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Researchers publish molecular disease model for melanoma
Date:3/30/2011

ed therapy with potential efficacy for that subtype.

Commented Dr. Keith Flaherty, Director of Developmental Therapeutics at Massachusetts General Hospital and co-chief editor of Cancer Commons Melanoma: "While earlier stages of melanoma can be successfully treated by surgical excision, advanced stages are uniquely refractory to standard chemotherapy. Recent developments in our understanding of the molecular drivers of this disease have led to a new generation of targeted therapies that are proving effective in patients whose tumors harbor certain genetic defects. Rather than treating melanoma as a single disease, it makes sense to stratify tumors into molecular subtypes and treat each with the most appropriate therapies."

The molecular disease model for melanoma is the first of many such models planned by Cancer Commons, the open science initiative for personalized oncology that was initially convened by CollabRx. Cancer Commons is creating a network of rapid learning communities where physicians, scientists, and patients collaborate to provide each patient with the best possible outcome by personalizing therapy based on the tumor's genomic subtype. CollabRx is developing web-based applications and services that facilitate this collaboration; the first of these, The Targeted Therapy Finder Melanoma, leverages the MDMM to find treatments targeted to a patient's specific molecular profile.

"Cancer Commons puts the patient at the front end of a remarkable experiment in 'translational medicine' - one in which basic molecular biology, computational methods and a network of experts and institutions collaborate to work out personalized medical solutions," said Donald Kennedy, Ph.D., Editor-in-Chief, Science (2000-2008). "Our goal is to run this translational loop in real time, so that what is learned from one patient can be disseminated in time to help the next. By having researchers, clinicians and patients on the same platform, we can take y
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Contact: Jen Laloup
jlaloup@plos.org
415-624-1220
Public Library of Science
Source:Eurekalert

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