Navigation Links
Researchers map genomic differences in yellow fever, malaria mosquitoes
Date:6/17/2014

Virginia Tech entomologists have developed a chromosome map for about half of the genome of the mosquito Aedes agypti, the major carrier of dengue fever and yellow fever.

With the map, researchers can compare the chromosome organization and evolution between this mosquito and the major carrier of malaria, the Anopheles gambiae mosquito, to find ways to prevent diseases.

"Despite looking somewhat similar, these mosquitoes diverged from each other about 150 million years ago. So, they are genetically further apart than humans and elephants," said Maria Sharakhova, a research scientist in the College of Agriculture and Life Sciences, a Fralin Life Science Institute affiliate, and the principal investigator of the study published in BMC Biology and highlighted on Biome.

The researchers say that the genome of the malaria mosquito is clearly separated into gene-rich and gene-poor compartments, while the genome of the yellow fever mosquito has no such differentiation. The study supports the observation that sex determination is also handled differently in the two mosquito species which could be useful in devising prevention measures.

In the malaria mosquito, X and Y chromosomes determine sex, but in the yellow fever mosquito, sex in males is determined just by a small location on chromosome 1.

Despite these differences, sex chromosome X in the malaria mosquito and chromosome 1 in the yellow fever mosquito evolve much faster than other chromosomes, meaning that the sex-determining segment of chromosome 1 may influence the rate of the change.

The discovery is significant because only female mosquitoes bite and transmit infectious diseases. Understanding the mechanisms of the sex chromosomes may help to manipulate the sex ratio in mosquitoes and reduce disease transmission.

"The development of novel approaches to disease control will be definitely more successful if we better understand the differences and similarities in the genomes of the yellow fever and malaria vectors," Sharakhova said.

Although the genome of the yellow fever mosquito was published in 2007, the lack of a detailed physical genome map prevented researchers from analyzing the chromosome genetic composition and evolution. The large size of the yellow fever mosquito's genome about one third of the human genome size and five times larger than the malaria mosquito's genome complicated genomic mapping efforts.

"The physical genome map developed in this study will guide efforts to significantly improve the genome assembly for the yellow fever mosquito and will facilitate more advanced studies of the genome organization and chromosome evolution in mosquitoes," said Igor Sharakhov, an associate professor of entomology in the College of Agriculture and Life Sciences, a Fralin Life Science Institute affiliate, and co-author on the paper.


'/>"/>

Contact: Lindsay Taylor Key
ltkey@vt.edu
540-231-6594
Virginia Tech
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways to cook a hot ... suggests that Americans prefer their dogs straight off the grill. Of the 90 percent ... favorite way to cook a hot dog, far outpacing other cooking methods such as ...
(Date:5/26/2016)... ... , ... Connor Sports, through its Connor Cares initiative, will continue ... Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and ... forms and levels of the game, Connor Sports has committed to a significantly increased ...
(Date:5/26/2016)... ... ... MadgeTech will be showcasing its line of data logging products , ... MadgeTech headquarters. With products sold in more than 100 countries around the world, MadgeTech ... , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data loggers around ...
(Date:5/26/2016)... ... May 26, 2016 , ... Memorial Day Weekend marks the ... Insurance is sharing tips to make sure your family and vehicle are ready ... Safety Council, there may be 439 deaths and an additional 50,500 serious injuries from ...
(Date:5/26/2016)... Rafael, CA (PRWEB) , ... May 26, 2016 ... ... will be offering campers a multitude of activities from daily practices, arts & ... self-confidence. , Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 MedDay, a biotechnology ... that an oral presentation entitled "High doses of biotin in ... will be given by Professor Ayman Tourbah , Principal ... of the European Academy of Neurology (EAN) in ... disorders 3" will take place on Sunday, 29 May 2016 ...
(Date:5/24/2016)... 24, 2016   ... primären Endpunkte und demonstriert Ebenbürtigkeit bei ... ‚ausgezeichneter plus guter , ...      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ) ... positive Daten von der MORA-Studie der Phase III ...
(Date:5/24/2016)... May 24, 2016 Celsion Corporation (NASDAQ: ... company, today provided an update on its ongoing ... trial combining GEN-1, the Company,s DNA-based immunotherapy, with ... newly-diagnosed patients with advanced ovarian cancer who will ... GEN-1 is an IL-12 DNA plasmid vector formulated ...
Breaking Medicine Technology: