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Researchers map, measure brain's neural connections
Date:6/1/2011

PROVIDENCE, R.I. [Brown University] Medical imaging systems allow neurologists to summon 3-D color renditions of the brain at a moment's notice, yielding valuable insights. But sometimes there can be too much detail; important elements can go unnoticed.

The bundles of individual nerves that transmit information from one part of the brain to the other, like fiber-optic cables, are so intricate and so interwoven that they can be difficult to trace through standard imaging techniques. To help, computer science researchers at Brown University have produced 2-D maps of the neural circuitry in the human brain.

The goal is simplicity. The planar maps extract the neural bundles from the imaging data and present them in 2-D a format familiar to medical professionals working with brain models. The Brown researchers also provide a web interface by integrating the neural maps into a geographical digital maps framework that professionals can use seamlessly to explore the data.

"In short, we have developed a new way to make 2-D diagrams that illustrate 3-D connectivity in human brains," said David Laidlaw, professor of computer science at Brown and corresponding author on the paper published in IEEE Transactions on Visualization and Computer Graphics. "You can see everything here that you can't really see with the bigger (3-D) images."

The 2-D neural maps are simplified representations of neural pathways in the brain. These representations are created using a medical imaging protocol that measures the water diffusion within and around nerves of the brain. The sheathing is composed of myelin, a fatty membrane that wraps around axons, the threadlike extensions of neurons that make up nerve fibers.

Medical investigators can use the 2-D neural maps to pinpoint spots where the myelin may be compromised, which could affect the vitality of the neural circuits. That can help identify pathologies, such as autism, that brain scient
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Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

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