Navigation Links
Researchers reach consensus on use of deep brain stimulation to treat Parkinson's
Date:10/13/2010

Since the late 1990s, deep brain stimulation (DBS) has proven to be a lifeline for some patients suffering from Parkinson's disease, a cruel neurological disorder that can cause lack of control over movement, poor balance and coordination, and rigidity, among other symptoms.

The procedure is used only for patients whose symptoms cannot be adequately controlled with medications. A neurosurgeon uses magnetic resonance imaging or computed tomography to identify the exact target within the brain where abnormal electrical nerve signals generate the disease's tremors and other symptoms, and a neurostimulator is then surgically implanted to deliver electrical stimulation to that area to block the signals.

The goal, ultimately, is to improve the patient's quality of life.

Yet despite its effectiveness, there has been no consensus on several aspects of the use DBS, including which patients make the best candidates, where the optimal location for the placement of electrodes is, and the role that still exists for surgical removal of the damaged areas of the brain.

To address these concerns, a more than 50 DBS experts including world-renowned neurologists, clinicians and surgeons pooled their experience with the procedure and reached a consensus. The goal of this "meeting of the minds" was to better inform Parkinson's patients and their families about the potential of DBS treatment and to better inform the medical community in suggesting the procedure.

The results of their April 2009 meeting are presented in the current online edition of the journal Archives of Neurology.

"We know that very little accessible information is out there to help a Parkinson's patient make an informed decision as to whether he or she would be a good candidate for deep brain stimulation," said Jeff Bronstein, a UCLA professor of neurology and lead author of the report.

Surgical trials take a long time, he said, and what information is available on DBS appears in academic journals, is focused and limited, and is usually written by one group reflecting their biases.

Bronstein, who directs the UCLA Movement Disorder Program and is a member of the UCLA Brain Research Institute, said the results of the group's meeting will help clarify some of the issues about DBS treatment. Among their findings:

  • The best candidates for DBS are those who can't tolerate the side effects of medications, who don't suffer from significant active cognitive or psychiatric problems, and who do suffer from tremors and/or motor fluctuations.
  • DBS surgery is best performed by an experienced team and neurosurgeon with expertise in stereotactic neurosurgery microsurgery deep within the brain that is based on a three-dimensional coordinate system using advanced neuroimaging.
  • DBS, when used in the two most commonly treated areas of the brain the subthalamic nuclei and the globus pallidus pars interna is effective in addressing the motor symptoms of Parkinson's, but treatment in the subthalamic nuclei may cause increased depression and other symptoms in some patients.
  • Surgical removal of the area of the brain causing Parkinson's disease is still an effective alternative and should be considered in patients.
  • Surgical complication rates vary widely, with infection being the most commonly reported complication of DBS.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California -- Los Angeles
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... , ... In honor of National Physical Fitness and Sports Month in May, ... fitness journey on social media. , The foot care company, which specializes in ... voucher each week during May to one winner. , “Whether the goal is to ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Philip Shindler, dentist in ... day treatments. In the past, many necessary dental treatments could require multiple appointments to ... anesthetic shots and extra chair time. Not only could this be inconvenient, but it ...
(Date:5/2/2016)... ... , ... MedPro Waste Disposal, LLC (MedPro) is proud to announce that it ... back service for an all-inclusive rate. MedPro Disposal President, Dan Hansen, says, “We’re really ... of the clients in the country who are looking for an alternative to their ...
(Date:5/2/2016)... ... May 02, 2016 , ... Zitter ... Specialty Pharmacy Patient Satisfaction Award that will recognize specialty pharmacies for their achievements ... Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled throughout 2016. Results will ...
(Date:5/2/2016)... ... May 02, 2016 , ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed ... Manhattan College, made the cut. The WUGC is being held in London, England this year ... gold in the men’s division, another gold in the women’s masters division, and a silver ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016 Transparency Market ... Devices Market - Global Industry Analysis, Size, Share, Growth, ... report, the global skincare devices market was valued at ... expand at a CAGR of 10.1% from 2015 to ... Browse the full Skincare Devices Market (Treatment Device - ...
(Date:4/27/2016)... April 27, 2016 Tie-up with ... initiative to save newborns   Fortis ... & newborns in collaboration with Breast Milk Foundation (BMF), a ... Pasteurized Human Milk Bank, ,Amaara, in Delhi-NCR today. This non-profit ... source for infants and should be available to babies deprived ...
(Date:4/27/2016)... , April 27, 2016 Shire plc ... Jeff Poulton , Chief Financial Officer, will present at the ... Boston, MA on Wednesday, May 04, 2016, 10:00 ... will be available on the Presentations and Webcasts section of ... of the webcast will be available on this same website ...
Breaking Medicine Technology: