Navigation Links
Researchers propose a novel prognostic model for disease-specific survival in BCa patients
Date:3/18/2013

Milan, 18 March 2013 A new study from Japan investigated various prognostic indicators, including clinico-pathological and pre-operative hematological factors to develop a novel prognostic factors-based risk stratification model for disease-specific survival (DSS) in bladder cancer (BCa) patients treated with radical cystectomy (RC).

This large series demonstrated that two types of pre-operative haematological disorders assessed by haemoglobin (Hb) and C-reacted protein (CRP) are independent prognostic indicators for patients with BCa treated by RC.

"Despite the wealth of evidence on the oncological significance of various clinico-pathological and molecular parameters for survival in invasive BCa patients treated with radical cystectomy, alterations of pre-operative haematological parameters have not been sufficiently addressed," write the authors of the study.

"The findings suggest that pre-operative Hb and CRP levels, which can be easily obtained during routine practice, provide additional independent prognostic information for DSS. Moreover, our risk stratification model, which combines both hematological and pathological parameters, may provide physicians with useful prognostic information for identifying patients who may be candidates for multimodal treatment, including innovative adjuvant treatments."

In the course of the study, the researchers performed a retrospective analysis of 249 consecutive BCa patients treated with RC without neoadjuvant therapy at several institutions.

Prognostic value of the pre-operative hematological laboratory parameters along with patient's clinico-pathological parameters were evaluated by univariate and multivariate Cox proportional hazard model analyses. Based on these data, the scientists developed a new scoring model to predict DSS after RC using the regression coefficients of the multivariate model.

One-, 3-, and 5-year DSS rates were 89.1%, 69.3%, and 62.7%, respectively. In multivariate analysis, pre-operative values of low hemoglobin (Hb) (< 10g /dL) and high C-reacted protein (CRP) (> 0.5 mg / dL), pathological T stage (≥ pT3a), lympho-vascular invasion (LVI) and positive surgical margin (PSM) status were independent factors for predicting poor prognosis. The score was calculated as 2 (if PSM) + 2 (Hb < 10g /dL) + 1 (if ≥ pT3a) + 1 (if LVI) + 1 (CRP > 0.5 mg / dL) and 0 (if otherwise).

The 4-year DSS in patients with a score in the ranges 0-1 (low-risk), 2-3 (intermediate-risk) and 4-7 (high-risk) was 83.4%, 48.8% and 5.9%, respectively All differences in DSS between subgroups were P < 0.0001.


'/>"/>

Contact: i.moerkerken@uroweb.org
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. More parents say they wont vaccinate daughters against HPV, researchers find
2. Kessler Foundation researchers share findings in rehabilitation research at AAN meeting in San Diego
3. Mayo Clinic and Illinois researchers develop new sensor for methylated DNA
4. Researchers advance fight against biggest hidden virus
5. Brain researcher James Poulet receives the 2013 Paul Ehrlich Prize for Young Researchers
6. Bradley Hospital researchers find age-related changes in how autism affects the brain
7. LA BioMed physician-researchers honored as top doctors
8. IU researchers receive $3.2 million to develop, improve therapies for pancreatic cancer
9. Cancer researchers discover new type of retinoblastoma in babies
10. Researchers Turn from Drugs to Mini Organs for Diabetes Cure, According to Yasmin Malhotra
11. Researchers develop new tool to eliminate 30-day hospital readmissions in heart failure patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... 5,000 SF expansion and facility enhancement of their 503A compounding pharmacy located in ... the growing demand of physicians and patients throughout the United States for high-quality ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... for tech innovators, engineers, and scientists from around the world, announces the launch ... users a quick and easy portal to research breakthroughs and trending news, vital ...
(Date:1/19/2017)... ... January 19, 2017 , ... Cosmetic Town, an online plastic surgery ... order to make it easier for their readers to get the information they desire. ... as well as the techniques used on those particular areas. , “We are excited ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... dermatologist by the American Board of Dermatology and fellowship trained Mohs and cosmetic ... National Institutes of Health, Dr. Li completed his internship in internal medicine at ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... a doctor who administered fillers that resulted in severe facial disfiguration. After four ... taken on by doctors at UCLA Medical Center, who removed the substances in ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... -- Research and Markets has announced the addition ... Types, OTC Amplifiers, Diagnostic Instruments), Sales Volume, Company Analysis and ... ... Market Sales Volume, Company Analysis and Forecast to 2022 provides ... The growing prevalence of hearing impairment coupled with ...
(Date:1/20/2017)... BUFFALO, N.Y. , Jan. 20, 2017 /PRNewswire/ ... health programs, has announced the launch of an ... to new guidelines on opioids and helps stem ... Opioids are often prescribed to treat chronic non-cancer ... disease) despite serious risks and lack of evidence ...
(Date:1/19/2017)... , Jan. 19, 2017 ... Summary GlobalData,s new report, "Germany Cataract Surgery Devices ... the Germany Cataract Surgery Devices market. The report provides ... and average prices (USD) within market segements - Phacoemulsification ... also provides company shares and distribution shares data for ...
Breaking Medicine Technology: