Navigation Links
Researchers observe disruptions of daily rhythms in Alzheimer's patients' brains
Date:4/27/2011

Twenty-four hour cycles, known as circadian rhythms, are important for proper body functions, including for normal brain function and mental health. Disruptions of circadian rhythms and sleep-wake cycles have been observed in patients with Alzheimer's disease. A new study by Douglas Institute researchers unravels a possible basis for these perturbations.

First study to show function of clock genes in multiple areas of the human brain Until now, the genes contributing to this timing, known as clock genes, have only been found to be active in areas outside the brain, such as the skin and blood cells. Recent findings from the Douglas Mental Health University Institute are the first to show that these genes function in multiple areas of the human brain as well, as was shown previously in animals. These findings, published in this month's issue of the Journal of Biological Rhythms, have implications for the numerous individuals with sleep disturbances including those with Alzheimer's disease.

"To our knowledge, this is the first demonstration of circadian clock genes rhythmic expression in the human forebrain, or the front part of the brain," says senior author Nicolas Cermakian, a Douglas researcher and Director of the Laboratory of Molecular Chronobiology. "In addition, we showed that these rhythms are disrupted in the brains of Alzheimer's patients."

Shape of certain rhythms and the synchronization between brain areas were altered in Alzheimer's patients Dr. Cermakian and his colleagues looked for the presence of the circadian clock genes, PER1, PER2, and BMAL1 in the brain tissue of 58 donors; 27 were Alzheimer patients and 31 were controls. (Brain tissue was obtained from the Brain Bank of the Douglas.) All these clock genes were detected in three brain areas in both control and Alzheimer patients. In addition, there was a significant diurnal (day/night) expression of these genes in all three structures of control samples. In samples from Alzheimer's patients, the shape of these rhythms and the synchronization between brain areas were altered.

"The abnormal clock gene coordination that we observed in the tissues of Alzheimer's patients, might explain the sleep-wake deficits that are observed in this population," says Douglas Centre for Study and Treatment of Circadian Rhythms Director, Diane B. Boivin. "The altered sleep pattern worsens with disease progression and is the most frequent reason for institutionalization. Improved understanding of the process that underlies sleep-wake disruption may lead to better treatments or therapies. "Our ultimate goal is to improve the physical and mental health of individuals by providing scientifically grounded information."


'/>"/>

Contact: Marie-france Coutu
marie-france.coutu@douglas.mcgill.ca
514-761-6131 x2769
Douglas Mental Health University Institute
Source:Eurekalert

Related medicine news :

1. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
2. Researchers report widespread use of medications among pregnant women
3. Couch-Potato Kids: It Shows in Their Eyes, Researchers Say
4. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
5. Women Taking Calcium Supplements May Risk Heart Health, Researchers Say
6. Limiting carbs, not calories, reduces liver fat faster, UT Southwestern researchers find
7. Mutated gene found in dog disease the same in humans, MU researchers find
8. Researchers inject nanofiber spheres carrying cells into wounds to grow tissue
9. Wistar researchers follow a path to a potential therapy for NF2, a rare tumor disorder
10. Whales Not Just Singing the Same Old Song, Researchers Say
11. Boston University researchers find most substance-dependent individuals report poor oral health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... throughout Arkansas that offers insurance and financial preparation services, is providing an update ... City Rescue organization. , Rock City Rescue is a locally recognized nonprofit that ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
Breaking Medicine Technology: