Navigation Links
Researchers open door to new HIV therapy
Date:1/28/2014

rries attached CD4 receptors to the lysosome for destruction.

"The new high-resolution image reveals a cavity at the site where Nef binds to AP2, that could be a good site for drug targeting," Bonifacino said.

"This cavity on AP2 is not known to be used by any other host protein, so if we interfere with the cavity we are not going to interfere with any host cell function, only the function of Nef," he said. "This will inform better searches for inhibitors."

Hurley cautioned, however, that the research "needs more validation to prove that the cavity is a target. But we are excited because it is a potential target, and these things don't come along every day."

Taking a snapshot

UC Berkeley scientist Xuefeng "Snow" Ren obtained the high-resolution snapshot of Nef bound to AP2 by crystallizing the proteins and zapping the complex with X-rays. She calculated the 3-D structure from the resulting X-ray diffraction pattern. She is now at work crystallizing the Nef-AP2 complex bound to the CD4 receptor to look for other possible drug targets on AP2 or CD4 that could prevent Nef from trashing CD4.

Hurley and Bonifacino are primarily interested in the function of adaptors like AP2 there are at least five known adaptors in human cells that control intracellular membrane traffic.

"This work was an extension of our work on clathrin adaptors, an opportunity to do something relevant to fighting HIV that was based on the purely basic research we are doing on the sorting of proteins to lysosomes," Hurley said.


'/>"/>

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers find changes to protein SirT1
2. Researchers use sensory integration model to understand unconscious priming
3. CWRU researchers find epileptic activity spreads in new way
4. IU School of Medicine researchers awarded $300,000 GE/NFL grant to study concussions
5. UGA researchers discover origin of unusual glands in the body
6. Air Force awards over $1 million to UC trauma researchers
7. UCLA researchers develop risk calculator to predict survival in heart failure patients
8. Mount Sinai researchers find promising new drug targets for cocaine addiction
9. Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
10. Researchers awarded grant from the DeGregorio Family Foundation
11. Penn researchers run successful HIV intervention project in S. Africa
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers open door to new HIV therapy
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 ... biology, today announced Dr. Xun Wang ... all Research & Development. , Triton has developed a ... value algae-based proteins. According to Dr. Wang, the platform ... traditional expression systems. He says, “Algae are unique because ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 The global ... CAGR of 7.6%, to reach $50.4 billion by 2018 ... healthcare systems industry, and pharmaceutical industry are driving the ... model to enhance their focus on core business, reduce ... and trained staff (further reducing hiring and training costs), ...
(Date:10/25/2014)... Background: , In 1998 Bob Savage founded the Connecticut ... the field of establishing recovery community organizations. Bob had ... he retired, he set out to answer a couple questions ... , 1. Where are the people in recovery when ... Can the recovery community be organized to advocate for issues ...
(Date:10/25/2014)... 2014 Market Research Report ... 2009-2019 is a professional and in-depth market ... industry. The report firstly reviews the basic ... application and manufacturing technology. The report then ... Molecular Diagnostics listing their product specification, capacity, ...
(Date:10/25/2014)... York (PRWEB) October 25, 2014 ... lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed against Boston ... in U.S. District Court, Southern District of West ... Judgment on Punitive Damages in a group of ... a ruling issued on October 21st, U.S. District ...
Breaking Medicine News(10 mins):Health News:Triton Algae Innovations Ltd. Names Dr. Xun Wang as President 2Health News:Triton Algae Innovations Ltd. Names Dr. Xun Wang as President 3Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 2Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 3Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 4Health News:CCAR Accepting Nominations for the Bob Savage Recovery Advocate of the Year Award 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 3Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 4Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4
... Resources, an,association management and consulting firm for non-profit organizations,located ... launch of an,innovative e-learning solution to be used by ... of the service will offer a way to,increase revenue ... , "We,re excited about this ...
... CORTLANDT MANOR, N.Y., Feb. 3 Polymedco is pleased to ... and screening. It is designed to educate both patients ... cancer. The website is located at www.fobt-tests.com . ... cancer related death today in the United States. However, ...
... of change echoing across the country, Americans have been ... greatness of this nation. America,s ability to seize this ... by each individual. In celebration of the inherent excellence ... forum in which everyday stories of greatness will be ...
... Aldridge LLP (MLA) is pleased to announce that Paul ... has joined the firm in our Government Contracts Department. ... firm,s Life Sciences and Public Health Preparedness practice in ... addition to helping clients develop strategies for offering their ...
... Mich., Feb. 3 Cherries are not only good for ... According to recent,data, more than 9 out of 10 Americans ... say they,re purchasing "locally produced" products,and the majority are defining ... About ninety-five percent of cherries consumed in ...
... 3 To mark American Heart,Month, deCODE genetics (Nasdaq: ... of,February it will offer its deCODEme Cardio Scan(TM), the ... inherited risk of heart,attack, stroke and atrial fibrillation, intracranial ... promotional price of,$100. , On ...
Cached Medicine News:Health News:Center for Association Resources Launches E-Learning Service 2Health News:Nature Made(R) Seeking Stories of Individual Greatness for Upcoming Documentary 2Health News:Nature Made(R) Seeking Stories of Individual Greatness for Upcoming Documentary 3Health News:Former Assistant Secretary of Defense for Homeland Defense Joins McKenna Long & Aldridge LLP 2Health News:Cherries: 'America's Super Fruit' Offers Homegrown Health Benefits 2Health News:Cherries: 'America's Super Fruit' Offers Homegrown Health Benefits 3Health News:deCODEme(TM) Takes on Heart Disease in February 2Health News:deCODEme(TM) Takes on Heart Disease in February 3Health News:deCODEme(TM) Takes on Heart Disease in February 4Health News:deCODEme(TM) Takes on Heart Disease in February 5
(Date:10/25/2014)...  In 2008, two of Dr. Gurney,s employees reported ... substances, on a regular basis, that were not used ... was practicing "all the time" while under the influence. ... said that Dr. Gurney was prone to "making mistakes ... Dr. Gurney,s behavior became increasingly erratic and unfocused, and ...
(Date:10/25/2014)... , Oct. 24, 2014 In conjunction ... quarter 2014 financial results press release, you are invited ... broadcast live over the internet on Monday, November 3, ... Time). A live audio webcast of the ... http://www.durect.com and clicking "Investor Relations."  If you ...
(Date:10/25/2014)... , Oct. 24, 2014 Burzynski Research Institute, ... Drug Administration (FDA) has given the company permission to ... in patients > 3 months of age with a ... placed in one of five treatment groups based on ... prior treatment for DIPG. The primary study endpoint is ...
Breaking Medicine Technology:Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 2Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 3DURECT Corporation Invites You to Join its Third Quarter 2014 Earnings Conference Call 2Burzynski Research Institute, Inc. Announces FDA Permission to Launch a New Clinical Trial in Diffuse Intrinsic Brainstem Glioma 2
... is precision, ergonomics, and value!, Comfortable ... non-slip, contoured handle , Finer control while ... , Stress-free tip ejection with long, lever ... decontamination and sterilization without the need for ...
... Finnpipette Focus multichannel ... dispensing of reagents into ... for 0.1-10 l volumes. ... of Finnpipette Focus multichannels, ...
... The Finnpipette Digital Multichannel, ... even lighter work of routine ... all these advanced features: Soft-touch ... micro volume pipetting (0.5-10ul models), ...
... rows, and microplatesthat is the area of ... becoming an ever-increasing force. Ergonomics (reduced weight ... reason that the Multichannel Research model was ... provides effective, precise, and rapid processing of ...
Medicine Products: