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Researchers present findings on promising biomarker for esophageal cancer
Date:5/5/2014

n effectively detect these changes in the DNA.

The study is funded through the Barrett's Esophagus Translational Research Network (BETRNet), a $5.4 million grant to Case Western Reserve University School of Medicine. The five-year award supports a research team, led by Dr. Chak, collaborating to develop an understanding of the basis of Barrett's esophagus and its conversion to esophageal carcinoma through genetic, molecular and physiologic studies.

The study is collaborative with the National Cancer Institute's Specialized Program of Research Excellence (SPORE) in Gastrointestinal (GI) Cancers award to the School of Medicine. The $11.3 million SPORE grant, led by Sanford Markowitz, MD, focuses on translational research aimed at reducing the incidence and deaths from colon and esophageal cancers. The study is additionally supported by the NCI's Early Detection Research Network (EDRN) program that is also led by Dr. Markowitz, and is supported by a $1.5 million NCI grant to Case Western Reserve.

"Our team's hope is that the use of molecular markers for non-endoscopic screening will drive down the cost and increase the ease of screening for these early esophageal lesions that can give rise to cancer," said Dr. Markowitz, an oncologist at UH Case Medical Center Seidman Cancer Center and Ingalls Professor of Cancer Genetics at Case Western Reserve School of Medicine. "Longer term we hope to find additional markers that will allow the same approach to be used in the monitoring of Barrett's patients to detect early progression to more advanced disease."

Senior faculty collaborators on the research team included Dr. Chak, Dr. Markowitz and Joseph Willis, MD, Vice-Chair of the Department of Pathology at UH and the School of Medicine. First author on the report is Helena Moinova, PhD, instructor in the Department of Medicine at the School of Medicine, who was also assisted by James Lutterbaugh and Apoorva Chandar.

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Contact: Alicia Reale
alicia.reale@uhhospitals.org
University Hospitals Case Medical Center
Source:Eurekalert

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