Navigation Links
Researchers open door to new HIV therapy
Date:1/28/2014

he body," he said.

HIV hijacks cellular machinery

HIV contains a small number of genes that produce only 15 different proteins, all of which hijack some aspect of immune cells' internal machinery to produce more copies of the virus.

Current anti-AIDS drugs block three HIV enzymes proteins that transcribe and insert the virus' genetic material, and snip some of the encoded proteins but researchers are now looking for drugs that target the other proteins as backups to current therapies. In particular, they are searching for ways to block sites on host proteins to which the virus proteins bind in order to stop HIV. This has to be done without interfering with normal cell function, however.

Nearly 20 years ago, scientists showed that without the protein Nef short for negative factor HIV is far less infective. Some patients can live for decades without problems if infected with a Nef-defective virus.

Since then, more details have emerged about Nef's role. HIV enters immune system cells via a receptor called CD4, but once "HIV gets into cells through the CD4 door, it slams the door shut behind itself to prevent unproductive re-infection," Hurley said.

Scientists aren't sure why HIV slams the door on other viruses, he said, though it may be a way to prevent too many viruses entering the same cell, making the cellular environment less favorable for productive viral replication.

Whatever the reason, the virus prevents further HIV infection by ridding the cell surface of all other CD4 receptors. Nef achieves this by tagging the CD4 receptor so that the cell thinks it is trash and carries it to the cell's incinerator, the lysosome, where it is destroyed. Six years ago, Bonifacino and colleagues found that Nef does this by directly binding to a host protein, AP2, that latches onto a protein called clathrin. This causes the cell membrane to bulge inward and pinch off to form a small membrane bubble that ca
'/>"/>

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers find changes to protein SirT1
2. Researchers use sensory integration model to understand unconscious priming
3. CWRU researchers find epileptic activity spreads in new way
4. IU School of Medicine researchers awarded $300,000 GE/NFL grant to study concussions
5. UGA researchers discover origin of unusual glands in the body
6. Air Force awards over $1 million to UC trauma researchers
7. UCLA researchers develop risk calculator to predict survival in heart failure patients
8. Mount Sinai researchers find promising new drug targets for cocaine addiction
9. Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
10. Researchers awarded grant from the DeGregorio Family Foundation
11. Penn researchers run successful HIV intervention project in S. Africa
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers open door to new HIV therapy
(Date:10/22/2014)... 22, 2014 Shriners Hospitals for Children® ... change the current location of Shriners Hospitals for Children ... across from the University of Kentucky Albert B. Chandler ... care center, owned and operated by Shriners Hospitals for ... of children and their families well into the future. ...
(Date:10/22/2014)... 22, 2014 During the Western United ... supply runs dangerously low, Southern Oregon’s water is proving ... despite the lowest mountain snow pack on record in ... and early autumn.* That was the observation of journalist-hikers ... book “Hiking Southern Oregon,” during an interview with water ...
(Date:10/22/2014)... only 24 hours in a day, that doesn’t seem to be ... their busy schedules for exercise and fitness. Fortunately, one does not ... shape. Here are five ways you can reach your fitness and ... Commute , Consider riding a bike or taking the bus or ... If you must use your car to get to work, start ...
(Date:10/22/2014)... Steven Reinberg HealthDay ... Infants who quickly add weight and length may be showing ... suggests. In adults, certain genes have been linked to ... proportionate gains in fat and lean muscle, the researchers said. ... heavier and taller. By ages 2 and 3, however, these ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... of conventional in vitro fertilization (IVF) -- the incubation of ... in a device inside the vagina, new research suggests. ... device, called an INVOcell, might sharply cut costs for pricey ... technology more accessible to those who don,t live near big-city ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4
... Kendle (Nasdaq: KNDL ) a,leading, global full-service ... full year 2008. , (Logo: ... The Company now expects full year 2008 net ... to $480 million, down from the previous range of ...
... Twenty-two location cardiovascular group practice to use Sage ... and position itself for pay-for-performanceTAMPA, Fla., Jan. 12 ... Institute, a Saginaw-Mich.-based group practice including 33 nationally ... selected the integrated Sage Intergy practice management (PM) ...
... Assurance Determines Health Services are GoodVIRGINIA BEACH, Va., ... AGP ) today announced that its wholly ... been awarded New Health Plan Accreditation by the ... it offers high-quality health services to its 56,000 ...
... -- Mindray Medical,International Limited (NYSE: MR ... devices worldwide, today announced selected preliminary,unaudited results for ... The,preliminary results reported below include the results of ... ("DPM") starting from May,1, 2008. , ...
... Share Latest Breast Cancer Information at the Only International Conference ... An expected 800 young breast cancer survivors, caregivers and medical ... on breast cancer in pre-menopausal women from some of the ... Conference for Young Women Affected by Breast Cance r ...
... Align Technology,Inc. (Nasdaq: ALGN ) today ... cleared new labeling for the Invisalign system, thereby removing ... In addition,certain conditions previously listed as contraindications will now ... the years, our customers have demonstrated that many different ...
Cached Medicine News:Health News:Kendle Revises Full Year 2008 Guidance 2Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 2Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 3Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 4Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 5Health News:AMERIGROUP Community Care of Ohio Awarded New Health Plan Accreditation From NCQA 2Health News:Mindray Announces Preliminary 2008 Operating Results 2Health News:Mindray Announces Preliminary 2008 Operating Results 3Health News:Mindray Announces Preliminary 2008 Operating Results 4Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 2Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 3Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 4Health News:FDA Clears Expanded Labeling for the Invisalign System 2
(Date:10/22/2014)... YORK , Oct. 22, 2014 Sanomedics ... August 2014 report by Global Research & Data Services, ... per year from 2014 through 2018, as demand for ... States is the world,s largest market for ... with advanced thermometers is Sanomedics International Holdings, Inc. ...
(Date:10/22/2014)... REDWOOD CITY, Calif. , Oct. 22, 2014 ... ) today announced that results from the  IAP310 ... and Pain Medicine (RAPM), a peer-reviewed journal ... placebo-controlled, Phase 3 trial evaluating the safety and ... sufentanil sublingual tablet system (SSTS), for the treatment ...
(Date:10/20/2014)... , Oct. 20, 2014  PneumRx, Inc. ( ... pulmonology, today announced completion of enrollment in their RENEW ... Clinical Study is the FDA-approved IDE pivotal trial for ... emphysema. It was anticipated that the study, ... 2013, would take until the end of 2014 to ...
Breaking Medicine Technology:Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2PneumRx Completes RENEW Pivotal Trial Enrollment 2PneumRx Completes RENEW Pivotal Trial Enrollment 3
... SuperGen Inc.,(Nasdaq: SUPG ), a pharmaceutical company ... therapies for solid tumors and,hematological malignancies, today announced ... poster presentations at the AACR Annual Meeting,which will ... An oral presentation by Dr. Steven Warner ...
... A biosimilar product for,treating the negative effects ... cells of patients is safe and exhibits an ... This is the result of a clinical phase ... Pharma GmbH and the Indian manufacturer,INTAS Biopharmaceuticals Ltd. ...
Cached Medicine Technology:SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting 2SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting 3Neutropenia: Biosimilar Product from India Moves One Step Closer to European Market 2Neutropenia: Biosimilar Product from India Moves One Step Closer to European Market 3
... The Sphincter of Oddi ... (PNET) works with the Polygraf™ ... and analyze pressure signals from ... The PNET software and Polygraf ...
... VoiceControl is a unique tool ... voice commands to activate shortcut ... eliminating the need to perform ... you can devote your full ...
... Analysis for POLYGRAM NET™ works with the ... analyze multichannel EGG signals. The EGG analysis ... by performing an automatic electrode impedance check ... beginning of a recording. If the electrode ...
... POLYGRAM NET™ (PNET) works with the ... analyze pressure and EMG signals from ... graphic format. The PNET software and ... or water-perfused manometry catheters as well ...
Medicine Products: