Navigation Links
Researchers make promising discovery in pursuit of effective lymphoma treatments
Date:5/16/2012

ctive pathway, the lymphoma cells are able to evade apoptosis, or cell death, allowing them to proliferate in an uncontrolled way.

"Activating mutations in the NF-кB pathway does not generally represent the initial oncogenic event," Dr. Pagano said. "But they are necessary for the survival and spread of the cancer."

Dr. Pagano explained the steps involved with pathway's activation and deactivation in more scientific detail: The process begins in the pathway's off state, with the accumulation of p100. To clear the pathway and naturally turn it back on, a sequence of events has to happen. First, a kinase, which the team identified as GSK3, phosphorylates p100. The phosphorylation draws the attention of Fbxw7α, a subunit of a ubiquitin ligase, which binds to the portion of p100 that has been phosphorylated by GSK3. The addition of Fbxw7α to the p100 protein then causes ubiquitin to seek out p100. Ubiquitin attaches to the protein and modifies it in a way such that it is recognized by a protease whose job it is to recognize and degrade any protein that has been modified by ubiquitin conjugation. As a result, p100 is degraded in the nucleus of the cell and the pathway is cleared and activated, turning on the gene transcription signal.

These new findings lead the researchers to conclude that the intersection of GSK3, Fbxw7α and p100 may serve as a potential intervention point for the treatment of multiple myeloma. Researchers believe if they can find a way to target the elimination of p100 they may be able to inactivate the pathway, which would eliminate the tumor cells' safe haven so that they would be susceptible to apoptosis. This would in turn promote the death of multiple myeloma cells.

According to Dr. Pagano, this strategy may not be too far from becoming a reality. There are already drugs being tested in clinical trials for Alzheimer's Disease that work by inhibiting GSK3. With the current study, the resea
'/>"/>

Contact: Jessica Guenzel
jessica.guenzel@nyumc.org
212-404-3591
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
2. New biomarker test predicts arthritis at much earlier stage, MU researchers say
3. Researchers Test Laxative-Free Colon Scan
4. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
5. Researchers discover how to overcome poor response to radiotherapy caused by low haemoglobin levels
6. Researchers see BPA effects in monkey mammary glands
7. Geisel researchers sift through junk to find colorectal cancer clues
8. Email vacations decrease stress, increase concentration, researchers say
9. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
10. CNIO researchers describe new functions of cohesin relevant for human disease
11. Biomedical researchers receive Hartwell Foundation awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... Anik Singal's Profit Academy - a ... has become the talk of the town throughout ... the course's general release has garnered the attention ... to review the program's content and publish an ... keys to success with Internet marketing is having ...
(Date:3/3/2015)... 2015 On February 21st, the rooftop ... EcoLuxe Lounge, a day-long event that features a gathering ... and services. Organized by Debbie Durkin and Durkin Entertainment, ... producer, the EcoLuxe Lounge saw many notable attendees. Among ... General Hospital, The Flash, Star Trek: Deep Space Nine ...
(Date:3/3/2015)... Findings could lead to better therapies ... have developed and characterized a molecule that interferes with ... self-destruct. This novel mechanism was found to be effective ... type of brain cancer – and could be applicable ... to be published in the April 2015 issue of ...
(Date:3/3/2015)... The Rheumatology Nurses Society (RNS) is ... and safe practice for patients with rheumatic diseases. , ... infusions are administered in an infusion center, provider’s office, ... nurse (RN), as defined in their State Nurse Practice ... receiving these medications during a first infusion, as well ...
(Date:3/3/2015)... The report “Alopecia – Pipeline Review, H1 ... Alopecia. Alopecia is the loss of hair. Alopecia areata ... alopecia. Causes for alopecia include aging, genetics, illness, chemotherapy, ... male pattern hair loss, female diffuse hair loss, hairs ... as focal or diffuse and by the presence or ...
Breaking Medicine News(10 mins):Health News:Anik Singal's Profit Academy - Review Of New IM Training Program Released 2Health News:Hollywood Star Chase Masterson and Choices Recovery Discuss Substance Abuse and Treatment at 2015 Oscars 2Health News:News: UC Davis Scientists Describe Novel Drug Mechanism That Fights Brain Cancer 2Health News:News: UC Davis Scientists Describe Novel Drug Mechanism That Fights Brain Cancer 3Health News:News: UC Davis Scientists Describe Novel Drug Mechanism That Fights Brain Cancer 4Health News:Administration of Biologic Infusions: A Position Statement of the Rheumatology Nurses Society 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4
... Nov. 19 Mangos, a full-service advertising,agency, recently received ... a leading healthcare publication. The competition recognizes,exceptional creativity ... for the first time this year, and was the ... (Photo: http://www.newscom.com/cgi-bin/prnh/20081119/AQW573 ...
... 19 Governor Edward G. Rendell today revised his ... Health Care Cost Containment Council (PHC4). Under the revised order, ... or until the General Assembly reauthorizes the council, whichever occurs ... Governor acted similarly in 2003 when PHC4 was allowed to ...
... ALEXANDRIA, Va., Nov. 19 Recognizing November 20th as ... Cancer Society, the National Community Pharmacists Association House of ... to consider refraining from selling tobacco products in their ... pharmacies are renowned for helping their patients to maintain ...
... Consumer Watchdog said the health insurance industry,s support today ... it includes a requirement that every American buy insurance ... self-serving. The proposal amounts only to a customer delivery ... will not solve America,s health care problems and will ...
... Methodist University in Dallas are pioneering the use of ... Persian Gulf War veterans, aiming to pinpoint specific areas ... , Richard Gunst, Wayne Woodward and William Schucany, professors ... specialists at UT Southwestern Medical Center to compare brain ...
... And more is coming. At The University of Texas ... trainees are learning how to address the many issues ... received a 5-year, $1.3 million grant from the Agency ... young investigators how to conduct research in health information ...
Cached Medicine News:Health News:Mangos Wins Two Gold Awards 2Health News:Governor Rendell Revises Executive Order; Extends Operation of PA Health Care Cost Containment Council 2Health News:Governor Rendell Revises Executive Order; Extends Operation of PA Health Care Cost Containment Council 3Health News:NCPA Encourages Member Pharmacists to Consider Refraining From Selling Tobacco Products 2Health News:Consumer Watchdog Comments on Health Insurer's Self-Serving Support of 'Individual Mandate' 2Health News:Deep brain mapping to isolate evidence of Gulf War syndrome 2Health News:UT trainees tackle health information technology issues 2Health News:UT trainees tackle health information technology issues 3
(Date:3/3/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lvsz93/telemedicine_and ) ... and Mobile Healthcare Solutions, Services, and Devices: Market ... to their offering. Telemedicine, Tele-health, ... pertain to the use of telecommunications and information ... services. They form the ecosystem that contains all ...
(Date:3/3/2015)... , March 3, 2015   VWR ... products, services and solutions, announced today the expansion ... Inc. (NEB®). This agreement allows VWR increased access ... support in the U.S. and Puerto Rico.  In ... products through VWR,s e-business platform, sales organization, and ...
(Date:3/3/2015)... SAN DIEGO and BETHESDA, Md. ... regenerative medicine company with the first stem cell-derived islet ... trials, today announced a presentation by Dr. Eugene ... at the JDRF TypeOneNation Summit.  The annual summit showcases ... treatments. Details of the presentation are as ...
Breaking Medicine Technology:Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 2Global Telemedicine and Mobile Healthcare Solutions, Services, and Devices: Market Analysis and Forecasts 2015 - 2020 3VWR Announces Expansion of Distribution Agreement with New England Biolabs 2ViaCyte to Present at JDRF TypeOneNation Research Summit 2
Triangular 0.5 mm angled tip with 4 mm flat surface. Round knurled handle with dull finish. Tip angle: 110o. Most popular size or model....
25 gauge cannula. 2 mm vertical spatula tip with opening on right side. 10 mm from tip to bend. Polished finish....
Angled blade and flat serrated handle with polished finish. Blade: 1 mm x 10 mm....
11 mm angled tip with gently curved blade. Flat serrated handle with polished finish....
Medicine Products: