Navigation Links
Researchers make the invisible visible
Date:2/24/2014

The 2003 development of the so-called hyperpolarization technique by a Danish research was a groundbreaking moment that made it possible to see all the body's cells with the help of a new contrast agent for MRI scans. Researchers from Aarhus have now taken another big step towards understanding the body's cells and with it also the development of diseases:

"With the hyperpolarization method, sensitivity to specific contrast agents is up to 10,000 times higher than with a traditional MRI scanning. What we have now documented is that with the hyperpolarization MRI scanning we can not only see the differences in the metabolic patterns between healthy and ill, but we now can also see the metabolic changes as a consequence of acute influences while they are taking place in the diabetic kidneys. It is really groundbreaking," says Assistant Professor Christoffer Laustsen from Aarhus University.

The discovery stems from a study of the correlation between oxygen level and the development of kidney disease in rats with and without diabetes. The findings have just been published in the prestigious international journal Kidney International.

Tailored treatment

Though the advanced hyperpolarization technique has initially been utilised to document metabolic changes in the kidneys, it will be possible to use it to gain a greater insight into the development of diseases in all of the body's organs:

"With this method we will have a fingerprint of the cells and we will be able to follow whether these fingerprints change over time, regardless of which organs we examine. We will, for example, be able to see whether complications related to diabetes and cardiovascular diseases are emerging, or how a cancer tumour develops," says Christoffer Laustsen and continues:

"And with greater knowledge of what is always going on at the cellular level we will be able to make a diagnosis earlier than we can today, and we will also be able to tailor treatment to the individual patient to a greater extent."

Better diagnosis of childhood diseases

The advantage of hyperpolarization scanning is not only that it provides the researchers with much greater detail about what is going on in the body. The new method can also prove to be very important for the smallest patients in particular:

"Another great advantage of this method is that this is quite harmless. The contrast agent for the hyperpolarization scanning is sugar-based, so there is no risk of the body tissues being exposed to radiation. It will therefore be possible to scan children more often than today," says Christoffer Laustsen.

He has carried out the study with fellow researchers from Aarhus University, Aarhus University Hospital, the Technical University of Denmark, Hvidovre Hospital and Uppsala University.

The studies of metabolic changes at the cellular level have so far been carried out on rats. Christoffer Laustsen however expects that researchers in Denmark - which is one of the leading countries in Europe in the area - will be ready to offer diagnostic examination of patients within 2-3 years.


'/>"/>

Contact: Christoffer Laustsen
cl@mr.au.dk
45-78-45-61-06
Aarhus University
Source:Eurekalert  

Related medicine news :

1. Researchers look for culprit behind oral health problems in HIV-positive patients
2. Clemson researchers develop sticky nanoparticles to fight heart disease
3. NUS researchers make new discovery of protein as a promising target for treatment of ATC
4. Scripps researchers recommend mobile compression device to prevent DVT after joint surgery
5. No such thing as porn addiction, researchers say
6. LA BioMed researchers report on promising new therapy for devastating genetic disorder
7. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
8. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
9. Researchers discover new hormone receptors to target when treating breast cancer
10. Kessler Foundation MS researchers study predictors of employment status
11. RI Hospital researchers identify components in C. diff that may lead to better treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers make the invisible visible
(Date:4/21/2017)... ... 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. Shah, MD ... a benign bony lump located on the forehead usually attributed to a facial fracture. ... and pain. Dr. Shah has discovered an approach that is minimally invasive. He is ...
(Date:4/21/2017)... Horsham, PA (PRWEB) , ... April 21, 2017 , ... ... The new identity emphasizes the agency’s conviction that the full potential of specialty and ... HCPs are equally appreciated and aligned. , “The Unifying Effect is at the ...
(Date:4/21/2017)... ... April 21, 2017 , ... The Hong Kong Polytechnic University (PolyU) ... facility among higher education institutions in Hong Kong to support teaching, learning and research. ... range and quantity of facilities in Hong Kong. , With an area of ...
(Date:4/21/2017)... ... April 21, 2017 , ... Airway Management, the medical device ... highly regarded and well renowned Asian distributor, Discovery Sleep. The agreement ... Pillow Mask, and will stabilize and strengthen Airway’s presence with a dedicated, reputable ...
(Date:4/21/2017)... ... , ... Providing for loved ones before one’s passing is of paramount importance. ... begin. “Now more than ever there are some questions that are far too critical ... said attorney Lisa Edgar Dickman, founder of the Law Offices of Lisa Edgar Dickman. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... DIEGO , April 19, 2017  Sorrento ... an antibody-centric, clinical-stage biopharmaceutical company developing new treatments ... announced the closing of its previously announced underwritten ... stock at a public offering price of $2.00 ... and estimated offering expenses payable by Sorrento.  The ...
(Date:4/19/2017)... HANOVER, N.J. , April 19, 2017 /PRNewswire/ ... conducted by the National Heart, Lung, and Blood ... (NIH) demonstrating that 58% of patients with treatment-naïve ... six months when treated with eltrombopag at the ... 1 . The study evaluated three sequential treatment ...
(Date:4/18/2017)... Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical device ... markets with innovative and proprietary products, will release financial ... after the market close on Tuesday, May 2, 2017. ... call and webcast to discuss its financial results the ... p.m. Eastern Time (3:30 p.m. Central Time). Darin ...
Breaking Medicine Technology: