Navigation Links
Researchers' new method may sharpen microscopic images
Date:3/21/2013

UT Dallas researchers are developing a new low-light imaging method that could improve a number of scientific applications, including the microscopic imaging of single molecules in cancer research.

Electrical engineering professor Dr. Raimund Ober and his team recently published their findings in the journal Nature Methods. In the journal, they describe a method which minimizes the deterioration of images that can occur with conventional imaging approaches.

"Any image you take of an object is translated by the camera into pixels with added electronic noise," Ober said. "Any distortion of an image makes it harder to obtain accurate estimates of the quantities you're interested in."

This method could greatly enhance the accuracy with which quantities of interest, such as the location, size, and orientation of an object, are extracted from the acquired images.

Ober and his team tackled this problem by using the EMCCD camera (a standard low-light image detector) in a highly unconventional setting. Using this method, scientists can estimate quantities of interest from the image data with substantially higher accuracy than those made with conventional low-light imaging.

"We have figured out through rigorous theoretical developments that when you run an EMCCD camera in such a way that very few photons hit each of its pixels, the resulting image is minimally corrupted by the camera noise," he said. "Our method is about using the EMCCD camera to its fullest potential, beyond what is commonly believed to be possible by the scientific imaging community."

By increasing the magnification of the image to reduce the number of photons detected in each image pixel, they were able to significantly reduce the camera noise and considerably lessen the deteriorative effect of pixilation.

In fact, the team managed to attain particle localization accuracy that was twofold higher than those obtained with conventional EMCCD imaging.

Ober and his team applied UAIM (Ultrahigh Accuracy Imaging Modality) to the live-cell tracking of a standard protein marker for breast cancer. By being able to accurately follow the movement of the marker, valuable insights on the biology of breast cancer could be gained.

"The tracking of individual proteins represents an important way to study cancer and other diseases at the molecular level," Ober said. "The applications of UAIM for diagnostics and research are promising."


'/>"/>

Contact: Katherine Morales
kxm109320@utdallas.edu
972-883-4321
University of Texas at Dallas
Source:Eurekalert

Related medicine news :

1. Researchers tackle physician challenge of correctly ordering laboratory tests
2. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
3. Brain Circuitry Yields Clue to Autism, Researchers Say
4. NIH-supported researchers identify new class of malaria compounds
5. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
6. Mayo Clinic researchers develop test to gauge severity of concussions
7. University of Maryland researchers identify fish protein that may inhibit cancer metastasis
8. UCLA researchers create tomatoes that mimic actions of good cholesterol
9. Researchers identify a promising target for multiple sclerosis treatments
10. Spanish researchers link cancer to failures in chromosome protection for the first time
11. Researchers devise hidden dune filters to treat coastal stormwater runoff
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
Breaking Medicine Technology: