Navigation Links
Researchers make critical leukemia stem cell discovery
Date:12/13/2010

eukaemia, in part by activation of beta-catenin. But suppression of beta-catenin in leukaemic stem cells reduced leukaemic cell growth, delayed the onset of leukaemia and reversed the stem cells to a pre-leukaemic stage. Furthermore, when beta-catenin was completely inactivated in mice with pre-leukaemic cells, the mice did not develop leukaemia, even though they carried MLL gene mutations.

Researchers then wanted to see how suppression of the beta-catenin protein impaired human leukaemic cells. They found that suppression of the protein in MLL leukaemic cells again diminished their ability to proliferate and renew themselves (an essential part of how leukaemia develops). This confirmed the important role of beta-catenin in the human disease.

The study also revealed a previously unrecognized critical function of beta-catenin in mediating drug resistant properties of leukaemic stem cells. Leukaemic stem cells can become resistant to treatment in some cases but, crucially, this study showed that suppression of beta-catenin in human MLL leukaemic cells made them sensitive again.

Professor Eric So, who led the study at King's, said: 'These results are extremely exciting and represent a critical step forward in the search for more effective treatments for this devastating form of leukaemia. The findings provide compelling evidence that this protein could be exploited to develop an effective therapeutic target for this form of the disease.

'Most of the current anti-cancer therapies used to treat leukaemia attack healthy blood cells as well as cancerous ones. Interestingly, beta-catenin is not required for normal blood stem cells. So if we can specifically target beta-catenin in the bone marrow, we can have potentially a more effective and less toxic anti-leukaemia therapy that can efficiently eradicate leukaemic stem cells but spares healthy blood stem cells.

'Much more research needs to be done before we can adopt this approach
'/>"/>

Contact: Emma Reynolds
emma.reynolds@kcl.ac.uk
44-207-848-4334
King's College London
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Anterior Cruciate Ligament (ACL) happens all too frequently, however ... Orthopaedic Society for Sports Medicine,s (AOSSM) Annual Meeting suggests ... may minimize the chance of a future ACL tear. ... factors such as, age, activity level and type of ... said lead author, Christopher C. Kaeding, MD of the ...
(Date:7/11/2014)... NY (PRWEB) July 11, 2014 Wild by ... is proud to announce they are opening a fifth store ... Wild by Nature offers one of the largest selections of ... people diagnosed with celiac disease, these stores have become a ... gluten-free diet. , Gluten sensitivity, and gluten intolerance, is a ...
(Date:7/11/2014)... BellasDress, the experienced dressmaker in the ... suppliers when it comes to beach wedding dresses ... of beach wedding outfits in its online shop. Included ... outfits. , BellasDress has been considered as one ... to the company’s senior spokesman, BellasDress provides superb special ...
(Date:7/11/2014)... Growing old was thought of as a fate that was ... was shown that many of the “myths” people associate with ... out, the elderly can still live quite as fruitfully as their ... time in the world, older people also need to live a ... the twilight of their lives. This is why Guy Coalter, the ...
(Date:7/11/2014)... July 11, 2014 Plasma resource reserves ... products industry. Although the closure of 16 plasma collection ... to domestic blood products market, the total plasma volume ... on year and total lot release volume declined by ... stock consumption, insufficient utilization of new plasma stations and ...
Breaking Medicine News(10 mins):Health News:Wild by Nature Opens New Location 2Health News:BellasDress Emerges As Popular Online Supplier Of 2014 Beach Wedding Dresses 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 3Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 2Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 3Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 4
... of your New Year resolutions, The Alliance for Aging Research// ... of both physical as well as mental exercise to stay ... nonprofit Alliance for Aging Research said, "There is a lot ... prevent or lessen the cognitive decline that often comes with ...
... habit of offering fruit juices and sugar added beverages ... better to avoid sugary drinks in cups with sippers ... the sipper attached. The American Academy of Pediatric Dentistry (AAPD) ... cups do help to avoid liquids from spilling over from ...
... for patients in ICU by adhering to simple techniques ... infections. // ICUs can become thoroughly aseptic by ensuring ... and catheters. A detailed report was made by experts ... the report are published in New England Journal of ...
... parents to encourage their children to put away the video ... AMA Vice President, Dr Choong-Siew Yong, said today. ... soccer balls and tennis racquets are a great way to ... ,“Swimming or horse-riding lessons, bicycle outings, backyard cricket, or just ...
... junta, left for Singapore to receive treatment for an intestinal ... who has led Myanmar's junta - the self-styled State Peace ... the country Sunday on a special flight arranged by businessman ... ,An informed source in the government said Than Shwe, ailing ...
... the calories a person consumes can prevent, or at least ... suggests// that body composition – whether a person is ... risks. ,In other words, how the body ... than how many or how few calories are consumed—a finding ...
Cached Medicine News:Health News:Simple Steps to Safe Guard Patients from Bloodstream Infections in ICU 2Health News:Keep Kids Active in the Holidays 2Health News:Body Composition Is Key Player in Controlling Cancer Risks 2
(Date:7/10/2014)... July 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... it has completed the sale to Galderma of all ... or held by Valeant for $1.4 billion in cash, ... which recently completed its acquisition of Galderma. ... our products to a company that is firmly committed ...
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:7/10/2014)... 2014 CVS Caremark Corporation (NYSE: CVS ... a quarterly dividend of $0.275 (27.5 cents) per share on ... 1, 2014, to holders of record on July 21, 2014. ... is dedicated to helping people on their path to better ... the United States . Through the company,s more than ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... 17 The Department of,Justice announced today that ... CEO,Roundtable on Cancer (CRC) to develop and publicize ... cancer treatments. The Department said,the language is not ... to help,increase efficiency in contract negotiations, potentially reducing ...
... (OTC Bulletin Board: BSTC), a biopharmaceutical company,developing first ... of a U.S. Phase IIb clinical trial in ... its partner Auxlium,Pharmaceuticals, Inc., "We are very ... this trial,into a Phase IIb based on our ...
Cached Medicine Technology:Justice Department Will Not Oppose CEO Roundtable on Cancer's Proposal 2BioSpecifics Technologies Corp. Announces Initiation of Phase IIb Trial for Peyronie's Disease 2BioSpecifics Technologies Corp. Announces Initiation of Phase IIb Trial for Peyronie's Disease 3
... with concave seats and standard-sized backrests ... like seats, backrests, armrests, and casters ... recommended for the following environments: industry, ... health care and office. • With ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
Medicine Products: