Navigation Links
Researchers mimic body's own healing potential to create personalised therapies for inflammation
Date:4/4/2011

Scientists at Barts and The London School of Medicine and Dentistry and Harvard Medical School, Boston have found a way of mimicking the body's natural mechanism of fighting inflammation. During inflammation cells release very small particles termed 'microparticles' that retain features of their parent cell. The scientists discovered that certain microparticles were beneficial to health, and that these microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

The discovery, featured online in the current edition of the Journal of Immunology, paves the way for new personalized treatments to target uncontrolled inflammation that need not rely on synthetic biomaterials, therefore reducing potential toxicity.

Inflammation of joints and muscles is implicated in many human diseases including cardiovascular disease, arthritis and temporomandibular disorders and its treatment remains an unmet medical need.

Led by Dr Lucy V Norling (a Foundation Fellow of the Arthritis Research UK), researchers from the William Harvey Research Institute at Barts and The London School of Medicine and Dentistry and Harvard Medical School (laboratory of Professor CN Serhan) investigated the properties of microparticles during inflammatory episodes showing them to contain beneficial lipids (fat molecules) that are precursors for compounds that stimulate the resolution of an inflammatory episode. The researchers then mimicked this natural communication process to make a new personalized delivery system for anti-inflammatory therapeutics based on natural human microparticles instead of synthetic biomaterials, which bring adverse immunotoxic effects.

The many benefits of these humanized particles, coined 'nano-proresolving medicines' are that they can be loaded with anti-inflammatories (e.g. resolvins or other small molecules) to enhance their protective bioactions.

Dr Norling said: "These results uncover a novel way of targeting anti-inflammatories therapeutics to the site of inflammation using a natural delivery system. I think this new mode of delivery could have application for numerous inflammatory diseases including those of the joint such as arthritis and temporomandibular disorders. "


'/>"/>

Contact: Alex Fernandes
a.fernandes@qmul.ac.uk
44-207-882-7910
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. BATTLE researchers identify new biomarkers for EGFR inhibition
2. Researchers need to engage lesbian, gay, bisexual, and transginder populations in health studies
3. Researchers publish molecular disease model for melanoma
4. Researchers find possible clues to tamoxifen resistance in breast cancer patients
5. UCSF researchers identify promising new treatment for childhood leukemia
6. Researchers make the leap to whole-cell simulations
7. Stepchildren relate to stepparents based on perceived benefits, researchers find
8. Researchers find many elderly men are undergoing unnecessary PSA screenings
9. AACR and Landon Foundation support the next generation of researchers with INNOVATOR Awards
10. Can you hear me now? Researchers detail how neurons decide how to transmit information
11. AACR honors eminent researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... ... with leading global lifestyle design firm kathy ireland® Worldwide for five additional years, ... Worldwide entered into an exclusive licensing agreement three years ago to design and ...
(Date:12/5/2016)... Louis, Missouri (PRWEB) , ... December 05, 2016 ... ... across ethnic, gender, and geographic lines. The goal of Castlewood Treatment Centers has ... disorder treatment accessible to as many people as possible. In that spirit, ...
(Date:12/5/2016)... ... December 05, 2016 , ... Florida ... Florida Hospital West Florida Region. McGuinness brings experience in executive leadership and clinical ... physicians and leaders. , In her new role, that officially begins December 12, ...
(Date:12/5/2016)... ... 2016 , ... Sabah Shah MD, MBA has joined the Retina Group of New York ... founded by James M. Maisel, MD and has been providing tertiary medical and surgical retinal ... legacy of surpassing expectations amongst her peers. Growing up in a family of doctors, ...
(Date:12/5/2016)... ... December 05, 2016 , ... Z-Medica, LLC, a leading ... with The American College of Surgeons (ACS) to provide basic bleeding control instructor ... Control Basic” course is a pilot program that fulfills the intent of the ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016 Research and Markets has announced the addition ... to 2021" report to their offering. ... , , The global spinal ... 2021, at a CAGR of 5.3% from 2016 to 2021. Factors such ... cases, increasing government spending on healthcare, and rising income levels are propelling ...
(Date:12/5/2016)... , December 5, 2016 ... to Deputy Chairman   ... selectively targeting deubiquitylating enzymes (DUBs) to treat cancer, neurodegenerative and ... been appointed as non-executive Chairman, effective January 1 st ... Mission Therapeutics as a non-executive Director in July 2015. ...
(Date:12/4/2016)... Attorney General of Louisiana , Charles ... firm of Kahn Swick & Foti, LLC ("KSF"), announces that ... LCI ). On November 3, ... in Generic-Drug Probe to Be Filed by Year-End," which reported ... two years ago, now spans more than a dozen companies," ...
Breaking Medicine Technology: