Navigation Links
Researchers link new molecular culprit to breast cancer progression
Date:11/26/2012

Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November 5 on the website of the Proceedings of the National Academy of Sciences, details how some tumors get the tools they need to metastasize.

"We've identified a protein that wasn't known before to be involved in breast cancer progression," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and director of the Vascular Program at Hopkins' Institute for Cell Engineering. "The protein JMJD2C is the key that opens up a whole suite of genes needed for tumors to grow and metastasize, so it represents a potential target for cancer drug development."

Semenza and his colleagues made their finding when they traced the activity of HIF-1, a protein known to switch on hundreds of genes involved in development, red blood cell production, and metabolism in normal cells. Previous studies had shown that HIF-1 could also be hijacked to switch on genes needed to make breast tumors more malignant.

Would-be tumor cells face a host of challenges as they make the transition from working with their host to working against it, such as the need to evade the immune system and to produce more cancer cells, explains Weibo Luo, Ph.D., an instructor in the Institute for Cell Engineering and Department of Biological Chemistry who led the project. All of these efforts require switching on the right genes for the job.

To learn more about how HIF-1 works, the researchers tested a range of human proteins to see whether they would interact with HIF-1. They then sifted through the 200 resulting hits, looking for proteins involved in chemical changes to sections of DNA that determine whether or not the genes they contain are available for use. "In order for HIF-1 to switch
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers discover gender-based differences in Alzheimers disease
2. Researchers find evidence that brain compensates after traumatic injury
3. Researchers find decline in availability and use of key treatment for depression
4. Researchers implicate well-known protein in fibrosis
5. Researchers build synthetic membrane channels out of DNA
6. JTCC researchers play important role in groundbreaking study that may change transplant practices
7. Researchers use computer simulations to find true cost of HIV screenings
8. Sleeping Pill Linked to Hospital Falls, Researchers Say
9. Daycare has many benefits for children, but researchers find mysterious link with overweight
10. Researchers outline effective strategies to prevent teen depression and suicide
11. Researchers report potential new treatment to stop Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... Philadelphia (PRWEB) , ... September ... ... global provider of high-quality patient safety and efficacy endpoint data collection, cloud ... Annual European PRO and eCOA Congress in Lisbon, Portugal, September 22-24, 2015. ...
(Date:9/3/2015)... ... September 03, 2015 , ... “Love in Tokyo” an independent ... Play , and Amazon and will be released on DVD early next ... is a Foreigner,” Itsuka, an actress and singer/songwriter, and Jason London, lead from “Dazed ...
(Date:9/3/2015)... ... , ... When looking at the types of people who have a hard time gaining ... have a weak appetite or those that have a fast metabolism. In order to help ... Gainer gives three tips for slowing down metabolism. , The first thing to do is ...
(Date:9/3/2015)... ... September 03, 2015 , ... Doctor Kayode Sotonwa can be counted ... there. His perspective on internal medicine keeps patients happy and healthy, something that is ... regardless of the season, but even more so in the fall, when holiday eating ...
(Date:9/2/2015)... ... 2015 , ... One can hardly argue against the fact that more and ... personal computers. These devices are being used as GPS, to make purchases, and yes, ... apps, STD positive singles can now join the prestigious social ranks of e-dating. ...
Breaking Medicine News(10 mins):Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 2Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 3Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 3Health News:Doctor Kayode Sotonwa Highlights Expert Tips for Staying in Shape This Fall 2Health News:Herpes-datingsites.com Recently Added Reviews of 5 STD Dating Apps for STD Positive Singles 2
... Needs of Life Science Companies, Health Care ProvidersLIBERTYVILLE, ... a leader in digital sales and marketing solutions, ... the nation,s leading provider of online, on-demand prescription ... a wholly owned subsidiary of Physicians Interactive LLC. ...
... Alliance Creates the Nation,s Largest Independent Online Retailer ... Million CustomersNEW YORK, March 24 Sandow Media, ... e-commerce Web site SpaLook.com, and Salu Beauty, parent ... deliver unprecedented scale and reach for beauty product ...
... Gather to Discuss Interactive Patient Care, Patient Engagement ... GetWellNetwork, Inc., the leading provider of ... highly successful conference, GetConnected2009 . ... GetConnected2009 is the industry,s leading annual ...
... Month , HARRISBURG, Pa., April 1 The Department ... for men and women to take steps to prevent ... well as the importance of discussing their sexual health ... are treatable, screening and early diagnosis are essential to ...
... at 5:00 p.m. EDT -- SOUTH SAN FRANCISCO, ... SNSS ) today announced the execution of a ... private placement of up to $43.5 million in a ... convertible preferred stock and common stock warrants, and a ...
... Medical Innovations, Inc. (NYSE: IMA ), a global ... at home through the merger of rapid diagnostics and health ... was elected to the company,s board of directors. Dr. Adashi, ... Care and in the Life Sciences was also appointed to ...
Cached Medicine News:Health News:Physicians Interactive Acquires MedManage Systems 2Health News:Physicians Interactive Acquires MedManage Systems 3Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 2Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 3Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 2Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 3Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 4Health News:Pennsylvania Department of Health Urges Greater Awareness of, Testing for Sexually Transmitted Diseases 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 3Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 4Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 5Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 6Health News:Eli Y. Adashi, MD, MS, FACOG, Joins Inverness Medical Innovations' Board of Directors 2
(Date:9/2/2015)...   About ELISA test ELISA test ... is used for measuring the concentration of analytes such ... various types of enzymes such as carbonic anhydrase, glucose ... by photometry or fluorometry. ELISA is used as a ... such as HIV, pernicious anemia, rotavirus, Rocky Mountain spotted ...
(Date:9/2/2015)... 2015 STAAR Surgical Company (NASDAQ: STAA ), ... delivery systems for the eye, today announced that its Board ... the Company,s Board. Mr. Wall was formerly ... -based investment firm, for more than nine years. Mr. ... and chair of the Corporate Governance Committee and member of ...
(Date:9/2/2015)... , Sept. 2, 2015 Research and ... the "Inhaled Drug Delivery (London, UK - November ... This Inhaled Drug Delivery meeting will cover industry case ... much more. The Co-Chairmen are Dr Steven Nichols ... Senior Director, Mylan. Companies participating include: ...
Breaking Medicine Technology:Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3William P. Wall Appointed to STAAR Surgical Board of Directors 2
... NEW YORK, Dec. 13, 2010 Pfizer Inc. (NYSE: ... Directors has elected George A. Lorch, 68, who has served ... the Board, effective immediately. (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) ... said, "George Lorch has been a valuable, independent voice on ...
... Company announced today that it has suspended its global ... compound, as a second-line treatment for those with unresectable ... with an independent data monitoring committee, recommended a "full ... hold ensures that no new or existing patients in ...
Cached Medicine Technology:Pfizer Board of Directors Elects George A. Lorch Non-Executive Chairman 2Lilly Suspends Phase III Trial in Metastatic Melanoma 2Lilly Suspends Phase III Trial in Metastatic Melanoma 3
... Solution For Your Tracheostomy Care Needs, ... features the latest components for efficient and ... task. Designed by clinicians, these latex-free trays ... patient and caregiver. All of our trays ...
... Medline Has the Right Solution For ... tracheostomy clean and care tray features the ... of this important infection control task. Designed ... the individual needs of each patient and ...
... and alternate care facilities with a ... which offer the finest in nursing ... the guidance of experienced nursing personnel, ... what is required for efficient and ...
... and alternate care facilities with a ... which offer the finest in nursing ... the guidance of experienced nursing personnel, ... what is required for efficient and ...
Medicine Products: