Navigation Links
Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
Date:7/1/2013

HOUSTON Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys.

Findings from research conducted at Beth Israel Deaconess Medical Center, Harvard Medical School and Massachusetts Institute of Technology in Boston and continued at The University of Texas MD Anderson Cancer Center are reported in an advance online publication at Nature Medicine on June 30.

"Answering a fundamental question about the origin of these cells by identifying four separate pathways involved in their formation allows us to look at ways to block those pathways to treat fibrosis," said senior author Raghu Kalluri, Ph.D., M.D., MD Anderson chair and professor of Cancer Biology. "It's highly unlikely that a single drug will work."

"In addition to being lethal in its own right, fibrosis is a precursor for the development of cancer and plays a role in progression, metastasis and treatment resistance," Kalluri said. "In some cancers, such as pancreatic cancer, up to 95 percent of tumors consist of fibrotic stroma."

Working in genetic mouse models of kidney fibrosis, Kalluri and colleagues identified four sources of cells called myofibroblasts, the dominant producers of collagen. Collagen normally connects damaged tissue and serves as scaffolding for wound-healing. As healing occurs, myofibroblasts and collagen usually diminish or disappear.

In fibrosis, collagen production marches on. While inflammation-inhibiting drugs can sometimes slow its progress, fibrosis now is treatable only by organ transplant.

Myofibroblasts have four types of parents

The researchers employed a fate-mapping strategy to track cells on their way to becoming myofibroblasts. In fate mapping, the promoter of a protein expresses a color inside a cell that remains with the cell no matter wh
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers use immunocytochemistry to determine ALK status
2. Researchers find 2 new methods to determine ALK status
3. CWRU researchers trace inner-city womens health issues to childhood traumas
4. Penn Medicine researchers discover link between fear and sound perception
5. UCI researchers awarded $2.27 million to create novel diabetes treatments
6. MS researchers determine that brain reserve independently protects against cognitive decline in MS
7. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
8. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
9. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
10. Researchers identify master coordinator for aortic rupture
11. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/5/2015)... ... 05, 2015 , ... Women’s Excellence in Wellness, powered by Movestrong ... The special consists of 2 months of unlimited classes for just $65. Student ID ... at 1410 South Lapeer Road in Lake Orion. , Women’s Excellence ...
(Date:7/4/2015)... , ... July 04, 2015 , ... Chronic Neck Pain. ... chronic pain sufferers have pain located in the neck. Another 19% suffer from head, ... Chiropractic literature suggests that 45% of American workers must deal with neck ...
(Date:7/3/2015)... (PRWEB) , ... July 03, 2015 , ... ... for enrollment on July 2nd creating a buzz of media attention. In an ... published online by HonestyFirstReviews.com's Tiffany Hendricks. , "These days many people are feeling ...
(Date:7/3/2015)... ... July 03, 2015 , ... Renowned rhinoplasty surgeon ... the 2016 Dallas Rhinoplasty Symposium . To be held from March 4th - ... be held at the Westin Galleria Dallas. , Designed to take participants from the ...
(Date:7/3/2015)... ... July 03, 2015 , ... Smoothies are all the rage right ... and easily accessible, quality ingredients. Aurora Natural is proud to introduce a new line ... of fiber, protein, antioxidants, vitamins and minerals! , Aurora is offering a variety of ...
Breaking Medicine News(10 mins):Health News:New Advancement in Treatment of Chronic Neck Pain 2Health News:New Advancement in Treatment of Chronic Neck Pain 3Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 2Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 3Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Aurora Product, Inc. Announces An Original New Line: Smoothie Fixins’ 2
... day of family skiing in Canada ended with actress Natasha Richardson hospitalized ... be the exception and not the rule, the American Academy of Orthopaedic ... while on the slopes., , ... surfaces those frigid temperatures can produce on the ski slopes , ...
... Award Dinner to Benefit Phoenix HouseThe Plaza, New York, March 30, ... the Grammy Award-winning musician, producer, and humanitarian, will join Fireman ... Paul Fireman , Dan Fireman, Shaquille O,Neal, Eli Manning , ... other stars from music, sports, and business to honor Lisa ...
... New Survey Suggests Parents Most Influence Teens, Decisions About SexWASHINGTON, ... States increased 1% in 2007, according to data released today ... is the second year in a row that the teen ... of continuous decline in the teen birth rate. That ...
... Finding could lead to new treatments for the disease, researchers ... genes that support replication of the hepatitis C virus (HCV) ... Hospital researchers. , They also found that blocking several ... may be a few years away from developing therapies based ...
... eyelid surgery were ranked the top 3 cosmetic surgery procedures in 2008 ... Plastic Surgery. The clinical results of New Jersey plastic surgeon , ... , ... Paramus, NJ (Vocus) March 19, 2009 -- Dr. Paul Parker, a ...
... School of Medicine has received a four-year, $4.7 million ... new ways to stop deadly hospital-acquired infections that often ... share of the national 2008-2009 tobacco settlement, will focus ... and the drug-resistant bacteria known as MRSA, which cause ...
Cached Medicine News:Health News:Media Alert: Tips on Skiing Safely From the American Academy of Orthopaedic Surgeons 2Health News:Wyclef Jean and Miri Ben-Ari to Lead Phoenix House Tribute to Lisa Ellis of Fireman Capital Partners and Carnival House Recordings 2Health News:Wyclef Jean and Miri Ben-Ari to Lead Phoenix House Tribute to Lisa Ellis of Fireman Capital Partners and Carnival House Recordings 3Health News:Teen Birth Rate Up For Second Year in a Row 2Health News:Progress Reported Against Gene Involved in Hepatitis C 2Health News:New Jersey Plastic Surgeon Helps Determine Top Cosmetic Surgery Procedures of 2008 2Health News:New Jersey Plastic Surgeon Helps Determine Top Cosmetic Surgery Procedures of 2008 3Health News:Pitt receives $4.7 million award to reduce hospital-acquired infections 2
(Date:7/3/2015)... India , July 4, 2015 ... continue cible les épidémies que sont l,hypertension, le ... et du Sud-Est, par l,intermédiaire de plateformes éducatives ... maladies.      (Photo: http://photos.prnewswire.com/prnh/20150630/227090 ... en charge le diabète en ligne , ...
(Date:7/3/2015)... 3, 2015 Der ... bestimmter Abschlussbedingungen eine 100-prozentige Beteiligung am Unternehmen ... Mit dieser Übernahme dringt Lupin in den ... von 765 Mrd. RUB im Jahr 2014 ... gehörte (IMS Health). Seit über einem Jahrzehnt ...
(Date:7/2/2015)... HILL, N.C. , July 2, 2015 /PRNewswire/ ... own employees to capture critical product and market ... are many benefits to employee-based studies, it is ... leverage their own internal employees to capture critical ... study by benchmarking firm, Best Practices, LLC, most ...
Breaking Medicine Technology:Lutter contre trois maladies chroniques majeures en Asie centrale et du Sud-Est grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Asie centrale et du Sud-Est grâce à la formation médicale 3Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3Leveraging Employee Insights to Produce Cutting-Edge Market Research 2
... Sept. 26 Isis,Pharmaceuticals, Inc. (Nasdaq: ISIS ... Biosciences, Inc. (Ibis), has been awarded a subcontract,of ... aid in influenza,surveillance research through application of the ... jointly by Ibis and the Lovelace,Respiratory Research Institute ...
... Visiting Nurse Associations of America, Families Fighting Flu and The, Clorox ... ... Less Scary, WASHINGTON, Sept. 25 A new report by the,Centers ... children who need to get a flu vaccination actually get,one, despite the ...
Cached Medicine Technology:Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies 2Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies 3Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies 4Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies 5Influenza is Leading Cause of Vaccine-Preventable Deaths for Kids; Despite CDC Recommendations, Moms Still Don't Vaccinate 2Influenza is Leading Cause of Vaccine-Preventable Deaths for Kids; Despite CDC Recommendations, Moms Still Don't Vaccinate 3Influenza is Leading Cause of Vaccine-Preventable Deaths for Kids; Despite CDC Recommendations, Moms Still Don't Vaccinate 4Influenza is Leading Cause of Vaccine-Preventable Deaths for Kids; Despite CDC Recommendations, Moms Still Don't Vaccinate 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: