Navigation Links
Researchers' new method may sharpen microscopic images
Date:3/21/2013

UT Dallas researchers are developing a new low-light imaging method that could improve a number of scientific applications, including the microscopic imaging of single molecules in cancer research.

Electrical engineering professor Dr. Raimund Ober and his team recently published their findings in the journal Nature Methods. In the journal, they describe a method which minimizes the deterioration of images that can occur with conventional imaging approaches.

"Any image you take of an object is translated by the camera into pixels with added electronic noise," Ober said. "Any distortion of an image makes it harder to obtain accurate estimates of the quantities you're interested in."

This method could greatly enhance the accuracy with which quantities of interest, such as the location, size, and orientation of an object, are extracted from the acquired images.

Ober and his team tackled this problem by using the EMCCD camera (a standard low-light image detector) in a highly unconventional setting. Using this method, scientists can estimate quantities of interest from the image data with substantially higher accuracy than those made with conventional low-light imaging.

"We have figured out through rigorous theoretical developments that when you run an EMCCD camera in such a way that very few photons hit each of its pixels, the resulting image is minimally corrupted by the camera noise," he said. "Our method is about using the EMCCD camera to its fullest potential, beyond what is commonly believed to be possible by the scientific imaging community."

By increasing the magnification of the image to reduce the number of photons detected in each image pixel, they were able to significantly reduce the camera noise and considerably lessen the deteriorative effect of pixilation.

In fact, the team managed to attain particle localization accuracy that was twofold higher than those obtained with conventional EMCCD imaging.

Ober and his team applied UAIM (Ultrahigh Accuracy Imaging Modality) to the live-cell tracking of a standard protein marker for breast cancer. By being able to accurately follow the movement of the marker, valuable insights on the biology of breast cancer could be gained.

"The tracking of individual proteins represents an important way to study cancer and other diseases at the molecular level," Ober said. "The applications of UAIM for diagnostics and research are promising."


'/>"/>

Contact: Katherine Morales
kxm109320@utdallas.edu
972-883-4321
University of Texas at Dallas
Source:Eurekalert

Related medicine news :

1. Researchers tackle physician challenge of correctly ordering laboratory tests
2. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
3. Brain Circuitry Yields Clue to Autism, Researchers Say
4. NIH-supported researchers identify new class of malaria compounds
5. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
6. Mayo Clinic researchers develop test to gauge severity of concussions
7. University of Maryland researchers identify fish protein that may inhibit cancer metastasis
8. UCLA researchers create tomatoes that mimic actions of good cholesterol
9. Researchers identify a promising target for multiple sclerosis treatments
10. Spanish researchers link cancer to failures in chromosome protection for the first time
11. Researchers devise hidden dune filters to treat coastal stormwater runoff
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... , ... US Sports Camps has collaborated with State Rugby Organization (SRO), Rugby ... summer. Employing world-class rugby figures, including former Team USA players and college coaches, this ... fundamentals, match play, fitness and more. , “US Sports Camps is honored to be ...
(Date:5/6/2016)... ... 06, 2016 , ... Logically, spring weather, with its moderate humidity and temperatures, ... cold, dry or hot, water on the eye surface can evaporate, creating uncomfortable dry ... air. There’s only one problem, according to radio show and water advocate Sharon Kleyne: ...
(Date:5/6/2016)... York, NY (PRWEB) , ... May 06, 2016 , ... ... Hotel & Resort on the north end of the island close to the town ... July 17th- August 10th 2016. , “We continue to have an amazing experience ...
(Date:5/6/2016)... ... May 06, 2016 , ... ... of career-focused education and corporate training, and the National Military Family Association, a ... Maritza Aquino as the second full-tuition scholarship recipient of 2016. , “Being ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... TransWipe Volume ... Cut Pro X. Drag and drop a TransWipe preset between two video clips to ... smooth corner wipes to colored panels with customizable color and orientation options. TransWipe Volume ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016 BioNovus Innovations LLC and ... Advancing Medical Innovation (IAMI) today announced a new ... and medical devices. An agreement between ... to license, develop and commercialize medical innovations advanced ... "This partnership represents a significant advance in our ...
(Date:5/3/2016)...  As a teenager, an active and athletic ... his heart. He continued enjoying sports and recreation throughout ... heart was giving out and he was a few ... the Mesa, Arizona resident received ... heart transplant, the SynCardia TAH-t is the only approved ...
(Date:5/3/2016)... ORANGE COUNTY, Calif. , May 3, 2016  While you may be familiar with watching ... 4K resolution , also known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is ... class manufacturer of innovative technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: