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Researchers reach consensus on use of deep brain stimulation to treat Parkinson's
Date:10/13/2010

d what information is available on DBS appears in academic journals, is focused and limited, and is usually written by one group reflecting their biases.

Bronstein, who directs the UCLA Movement Disorder Program and is a member of the UCLA Brain Research Institute, said the results of the group's meeting will help clarify some of the issues about DBS treatment. Among their findings:

  • The best candidates for DBS are those who can't tolerate the side effects of medications, who don't suffer from significant active cognitive or psychiatric problems, and who do suffer from tremors and/or motor fluctuations.
  • DBS surgery is best performed by an experienced team and neurosurgeon with expertise in stereotactic neurosurgery microsurgery deep within the brain that is based on a three-dimensional coordinate system using advanced neuroimaging.
  • DBS, when used in the two most commonly treated areas of the brain the subthalamic nuclei and the globus pallidus pars interna is effective in addressing the motor symptoms of Parkinson's, but treatment in the subthalamic nuclei may cause increased depression and other symptoms in some patients.
  • Surgical removal of the area of the brain causing Parkinson's disease is still an effective alternative and should be considered in patients.
  • Surgical complication rates vary widely, with infection being the most commonly reported complication of DBS.


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Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California -- Los Angeles
Source:Eurekalert

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