Navigation Links
Researchers link inflammatory diseases to increased cardiovascular risk

This release is available in French.

Montreal, September 1, 2009 Patients suffering from two serious autoimmune disorders which cause muscular inflammation are at increased risk of developing cardiovascular disease, says a group of Montreal researchers. Dr. Christian A. Pineau and his team at the Research Institute of the McGill University Health Centre (RI-MUHC) have linked muscular inflammation to increased cardiovascular risk for the first time. Their results were published recently in The Journal of Rheumatology.

Polymyositis (PM) and dermatomyositis (DM) are most common in women and seniors, although they can affect people of any age. Both diseases are caused by a hyperactive immune system which attacks healthy tissue, almost as if the body had become allergic to itself. This causes serious inflammation of muscle tissue in the body, leading to weakness, reduced mobility and, in the case of DM, rashes. Muscles in the heart and the lungs may also be affected.

"Inflammation has recently been recognized as a risk factor along with hypertension and cholesterol problems for arterial diseases that can lead to events such as heart attacks," says Dr. Pineau. Nearly one in 5,000 people suffer from PM and DM, approximately 7,000 in Canada and 75,000 across North America.

"Our results indicate that the risk of heart attack is twice as high in these people as in the general population," says Dr. Sasha Bernatsky, a study co-author. "Each year, one out of every 200 people with muscle inflammation, or myositis, succumbs to a stroke and one out of 75 to a heart attack."

The researchers also noted that the immunosuppressive therapies currently used to treat PM and DM may have a preventive effect against heart attacks. "This is an extremely interesting finding for patients who are suffering from PM and DM but who may be hesitant to undergo this type of treatment," adds Dr. Pineau, noting that some patients are concerned about the possible side-effects of immunosuppressive therapies, such as reduced immunity to infection.

"Sometimes patients do not want to undergo immunosuppressive treatment, which can last for years," adds Dr. Bernatsky. "Knowing that it has additional preventive effects may help some people decide to opt for the treatment."

Cardiovascular diseases are the world's leading cause of death, and the researchers hope that their results will provide a clearer picture of the possible benefits and possibilities of immunosuppressive treatment. As a result of their encouraging findings, Dr. Pineau and his team are now turning their attention to possible benefits of immunosuppressive therapy on other health risks associated with inflammatory diseases.


Contact: Julie Robert
McGill University Health Centre

Related medicine news :

1. Researchers Make Insulin-Producing Cells From Adult Skin Cells
2. Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
3. Researchers find high-dose therapy for liver disease not effective
4. Researchers identify new, cancer-causing role for protein
5. Carnegie Mellon Researchers Develop Novel Tool to Rank Death Rates
6. Researchers evaluate resistance training for diabetes prevention
7. Researchers find that employees who are engaged in their work have happier home life
8. U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis
9. UCSF Researchers Identify Two Key Pathways in Adaptive Response
10. Alcohol advertising reaching too many teens on cable TV, researchers say
11. NIH researchers identify key factor that stimulates brain cancer cells to spread
Post Your Comments:
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a ... X. With ProSidebar: Fasion, video editors can easily add an informative sidebar to ... title opener. Utilize presets featuring self-animating drop zones, lines, bars, and text with ...
(Date:11/27/2015)... , ... November 27, 2015 , ... A simply groundbreaking ... is an interesting show that delves into an array of issues that are presently ... could benefit from open dialogue, this show is changing the subjects consumers focus on, ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women on ... organizations in the country. They have overseen financial turnarounds, shown commitment to their ... healthcare industry as a whole through their advocacy and professional efforts. , Becker's ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 --> ... to use SyMRI to find optimal contrast weighting of MRI ... metastases, and has signed a research agreement with SyntheticMR in ... hospital. Using SyMRI, it is possible to generate multiple contrast ... after the patient has left, thus making it possible to ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
Breaking Medicine Technology: