Navigation Links
Researchers map all the fragile sites of the yeast Saccharomyces cerevisiae's genome
Date:2/9/2010

Montral, February 8, 2010- The research group of Dr. Franois Robert, a researcher at the Institut de recherches cliniques de Montral (IRCM), in collaboration with the team of Dr. Daniel Durocher (Samuel Lunenfeld Research Institute and University of Toronto) accomplished a technical breakthrough: they mapped all the fragile sites of a living organism, the budding yeast Saccharomyces cerevisiae. The method used by the researchers can be applied to humans. This study has been published online today in the scientific journal Nature Structural and Molecular Biology.

S. cerevisiae is a model organism commonly used in molecular biology to study basic cellular phenomena such as the regulation of gene expression, DNA replication or, as in the present case, DNA repair. DNA, which forms the genetic material of our cells, is continuously under stress challenging its integrity. On average, the DNA contained in each one of our cells suffers, on a daily basis, about 1 million damages. If not repaired, those genetic damages can lead to cancers. Hopefully, each cell has mechanisms that detect and then repair these injuries. It has long been known that some areas of the genome were more susceptible to be damaged than others. However, a complete list of those fragile areas had not been drafted until now.

The researchers made an unexpected discovery as they analyzed the newly identified fragile sites. They found that many of those fragile sites were located in regions of the genome that contained inactive genes. "This observation was quite surprising, commented Dr. Robert, because previous studies suggested, on the contrary, that the most active genes were more at risk." Pushing their investigation further, the scientists found that the way in which inactive genes were "wrapped" was what made them most fragile. "Inactive genes are wrapped more tightly than active genes, and our results suggest that this wrapping makes them more vulnerable. Thi
'/>"/>

Contact: Dr. Franois Robert
Francois.Robert@ircm.qc.ca
514-987-5737
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... children to help with chores while they are home from ... boosts self-esteem, and above all, helps parents maintain a somewhat ... how do you encourage your children to want to help? ... Child Development Journal, there is. The study found that adults’ ... to lend a hand. , The study found that ...
(Date:11/27/2014)... "The uglier, the better," says Dr. Kirk Kimmerling. ... of laughter as we enjoy the ugly sweater contest." ... from scratch. " It was a sight to see. ... ridiculous enough, the Christmas balls were faces of the staff ... in participating this year, it's simple to get in on ...
(Date:11/27/2014)... India (PRWEB) November 27, 2014 Ethane ... company, has announced online reputation management service. ... a comprehensive study about the world of internet marketing ... and Yahoo. , Ethane Web Technologies does not ... it first analyzes the project to reach a conclusion ...
(Date:11/27/2014)... November 27, 2014 Ethane Web Technologies, an ... will provide a 10% Christmas discount on PPC service. The ... The discount offer will begin on 1 December 2014 and ... About this offer, a PPC professional working at Ethane Web ... for small businesses, as this big discount would make the ...
(Date:11/27/2014)... 26, 2014 Lintelus, Inc., an ... focused on increasing audience engagement at Convergence Summit ... software platform includes a multitude of interactive features ... a collaborative, interactive multi-screen environment. Best of all, ... in real time on their own device. , ...
Breaking Medicine News(10 mins):Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 3Health News:Ethane Web Technologies Announces Online Reputation Management Service 2Health News:Ethane Web Technologies Announces 10% Christmas Discount on PPC Service 2Health News:Lintelus Showcases its Feature-Rich Presentation Technology Solution at Convergence Summit’s Annual Event in London 2
... way mothers interact with their babies in the first year ... on. Both a mother,s parenting style and an infant,s temperament ... Lahey and his team from the University of Chicago in ... in Springer,s Journal of Abnormal Child Psychology . , ...
... As part of an initiative to,give back to ... its annual,scientific meetings, the American Society for Therapeutic ... Community - Greater Boston,to raise awareness of cancer ... will join forces with ASTRO by,participating in the ...
... announced today that it has opened a Center for ... Company,s third in the state of,California, one of many ... this location represents the 7th new Center opened in ... According to the National Institute of Health, the ...
... of EP and large untreated patient population to drive ... market, according to Millennium Research Group, ... market will grow significantly over the next five years, ... treatment of cardiac,arrhythmias (a disorder that causes abnormal heart ...
... for Terrorism Preparedness and ... Emergency Response, ... was,selected by the Centers for Disease Control and Prevention (CDC) to ... Emergency Response (COTPER) in Atlanta. This,task order has one base year ...
... N.J., June 23 The American Society of,Transplantation ... the 2008-2009,board of directors. The officers were introduced ... Toronto, Canada, in May., The officers are: ... Medicine; president-elect, Joren C. Madsen, M.D., D.Phil.,Massachusetts General ...
Cached Medicine News:Health News:Mothers' influence is decisive in tots' first year 2Health News:ASTRO, The Wellness Community - Greater Boston Join to Promote Cancer Survivorship 2Health News:CRH Medical Corporation opens Center in San Diego California 2Health News:Chinese Electrophysiology Market to Grow at a CAGR of 20% Over the Next Five Years 2Health News:Lockheed Martin Wins $24 Million IT Contract With CDC 2Health News:The American Society of Transplantation Announces 2008-2009 Board of Directors 2
(Date:11/26/2014)...  Thoratec Corporation (NASDAQ: THOR ), a ... save, support and restore failing hearts, said today it ... On Tuesday, December 2, the company will participate ... Conference.  D. Keith Grossman , President and Chief ... beginning at 11:30 a.m., Eastern Standard Time (8:30 a.m., ...
(Date:11/26/2014)...  Perrigo Company plc ("Perrigo") (NYSE: PRGO ... Healthcare Products®," today announced the closing of Perrigo,s previously ... 6,809,210 ordinary shares at a public offering price of ... option to purchase up to an additional 888,157 ordinary ... Inc., as representatives of the several underwriters. ...
(Date:11/26/2014)... WOODLANDS, Texas , Nov. 26, 2014 /PRNewswire/ ... ) today announced the completion of previously announced ... $280.0 million.  After fees and estimated offering expenses, ... from the transactions.  The transactions consisted of: ... of common stock, pursuant to a registration statement ...
Breaking Medicine Technology:Thoratec Announces Presentations At Investor Conferences For December 2014 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3
... Multi-Center Phase 1 Trial to Commence -, ... Sheets: ARDC), a company focused on the discovery ... viral,diseases, cancer and inflammatory diseases, today announced that ... status to the,Investigational New Drug (IND) application for ...
... Center of the San Francisco Bay research seeks couples ... ... Reproductive Science Center,of the San Francisco Bay Area, in ... evaluate the safety and effectiveness of,ViaCyte, an investigational product intended ...
Cached Medicine Technology:Ardea Biosciences' Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients 2Ardea Biosciences' Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients 3Bay Area Women Sought for Egg Freezing Study 2
... PCE PC-Based Exercise ECG Systems offer clinical ... provide advanced database functionality for paperless storage. ... the Welch Allyn PCE Exercise ECG software ... test system. And with its ability to ...
Versatile and Affordable: The Quinton Q-710 ECG system is a versatile and affordable ECG cart that can be configured to meet your specific needs. It can be set on a counter top or mounted on a sturd...
... testing system from Del Mar Reynolds Medical. ... or bicycle ergometer, PC, Cart, isolation transformer ... the same CardioDirect patient interface module that ... ,The system is also available using the ...
... ECT WS 2000 is designed to monitor, store ... provocative tests, (stress-testing). The system can organize the ... provide them for a quick review and printout ... recorded ECG is transmitted via a small portable ...
Medicine Products: