Navigation Links
Researchers observe disruptions of daily rhythms in Alzheimer's patients' brains

Twenty-four hour cycles, known as circadian rhythms, are important for proper body functions, including for normal brain function and mental health. Disruptions of circadian rhythms and sleep-wake cycles have been observed in patients with Alzheimer's disease. A new study by Douglas Institute researchers unravels a possible basis for these perturbations.

First study to show function of clock genes in multiple areas of the human brain Until now, the genes contributing to this timing, known as clock genes, have only been found to be active in areas outside the brain, such as the skin and blood cells. Recent findings from the Douglas Mental Health University Institute are the first to show that these genes function in multiple areas of the human brain as well, as was shown previously in animals. These findings, published in this month's issue of the Journal of Biological Rhythms, have implications for the numerous individuals with sleep disturbances including those with Alzheimer's disease.

"To our knowledge, this is the first demonstration of circadian clock genes rhythmic expression in the human forebrain, or the front part of the brain," says senior author Nicolas Cermakian, a Douglas researcher and Director of the Laboratory of Molecular Chronobiology. "In addition, we showed that these rhythms are disrupted in the brains of Alzheimer's patients."

Shape of certain rhythms and the synchronization between brain areas were altered in Alzheimer's patients Dr. Cermakian and his colleagues looked for the presence of the circadian clock genes, PER1, PER2, and BMAL1 in the brain tissue of 58 donors; 27 were Alzheimer patients and 31 were controls. (Brain tissue was obtained from the Brain Bank of the Douglas.) All these clock genes were detected in three brain areas in both control and Alzheimer patients. In addition, there was a significant diurnal (day/night) expression of these genes in all three structures of control samples. In samples from Alzheimer's patients, the shape of these rhythms and the synchronization between brain areas were altered.

"The abnormal clock gene coordination that we observed in the tissues of Alzheimer's patients, might explain the sleep-wake deficits that are observed in this population," says Douglas Centre for Study and Treatment of Circadian Rhythms Director, Diane B. Boivin. "The altered sleep pattern worsens with disease progression and is the most frequent reason for institutionalization. Improved understanding of the process that underlies sleep-wake disruption may lead to better treatments or therapies. "Our ultimate goal is to improve the physical and mental health of individuals by providing scientifically grounded information."


Contact: Marie-france Coutu
514-761-6131 x2769
Douglas Mental Health University Institute

Related medicine news :

1. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
2. Researchers report widespread use of medications among pregnant women
3. Couch-Potato Kids: It Shows in Their Eyes, Researchers Say
4. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
5. Women Taking Calcium Supplements May Risk Heart Health, Researchers Say
6. Limiting carbs, not calories, reduces liver fat faster, UT Southwestern researchers find
7. Mutated gene found in dog disease the same in humans, MU researchers find
8. Researchers inject nanofiber spheres carrying cells into wounds to grow tissue
9. Wistar researchers follow a path to a potential therapy for NF2, a rare tumor disorder
10. Whales Not Just Singing the Same Old Song, Researchers Say
11. Boston University researchers find most substance-dependent individuals report poor oral health
Post Your Comments:
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... ... exchange technology and teleradiology services, has added Chris Hafey and Claude Hooton to ... at the Radiological Society of North America (RSNA) 2015 Annual Meeting and continues ...
(Date:11/28/2015)... CA (PRWEB) , ... November 28, 2015 , ... Pixel ... fully customizable media panels to choose from, the possibilities are endless. Users have full ... more. With the ProPanel: Pulse masking effects, users are sure to get heads to ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... the way that they are handling security in light of the recent terrorist attacks ... in an attempt to stop an attack from reaching U.S. soil. Especially around special ...
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... how filthy the toilets were," said an inventor from Hillside, N.J. "Many people ... improved seat cover so that individuals will always be protected from germs." , ...
(Date:11/27/2015)... LOS ANGELES, CA (PRWEB) , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only ... age of 30 (see Table 1-1 ). More than 3.7 billion people under ... simplex virus type 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 27, 2015 Research and Markets ( ... Intrauterine Devices Market 2015-2019" report to their offering. ... In this report, the author the present scenario and ... 2015-2019. To calculate the market size, the report considers ... products: Hormonal IUDs and copper IUDs. The report forecasts ...
(Date:11/26/2015)... India , November 27, ... --> --> ... personal emergency response system (PERS) ... steadily for 5 years with ... region expected to see a ...
(Date:11/26/2015)... North Carolina , 26 november 2015 ... Inc. (AAIPharma/CML) kondigt de geplande investering aan ... uitbreiding van de laboratoria en het mondiale ... . De uitbreiding zal resulteren in extra ... wordt voldaan aan de groeiende behoeften van ...
Breaking Medicine Technology: