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Researchers make promising discovery in pursuit of effective lymphoma treatments
Date:5/16/2012

rch team from NYU School of Medicine has shown that, by blocking GSK3 from phosphorylating p100, it is possible to prevent the degradation of p100, which then blocks the NF-кB pathway, thereby halting gene transcription and blocking tumor cells' safe zone. Alternatively, pharmaceutical research may find a way to target Fbxw7α, which would keep the pathway turned off in the same way.

"Cancers are persistent and tenacious," Dr. Pagano said. "There are millions of pieces to the puzzle of how they work and we've discovered a few more pieces of that puzzle. It is very possible that we can find an inhibitor of Fbxw7α since there are already drugs being tested that inhibit very similar enzymes."

Moreover, Dr. Pagano explained, it is likely that the effects observed in multiple myeloma may be generalized to other B-cell neoplasms, types of lymphomas, especially those in which the tumor cells hide out in the NF-кB pathway.

"These new findings strongly suggest that by targeting this enzyme, we will kill multiple myeloma cells and other B-cell lymphomas," he said. "And that, from a researcher's perspective, is a very exciting prospect."


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Contact: Jessica Guenzel
jessica.guenzel@nyumc.org
212-404-3591
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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