found that CLR01 effectively inhibited a process known as synaptotoxicity, in which clumps of toxic amyloid damage or destroy a neuron's synapses.

Even though synapses in transgenic mice with Alzheimer's may shut down and the mice may lose their memory, upon treatment, they form new synapses and regain their learning and memory abilities.

"For humans, unfortunately, the situation is more problematic because the neurons gradually die in Alzheimer's disease," Bitan said. "That's why we must start treating as early as possible. The good news is that the molecular tweezers appear to have a high safety margin, so they may be suitable for prophylactic treatment starting long before the onset of the disease."

Next, using a radioactive "label," the researchers were able to confirm that the compound had crossed the mouse's bloodbrain barrier and was effective in clearing the brain of amyloid-beta and tau aggregates.

"This work shows that molecular tweezers do a number of things they help to ameliorate multiple pathologic features of Alzheimer's, including amyloid plaques, neurofibrillary tangles and brain inflammation, and our cell culture experiments demonstrated that molecular tweezers block the toxic effect of amyloid-beta on synaptic integrity and communication," Bitan said.

"We call these unique tweezers 'process-specific,' rather than the common protein-specific inhibitors," he added, meaning the compound only attacks the targeted toxic aggregates and not normal body processes. "That's a big deal, because it helps confirm evidence that the molecular tweezers can be used safely, ultimately supporting their development as a therapy for humans."

The next step, Bitan hopes, is to confirm that the tweezers improve memory and not just brain pathology. The researchers say they are working on this question and already have encouraging preliminary data.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Feinstein Institute researchers discover plant derivative
2. Sociology, economics researchers receive grant to study development across the human lifespan
3. Genital Injuries Common But Preventable, Researchers Say
4. Researchers identify impact of rheumatoid arthritis and lupus on joint replacement surgery outcomes
5. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
6. Researchers find why nicotine in cigarettes may relieve anxiety in smokers
7. Researchers develop non-invasive technique for predicting patients response to chemotherapy
8. Researchers explore connection between popular pain relievers, bladder cancer
9. Researchers discover immune pathway
10. Temple researchers show targeted cancer drug may stunt hearts ability to repair itself
11. Researchers discover how underground rodent wards off cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... Jusuru International has been awarded the prestigious ... its flagship nutritional supplement, Liquid BioCell™ Life, and the ... new logo, new packaging, new products, and new messaging. ... identify and promote programs that serve as examples of ... Jusuru International for their outstanding accomplishments and contributions to ...
(Date:5/1/2015)... May 01, 2015 TROY Healthcare Solutions ... Southeast Regional User Group (RUG) Conference in Atlanta, GA ... Regional User Group Conference provides a forum for client-to-client ... support all aspects of electronic medical record operations, as ... software applications. , In addition to sponsoring the event, ...
(Date:5/1/2015)... Ernst & Young (EY) has announced ... & CSO, and Burak Sezen, Co-Founder & CTO of ... Entrepreneur Of The Year® 2015 Awards in the Ohio ... a global leader in assurance, tax, transaction and advisory ... the top audit companies in the world. The awards ...
(Date:5/1/2015)... 2015 Today the United Nations Foundation’s Girl ... efforts to help protect the rights of adolescent girls in ... country added since Girl Up began almost five years ago ... supporting adolescent girls in the Rajasthan region of India. ... the advancement of adolescent girls in Guatemala, Ethiopia, Liberia, and ...
(Date:5/1/2015)... 01, 2015 The frozen yogurt chain ... Hickory Crawdads (NC) and the Myrtle Beach Pellicans (SC). ... concession locations and offer fans discounts at local sweetFrog ... Hickory Community,” said Luke Shook, co-owner of the Hickory ... and we look forward to enjoying the games and ...
Breaking Medicine News(10 mins):Health News:Jusuru International Receives 2015 DSA Ethos Award 2Health News:Jusuru International Receives 2015 DSA Ethos Award 3Health News:Jusuru International Receives 2015 DSA Ethos Award 4Health News:Jusuru International Receives 2015 DSA Ethos Award 5Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 3Health News:RowdMap, Inc. Named as a Ernst & Young Entrepreneur Of The Year® 2015 Award Finalist 2Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 2Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 3Health News:sweetFrog Announces Minor League Baseball Partnerships 2
... at the San Francisco's 2002 Gay Pride, San Francisco Department ... syphilis testing. ,In the above said campaign, a ... encouraging the many hundreds of homo whores who had gathered ... ,Although many were not happy with the Ad and ...
... habits, is easily acquired but quite difficult to stop.// All ... or at least have to try out recommended smoking cessation ... the ages of 16 and 24 years do try to ... try out tested methods. ,An article presented in ...
... developed a weight reduction pill, which works better and faster ... heart disease, diabetes and cancer. ,Existing anti-obesity pills ... for a year. ,But men and women taking ... for 48 weeks lost 12 percent of their body weight, ...
... add variety from Himachal Pradesh.// ,The strawberry wine was ... and wine processing plant in Mandi district, 180 km from ... research by experts and will be called Kalpa wine, named ... some of the best wines in the country. ...
... sclerosis (SSc) is a chronic autoimmune disorder marked ... fibrosis.// More than skin deep, this thickening and ... the gastrointestinal tract, the lungs, and the heart. ... dysfunction, serious illness, and death. Researchers have yet ...
... for patients in ICU by adhering to simple techniques ... infections. ICUs can become thoroughly aseptic by ensuring a ... catheters. A detailed report was made by experts on ... report are published in New England Journal of Medicine. ...
Cached Medicine News:Health News:Tried To Quit Smoking And Failed? Call 1-800-QUIT-NOW 2Health News:New Treatment Offers Hope for Systemic Sclerosis 2Health News:Simple Steps to Safe Guard Patients from Bloodstream Infections in ICU 2
(Date:5/1/2015)... 2015  Misonix, Inc. (NASDAQ: MSON ), ... and markets innovative therapeutic ultrasonic products for spine ... laparoscopic surgery and other surgical applications, announced today ... third quarter fiscal year 2015 on Thursday, May ... call that same day, Thursday, May 7, 2015, ...
(Date:4/30/2015)... April 30, 2015 Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the fourth ... Fourth quarter and fiscal 2015 overview: , ... fourth quarter, up 33% over last year,s comparable quarter, ... , Diluted EPS of $0.50 for the fourth ...
(Date:4/30/2015)... 2015  Thoratec Corporation (NASDAQ: THOR ), a ... support and restore failing hearts, said today it will ... Healthcare Conference on Thursday, May 14. ... will provide an update on the company, beginning at ... Time). The presentation will be available through ...
Breaking Medicine Technology:Misonix, Inc. To Report Third Quarter Fiscal Year 2015 Financial Results On Thursday, May 7, 2015 2Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 2Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 3Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 4Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 5Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 6Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 7Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 8Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 9Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 10Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 11Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 12Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 13Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 14Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 15Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 16Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 17Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 18Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 19Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 20Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 21Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 22Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 23Abaxis Reports Financial Performance for the Fourth Quarter and Fiscal 2015 and Declares a 10% Increase in Quarterly Cash Dividend 24Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2
... 11 CryoLife, Inc. (NYSE: CRY ), ... announced today that Steven G. Anderson, president and chief executive ... upcoming Lazard Capital Markets Sixth Annual Healthcare Conference on Wednesday, ... City. CryoLife,s live presentation may be accessed through its ...
... PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), today ... MuGard, an FDA approved treatment for oral mucositis, a debilitating ... to commercially launch MuGard in North America in the first ... launch include: , Manufacturing : Access is ...
Cached Medicine Technology:CryoLife to Present at Upcoming Investor Conferences in New York 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch in North America 4
... Finnpipette Focus multichannel pipettes ... of reagents into microplates, ... 0.1-10 l volumes. The ... Finnpipette Focus multichannels, combined ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
The Biopette E has a comfortable, ergonomic design. Fully motorized piston drive. Virtually eliminates pipetting forces. User-friendly operator interface. Simple, precise volume setting. Rechargelabl...
... best value in high performance electronic pipetting!, ... design reduce hand fatigue and strain , ... ejector , Color coding for easy volume ... greater performance use Hamilton AdvanTip Low Retention ...
Medicine Products: