Navigation Links
Researchers report a complete description of gene expression in the human retina
Date:7/18/2013

BOSTON -- Investigators at Massachusetts Eye and Ear and Harvard Medical School have published the most thorough description of gene expression in the human retina reported to date. In a study published today in the journal BMC Genomics, Drs. Michael Farkas, Eric Pierce and colleagues in the Ocular Genomics Institute (OGI) at Mass. Eye and Ear reported a complete catalog of the genes expressed in the retina.

The retina is the neural tissue in the back of the eye that initiates vision. It is responsible to receiving light signals, converting them into neurologic signals and sending those signals to the brain so that we can see. If one thinks of the eye as a camera, the retina in the "film" in the camera. For these studies, the investigators used a technique called RNA sequencing (RNA-seq) to identify all of the messenger RNAs (mRNAs) produced in the human retina. The resulting catalog of expressed genes, or transcriptome, demonstrates that the majority of the 20,000+ genes in the human body are expressed in the retina. This in itself is not surprising, because the retina is a complex tissue comprised of 60 cell types.

In a more surprising result, Dr. Farkas and colleagues identified almost 30,000 novel exons and over 100 potential novel genes that had not been identified previously. Exons are the portions of the genome that are used to encode proteins or other genetic elements. The investigators validated almost 15,000 of these novel transcript features and found that more than 99 percent of them could be reproducibly detected. Several thousand of the novel exons appear to be used specifically in the retina. In total, the newly detected mRNA sequence increased the number of exons identified in the human genome by 3 percent.

"While this may not sound like a lot, it shows that there is more to discover about the human genome, and that each tissue may use distinct parts of the genome," said Dr. Pierce, Director of the OGI a
'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
617-573-4170
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... According to a study published today in PLOS ... world where malaria is common can mount an immune ... them to avoid repeated bouts of high fever and ... in their bloodstream. The findings may help researchers develop ... by the malaria parasite. , Each year, approximately 200 ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
(Date:4/17/2014)... Northwestern University synthetic biology team has created a ... programmable therapeutics that could travel the body and ... , Engineering cell-based, biological devices that monitor and ... clinical synthetic biology. However, no existing technology enabled ... patient,s physiological state and respond in a customized ...
(Date:4/17/2014)... many as 10 million older Americans suffer from depression, ... , However, new research a project that followed ... six years found that Internet use among the ... than 30 percent. , "That,s a very strong effect," ... telecommunication, information studies and media who led the project. ...
(Date:4/17/2014)... Calif., April 17, 2014 By discovering a new ... after a stroke, researchers at UC Irvine and the ... that may limit or prevent stroke-induced brain damage. , ... fourth-leading cause of death and primary reason for disability ... in a stroke and lets blood-borne material into the ...
Breaking Medicine News(10 mins):Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... , MORRISTOWN, N.J., July 27 ... ), a leader in generic and specialty branded pharmaceuticals, announced that ... Officer, has taken a leave of absence from the Company for ... Watson, announced that R. Todd Joyce, Vice President, Corporate Controller and ...
... , , NEW YORK, July ... company developing a minimally invasive drug delivery platform for the regional treatment of ... In addition, the Company reported its financial results for the second quarter ended ... , , Screened 40 Additional Patients ...
... , SWIFTWATER, Pa., July 27 Sanofi ... SNY ), announced today that it has shipped the ... Fluzone vaccine is indicated for active immunization in people 6 months ... subtypes A and type B contained in the seasonal influenza vaccine. ...
... , , ... California Cardiothoracic Surgery Center specializes in cardiothoracic surgery including ... seem like serious symptoms. In fact, most people brush off these ... symptoms can be indications of the need for mitral ...
... , , , , ... AMGN ) reported adjusted earnings per share (EPS) of $1.29 for the ... second quarter of 2008. Adjusted net income increased 6 percent to $1,311 million ... of 2008. , , Total revenue decreased 1 percent during the ...
... , , WASHINGTON, July ... Action, the legislative lobbying arm of Family Research Council, will ... President Obama,s proposed government takeover of the health care system. ... Congressional leaders to discuss the moral, ethical, and financial dangers ...
Cached Medicine News:Health News:Watson CFO Mark W. Durand to Take Leave of Absence 2Health News:Delcath Systems Provides Update on Progress 2Health News:Delcath Systems Provides Update on Progress 3Health News:Delcath Systems Provides Update on Progress 4Health News:Delcath Systems Provides Update on Progress 5Health News:Delcath Systems Provides Update on Progress 6Health News:Delcath Systems Provides Update on Progress 7Health News:Sanofi Pasteur Begins Shipments of Fluzone(R), Influenza Virus Vaccine for 2009-2010 Seasonal Influenza 2Health News:Sanofi Pasteur Begins Shipments of Fluzone(R), Influenza Virus Vaccine for 2009-2010 Seasonal Influenza 3Health News:Sanofi Pasteur Begins Shipments of Fluzone(R), Influenza Virus Vaccine for 2009-2010 Seasonal Influenza 4Health News:Sanofi Pasteur Begins Shipments of Fluzone(R), Influenza Virus Vaccine for 2009-2010 Seasonal Influenza 5Health News:Sanofi Pasteur Begins Shipments of Fluzone(R), Influenza Virus Vaccine for 2009-2010 Seasonal Influenza 6Health News:Southern California Surgical Center (heart411.com) Specializes in Mitral Valve Replacement 2Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 2Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 3Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 4Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 5Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 6Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 7Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 8Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 9Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 10Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 11Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 12Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 13Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 14Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 15Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 16Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 17Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 18Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 19Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 20Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 21Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 22Health News:Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29 23
(Date:1/15/2014)... plc (LSE: SHP, NASDAQ: SHPG ) announces that it ... the announced tender offer for all of the outstanding shares of ... the waiver, the transaction is no longer conditional on OFT approval, ... 2014 following the currently scheduled expiration time, subject to the satisfaction ...
(Date:1/15/2014)... 2014 Tegra Medical is very pleased to announce the ... new Chief Executive Officer.  Mark was promoted from his current ... the company,s four facilities in Massachusetts , ... joined Tegra Medical in 2012 with 20+ years of broad-based ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... TheraQuest Biosciences, Inc., a clinical stage pain management company today announced ... Vice President, Pharmaceutical Development and General Counsel and Douglas R. Baum ... 2010 , TheraQuest unveiled its analgesic product pipeline and provided a status ... , , ...
... 22 OvaGene Oncology Inc., a biotechnology company specializing in ... announced today the opening of its new clinical and research laboratory ... the central headquarters for operations, research, and molecular clinical lab testing. ... The ...
Cached Medicine Technology:Two Pharmaceutical Executives Join TheraQuest Management Team 2OvaGene Oncology Opens New Innovative Gynecologic Cancer Laboratory and Research Facility 2
... The Finnpipette Digital offers improved ergonomics ... rounded handle, modified grippy finger rest ... operator comfort and efficiency. Finnpipette Digitals ... power-boosted gearing mechanism (pat. pend.) and ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features: Eppendorf "pipette/tip" ...
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 100-1,000 microliter range....
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,409-7) or contact custom...
Medicine Products: