Navigation Links
Researchers report no difference in breast cancer characteristics after oophorectomy

CHICAGO, IL. (May 28, 2010)More than half a million women in the United States undergo a hysterectomy each year and approximately half of those surgeries include removal of the ovaries. Researchers know that removing a woman's ovaries is associated with a reduction in the risk of developing breast cancer, but it has not been clear whether those cancers that do arise in these women differ from breast cancers in the general population. Now, investigators at Fox Chase Cancer Center report that women who have had a bilateral oophorectomy tend to have smaller tumors and to have their tumors detected by mammography rather than by physical exam. The use of hormone therapy after surgery, however, wipes out any difference in tumor size or detection method.

The investigators, led by James R. Nitzkorski, M.D., a surgical oncology fellow at Fox Chase, will present their results at the 46th Annual Meeting of the American Society of Clinical Oncology on Saturday, June 5.

"It is helpful to know that tumors that develop after bilateral oophorectomy are not necessarily a more aggressive type of disease," Nitzkorski says. "There was no difference in overall survival or in prognostic factors, such as estrogen receptor status, progesterone receptor status, or HER2/neu status between women who had had an oophorectomy or not."

Removal of a woman's ovaries is associated with an 11% decrease in lifetime risk of breast cancer (the risk reduction associated with the surgery climbs to about 50% in women with a BRCA1/2 mutation). Given that reduction in risk, Nitzkorski and colleagues initially hypothesized that the tumors that do develop in women after a bilateral oophorectomy might be worse than the tumors that arise in the general population because they had to overcome the protective environment that exists in the absence of ovariesthat was not the case.

"I think women can be counseled that although they have developed breast cancer in the protective environment of an oophorectomy, we don't expect their cancer will be any better or worse than that of a woman who didn't have an oophorectomy," Nitzkorski says.

To evaluate the impact of ovary removal on breast cancers, the team identified 687 women diagnosed with invasive breast cancer between 2004 and 2008 at Fox Chase and who had a known ovary status. Of these, 71 (10.3%) had undergone a prior bilateral oophorectomy. The women who had had their ovaries removed were significantly more likely to have taken hormone replacement therapy than women who still had their ovaries, 56.3% versus 19.0%.

Tumors in the women who had undergone a bilateral oophorectomy were smaller than those in women who had their ovaries, with a median of 1.3 cm compared with 1.5 cm, which was a statistically significant difference. Additionally, mammographic detection was more common in women who had had their ovaries removed than in women with their ovaries, 69.0% compared with 47.9%, respectively. Although patient's cancer tumor and lymph node staging was accounted for, Nitzkorski and colleagues have not seen any difference in overall survival related to oophorectomy with in their 20 months of follow up


Contact: Diana Quattrone
Fox Chase Cancer Center

Related medicine news :

1. Vanderbilt researchers play major role in new center on electronic health information privacy
2. Pitt researchers discover gene mutation linked to lymphatic dysfunction
3. Researchers validate a new test for assessing childrens and teenagers fitness to prevent morbidity
4. Novel anti-malarial drug candidate found by UT Southwestern researchers
5. Mount Sinai researchers move closer to a universal influenza vaccine
6. MIT researchers develop better way to detect food allergies
7. Crohn's & Colitis Foundation National Event Helping Women Manage Inflammatory Bowel Disease: Two Women Physician Experts and Researchers in IBD on Interactive Webcast/Teleconference
8. Mayo Clinic researchers find gene they believe is key to kidney cancer
9. Researchers get $3.3 million grant to investigate language outcomes of bilingual children
10. Mayo Clinic researchers find genetic secrets to common kidney cancer
11. System that predicts protein structures could help researchers design drugs
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of ... 6, 2016, at Caesars Palace in Las Vegas with a pre-conference session on ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment ... itself for not only fulfilling the needs of advisers and clients but going ... price and providing top-tier customer service. However, there's always room for improvement, which ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... successful and prominent nonprofit healthcare organizations in the country. They have overseen financial ... organizations, and helped advance the healthcare industry as a whole through their advocacy ...
(Date:11/27/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class ... (Long Term Support) into its Q-Suite 5.10 product line. , Making the change ... version of Asterisk that will receive not only security fixes, but feature and ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... eReferral system for diagnostic imaging in the Waterloo region. Using the Ocean Platform, ... Medicine tests directly from their electronic medical record (EMR) without the need for ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
(Date:11/26/2015)... 3D bioprinting market is expected to reach ... by Grand View Research Inc. Rising prevalence of chronic diseases ... is expected to boost the market growth, as 3D bioprinting ... --> 3D bioprinting market is expected to reach ... by Grand View Research Inc. Rising prevalence of chronic diseases ...
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
Breaking Medicine Technology: