Navigation Links
Researchers report first success of targeted therapy in most common non-small cell lung cancer
Date:11/28/2012

BOSTON - A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.

Published online today in The Lancet Oncology, the combination of chemotherapy and the targeted drug selumetinib was more effective than chemotherapy alone in a clinical trial involving patients with a form of non-small cell lung cancer (NSCLC) that carries a mutation in the gene KRAS a variety that represents about 20 percent of all NSCLC cases. Previously, no targeted agent, either alone or in combination with another drug, had proven beneficial in a trial involving patients with this type of NSCLC.

The 87 patients who participated in the new, phase II trial conducted at 67 sites around the world had advanced, KRAS-mutant NSCLC that had failed initial chemotherapy. The participants were randomly assigned to receive either selumetinib and the chemotherapy agent docetaxel or docetaxel alone.

Investigators found that while 37 percent of the patients in the selumetinib group experienced some shrinkage of their tumor, none of the patients in the docetaxel-only group did. Of particular significance, patients receiving selumetinib lived a median of 5.3 months before their cancer began to worsen, compared to 2.1 months for those receiving chemotherapy alone. (Patients in the selumetinib group also survived longer, on average, than those in the docetaxel group 9.4 months compared to 5.2 months but the improvement was not considered statistically significant.)

"Our findings suggest that selumetinib and docetaxel work synergistically each enhancing the effect of the other," says the study's lead author, Pasi A. Janne, MD, PhD, of Dana-Farber. "This opens the possibility that there may finally be a therapeutic strategy
'/>"/>

Contact: Robbin Ray
Robbin_Ray@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. USC, Oxford researchers find high fructose corn syrup-global prevalence of diabetes link
2. Researchers study cry acoustics to determine risk for autism
3. Researchers explore social media as preventative method for infectious diseases
4. New mechanism for cancer progression discovered by UNC and Harvard researchers
5. Researchers identify physiological evidence of chemo brain
6. Researchers find chemical switches for neurodegenerative diseases
7. Release all Tamiflu data as promised, argue researchers
8. Researchers link new molecular culprit to breast cancer progression
9. Researchers discover gender-based differences in Alzheimers disease
10. Researchers find evidence that brain compensates after traumatic injury
11. Researchers find decline in availability and use of key treatment for depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers report first success of targeted therapy in most common non-small cell lung cancer
(Date:5/24/2015)... Raleigh, NC (PRWEB) May 24, 2015 ... published a paper on air quality compliance issues that ... of American workers. Surviving Mesothelioma has just posted an ... it now. , The group found airborne asbestos ... inspection data collected between 1984 and 2011. , “Asbestos ...
(Date:5/24/2015)... New York (PRWEB) May 24, 2015 ... treatment lawsuits ( http://www.testosteronelawsuithub.com/ ) has scheduled its ... progress of the multidistrict litigation. According to court ... District of Illinois, the Conference will be convened ... re: Testosterone Replacement Therapy Product Liability Litigation - ...
(Date:5/24/2015)... Indiana Fiber Network, LLC (IFN), the leading Indiana ... Inc. (MTA) has selected IFN as a fiber transport ... Sales Manager, fiber route diversity and network redundancy are ... MTA with the diverse fiber transport from their Merrillville ... voice carriers located at Henry Street in Indianapolis, IN. ...
(Date:5/24/2015)... Geneva, WI (PRWEB) May 24, 2015 ... Mercy Health System CEO - ... principal and honored at the fourth ... held April 15 at Geneva National ... (by school): ,     -Badger High School, ...
(Date:5/23/2015)... Florida City, FL (PRWEB) May 23, 2015 ... together to build a new playground for Branches Florida City ... destroyed the former play space in 2010. , A large ... then new playground on May 23, 2010 in the middle ... families watched. The fire was later declared arson even though ...
Breaking Medicine News(10 mins):Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 3Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Five Years After Fire, Branches Rebuilds Playground 2
... for Health announces broad agreement on principles for Getting ... Act WASHINGTON, April 30 Today the Markle Foundation ... to investments in health information technology (IT) under the ... care and information technology will meet with government and ...
... for Pulmonary Fibrosis (CPF) is pleased to announce the airing ... Television (CMT),s CMT Insider show on Saturday, May ... interview was taped at the recent "A Night of Burnin, ... late Dennis Linde in Nashville at the Musician,s Hall of ...
... Biogen Idec (NASDAQ: BIIB) today announced data results from ... (MS) Prevention Study In Ongoing Neurologic Surveillance) study, an ... AVONEX MS Prevention Study). Based on the CHAMPS ... who experienced their first clinical MS episode with MRI ...
... today re-issued a series of It,s Not Flu ... preparedness for families, businesses, medical providers, and community groups."Worry and ... planning ahead will," said Jeff Levi, Ph.D., Executive Director of ... to protect ourselves and our families in the event of ...
... Respond to Increasing Support for Men,s Health Issues ... Men,s Health Network applauds Representatives Barron Hill (D-IN) ... 2115, the "Men and Families Health Care Act ... of Men,s Health within the Department of Health ...
... trachomatis is the most common bacterial agent of ... reported infections in the United States each year. ... (CNSI) at UCLA and the David Geffen School of ... for inducing immunity to the infection. The findings could ...
Cached Medicine News:Health News:Meaningful Investment of $19 Billion on Health Information Technology 2Health News:Meaningful Investment of $19 Billion on Health Information Technology 3Health News:Actor James Marsden To Appear on CMT Insider May 2, Talk About Pulmonary Fibrosis 2Health News:Actor James Marsden To Appear on CMT Insider May 2, Talk About Pulmonary Fibrosis 3Health News:First 10-year follow-up shows that treatment with AVONEX leads to long-term benefits in early multiple sclerosis patients 2Health News:Pandemic Flu Preparedness Guides for Families, Businesses, Medical Providers, and Community Groups Released by Trust for America's Health 2Health News:Pandemic Flu Preparedness Guides for Families, Businesses, Medical Providers, and Community Groups Released by Trust for America's Health 3Health News:Pandemic Flu Preparedness Guides for Families, Businesses, Medical Providers, and Community Groups Released by Trust for America's Health 4Health News:Pandemic Flu Preparedness Guides for Families, Businesses, Medical Providers, and Community Groups Released by Trust for America's Health 5Health News:Pandemic Flu Preparedness Guides for Families, Businesses, Medical Providers, and Community Groups Released by Trust for America's Health 6Health News:U.S. Representatives Hill and Murphy Introduce the 'Men and Families Health Care Act of 2009' 2Health News:Researchers design unique method to induce immunity to certain STDs 2Health News:Researchers design unique method to induce immunity to certain STDs 3
(Date:5/22/2015)... COVENTRY, R.I. , May 22, 2015 /PRNewswire/ ... a once-daily central nervous system stimulant indicated for ... available to patients beginning Summer 2015. ... Aptensio XR received approval from the U.S. Food ... XR is an extended-release formulation of methylphenidate capsule ...
(Date:5/22/2015)... REDWOOD CITY, Calif. , May 22, 2015 /PRNewswire/ ... specialty pharmaceutical company focused on the development and commercialization ... breakthrough pain, today announced that interim chief executive officer ... 2015 Healthcare Conference and chief financial officer Tim ... Science Conference. Details of the two presentations are as ...
(Date:5/21/2015)... , May 21, 2015  When Ryan ... the side of his neck, he figured ... a couple weeks off from weight lifting. ... away.                               A series ... was referred to Michel Kliot, MD ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... Used to connect ... an infusion pump, and ... catheter in order to ... use with Laborie Medical ...
Used for suprapubic monitoring of bladder pressures. Suprapubic urodynamic studies avoid the effects of urethral catheterization and eliminate the need for a double bladder puncture. Supplied sterile...
... Cardiac Panel is a fluorescence ... quantitative determination of CK-MB, myoglobin ... acid (EDTA) whole blood and ... used as an aid in ...
... When your patients present with AMI ... essence, RAMP offers a rapid, reliable ... needs. Utilizing unique assay enhancement techniques, ... flow test cartridges, RAMP delivers highly ...
Medicine Products: