Navigation Links
Researchers link new molecular culprit to breast cancer progression
Date:11/26/2012

Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November 5 on the website of the Proceedings of the National Academy of Sciences, details how some tumors get the tools they need to metastasize.

"We've identified a protein that wasn't known before to be involved in breast cancer progression," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and director of the Vascular Program at Hopkins' Institute for Cell Engineering. "The protein JMJD2C is the key that opens up a whole suite of genes needed for tumors to grow and metastasize, so it represents a potential target for cancer drug development."

Semenza and his colleagues made their finding when they traced the activity of HIF-1, a protein known to switch on hundreds of genes involved in development, red blood cell production, and metabolism in normal cells. Previous studies had shown that HIF-1 could also be hijacked to switch on genes needed to make breast tumors more malignant.

Would-be tumor cells face a host of challenges as they make the transition from working with their host to working against it, such as the need to evade the immune system and to produce more cancer cells, explains Weibo Luo, Ph.D., an instructor in the Institute for Cell Engineering and Department of Biological Chemistry who led the project. All of these efforts require switching on the right genes for the job.

To learn more about how HIF-1 works, the researchers tested a range of human proteins to see whether they would interact with HIF-1. They then sifted through the 200 resulting hits, looking for proteins involved in chemical changes to sections of DNA that determine whether or not the genes they contain are available for use. "In order for HIF-1 to switch
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers discover gender-based differences in Alzheimers disease
2. Researchers find evidence that brain compensates after traumatic injury
3. Researchers find decline in availability and use of key treatment for depression
4. Researchers implicate well-known protein in fibrosis
5. Researchers build synthetic membrane channels out of DNA
6. JTCC researchers play important role in groundbreaking study that may change transplant practices
7. Researchers use computer simulations to find true cost of HIV screenings
8. Sleeping Pill Linked to Hospital Falls, Researchers Say
9. Daycare has many benefits for children, but researchers find mysterious link with overweight
10. Researchers outline effective strategies to prevent teen depression and suicide
11. Researchers report potential new treatment to stop Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Epidermal growth factor receptor (EGFR) mutations found in the ... advanced non-small cell lung cancer (NSCLC) patients correlates well ... , EGFR tyrosine kinase inhibitor (TKI) therapy is approved ... but the standard for determining mutation status is with ... limited or not available. A more abundant and less ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... developed by Dr. Sen and Dr. Samantha Pearson to ... glasses, contacts, and avoid corrective vision surgery by instead ... Shane Michaels, prompting an investigative review. , “There’s ... billions of dollars in revenue each year—it’s because people ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Eagerly embracing ... thriving fertility destination, and now offers the top male ... of infertility specialists. The fertility network of IVFinMexico.com ... commitment to world-class reproductive care, female and male infertility, ... up to the standards so eminently set by company ...
(Date:8/22/2014)... The improved access to antiretroviral drugs ... developing world, has led to the decline in the ... due to AIDS globally. However, despite the fact that ... patients becoming affected by the virus is on the ... all related organisations and stakeholders, by 2015, significant investments ...
(Date:8/22/2014)... A new study of self-awareness by Kessler ... (MS) may be able to improve their self-awareness ... ahead of print on July 2 in ... Nancy D. Chiaravalloti & John DeLuca: Metacognitive knowledge ... doi: 10.3233/NRE-141113). Self-awareness is one,s ability to recognize ...
Breaking Medicine News(10 mins):Health News:High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2
... in Patients Diagnosed with Staphylococcal,HIV, Tuberculosis and ... Testing hospitalized,patients for drug-resistant infections can ... cost of care, according to a new ... Technology Association. The report,describes how diagnostic testing ...
... Whitening Plus Tartar ... Protection, CINCINNATI, March 4 ... do? Protect your,hottest accessory this spring: a white smile that goes beyond beauty. ... a day, every day. Crest is proud to introduce the latest,advancement in smile ...
... ARBOR, Mich. Worried about your cholesterol? You may want ... get some sound advice about how to shape up your ... University of Michigan Health System researchers. , Not only ... be able to avoid having to take cholesterol medication, or ...
... Massachusetts again takes ... top e-Prescribing State Honors, DALLAS, March ... in hosted services for email encryption and,e-prescribing, today celebrates National ... building awareness of improving,patient safety at the local level. The ...
... from one of the first genome-wide association studies (GWAS), ... part by The Michael J. Fox Foundation for Parkinsons ... through the National Human Genome Research Institute (NHGRI) and ... the National Institutes of Health (NIH). NHGRI hopes to ...
... therapy of Prostacyclin, Sildenafil, and Bosentan helped a ... enough to receive a liver transplant. It was ... health. These findings are published in the March ... Wiley & Sons. The article is also available ...
Cached Medicine News:Health News:Hospital Testing for Drug-Resistant Infections Dramatically Lowers Mortality Rates and Costs 2Health News:Step Up Your Smile Routine and Protect Your Teeth in Just Five Minutes a Day 2Health News:Step Up Your Smile Routine and Protect Your Teeth in Just Five Minutes a Day 3Health News:Study shows cholesterol-lowering power of dietitian visits 2Health News:Study shows cholesterol-lowering power of dietitian visits 3Health News:Study shows cholesterol-lowering power of dietitian visits 4Health News:Zix Corporation Celebrates National Patient Safety Awareness Week with Continued Success in e-Prescribing 2Health News:Zix Corporation Celebrates National Patient Safety Awareness Week with Continued Success in e-Prescribing 3Health News:Genome-wide association study on Parkinson's disease finds public home at NIH 2Health News:Genome-wide association study on Parkinson's disease finds public home at NIH 3Health News:Genome-wide association study on Parkinson's disease finds public home at NIH 4Health News:Genome-wide association study on Parkinson's disease finds public home at NIH 5Health News:A combination therapy of 3 vasodilators may treat portopulmonary hypertension 2
(Date:8/22/2014)... 22, 2014 ... has announced the addition of the  "Global ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... instrument for any modern science laboratory as ... materials. It can be broadly classified into ...
(Date:8/22/2014)... Aug. 22, 2014 /CNW/ - On Aug. 20, at ... the Canadian Medical Association (CMA) voted on and approved ... material, including medicinal cannabis. Bedrocan Cannabis Corp., a leading ... the CMA motion. The CMA is quite ... associated with smoking any plant material, including medicinal cannabis. ...
(Date:8/22/2014)... 22, 2014   Zacks Equity Research highlights Epizyme (Nasdaq: ... Day and Panera (Nasdaq: PNRA - Free Report ) as ... analysis on Amicus Therapeutics (Nasdaq: FOLD - Free Report ), ... SHPG - Free Report ). Here is a ... the Day : The biotech bull market is ...
Breaking Medicine Technology:Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: