Navigation Links
Researchers link Huntington's disease to overactive immune response in the brain
Date:7/14/2008

The damage to brain tissue seen in Huntington's disease may be caused by an overactive immune response in the bloodstream and the brain, according to new findings from two teams of researchers at the University of Washington in Seattle and University College London. The findings will be published online July 14 in the Journal of Experimental Medicine.

Working separately, the two teams found evidence in both brain cells and the bloodstream suggesting an important link between the immune system's response and Huntington's disease. Together, the findings may help scientists find biological markers for monitoring the disease progression earlier and with more accuracy, and could help them develop new treatments for the disease. Huntington's is a fatal inherited neurodegenerative disorder for which there is currently no effective treatment.

The UW team, lead by Dr. Thomas Moeller, research associate professor of neurology, had previously studied the role of inflammation and immune response in neurodegenerative diseases like Huntington's and ALS, also known as Lou Gehrig's disease. In this study, they found that patients with Huntington's had higher levels of immune-system signaling molecules, called cytokines, in their brain tissue.

The UW researchers then looked at a mouse-based model of the disease, studying the response of microglia, the immune cells of the nervous system. When the microglia were treated with a molecule triggering an immune response, the microglia from Huntington's mice produced much higher levels of cytokines, the immune system molecules. That finding suggests that the protein produced by the Huntington's disease genetic mutation, a protein called huntingtin, is causing the immune cells to be overactive. The researchers think that overly strong immune response may be the mechanism through which the disease causes damage to neurons in the brain.

"When we found increased levels of cytokines in the brains
'/>"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... 3,000 senior industry executives are expected at ... future of the connected car. A very special attraction ... can read a driver’s brain waves. Visitors to its ... by mind alone just by gripping the steering wheel! ... are working on cognitive load, altering music based on ...
(Date:5/26/2015)... CO (PRWEB) May 26, 2015 It ... diverse community foundation in Colorado. On Wednesday, May 13, ... ushered in a new era of community-based giving with ... Titled “Our Future in the Making,” the event celebrated ... The Denver Foundation to mobilize resources for good. , ...
(Date:5/26/2015)... On May 26, 2015, My Positive Perspective ... distributor Dwayne Windfall. At the start of the episode, Deierlein ... some unique characteristics with it, so could you tell people ... saying, “I was reading the newspaper looking for a job ... looking for a person with hustle. I responded to the ...
(Date:5/26/2015)... Allprovide, the all-natural raw pet food company, today ... now available in three Georgia stores: Pooch-n-Paws in Suwannee; ... Dog Company in Kennesaw. , Allprovide is based out ... climate controlled facility. The fresh ingredients come from select ... food is triple-tested for quality. Unlike most pet foods, ...
(Date:5/26/2015)... CIO Review has chosen SIGNiX for its ... Technology Solution Providers. The positioning is based on an evaluation ... applicable across the entire security spectrum of transactions within life ... , “SIGNiX has been on our radar for some time ... Technology space, and we are happy to showcase them this ...
Breaking Medicine News(10 mins):Health News:The World’s Biggest Connected Car Exhibition is Back in Detroit 2Health News:The World’s Biggest Connected Car Exhibition is Back in Detroit 3Health News:Celebrating "Our Future in the Making" 2Health News:Celebrating "Our Future in the Making" 3Health News:My Positive Perspective Broadcasts Episode with Oceans 6 to Discuss Their Role in Helping the Community 2Health News:Allprovide, the All-Natural Pet Food, Available At Georgia Retailers 2Health News:CIO Review Selects SIGNiX as a 20 Most Promising Pharma and Life Sciences Technology Solution Provider in 2015 2Health News:CIO Review Selects SIGNiX as a 20 Most Promising Pharma and Life Sciences Technology Solution Provider in 2015 3
... PALO ALTO, Calif., April 23 Jazz,Pharmaceuticals, Inc. ... Cozadd, the,company,s Executive Chairman, will provide a corporate ... in Key Biscayne, FL,on May 1, 2008 at ... of the presentation may be accessed by visiting ...
... Technology could one day guide individualized therapy for cancer ... research suggests that scientists are close to developing a ... doctors a heads-up about what kind of treatment is ... into an emerging trend of individualized treatment for patients ...
... Inc. is pleased,to announce Corso Rehabilitation and Physical ... York State to offer the innovative and,non-surgical SpineSix ... pain,patients. Owned and operated by Gary Corso, MS, ... and Physical Therapy Associates provides,outstanding individualized care and ...
... Cream and, Limited-edition CD at Participating Giant Stores on Saturday, May ... ... April 23 ,Everyone,s a winner when you stop into participating Giant stores,throughout ... Triple Winner Game(R) Scoop Day event., This year, EDY,S Grand Ice ...
... 18% to $1.09; ... year, FRANKLIN LAKES, N.J., April 23 BD ... record quarterly revenues,of $1.747 billion for the second fiscal ... percent over the prior year period. This,quarter,s revenue growth ...
... Hurdles To Government Oversight & Gaining ... ... improved,governance structure, the benefits of nanotechnology may be difficult to,fully realize ... director of the Project on Emerging,Nanotechnologies (PEN). Rejeski testifies on Thursday, ...
Cached Medicine News:Health News:Scan Detects Oxygen Levels in Tumors 2Health News:The Future of Spine Care Has Just Gotten Better With the Use of SpineSix BioMotion Spinal System(TM) 2Health News:EDY'S(R) SLOW CHURNED(R) and Giant Food Markets Announce Scoop Day With Sweet Deals to Support the Fight Against Childhood Cancer 2Health News:BD Announces Results for Second Fiscal Quarter 2Health News:BD Announces Results for Second Fiscal Quarter 3Health News:BD Announces Results for Second Fiscal Quarter 4Health News:BD Announces Results for Second Fiscal Quarter 5Health News:BD Announces Results for Second Fiscal Quarter 6Health News:BD Announces Results for Second Fiscal Quarter 7Health News:BD Announces Results for Second Fiscal Quarter 8Health News:BD Announces Results for Second Fiscal Quarter 9Health News:BD Announces Results for Second Fiscal Quarter 10Health News:BD Announces Results for Second Fiscal Quarter 11Health News:BD Announces Results for Second Fiscal Quarter 12Health News:BD Announces Results for Second Fiscal Quarter 13Health News:BD Announces Results for Second Fiscal Quarter 14Health News:BD Announces Results for Second Fiscal Quarter 15Health News:Improved Governance Needed To Realize Nanotech's Benefits 2
(Date:5/26/2015)... DIEGO , May 26, 2015 ... a clinical-stage biopharmaceutical company leveraging its molecular adhesion ... therapies for sickle cell disease, heart failure, and ... an open-label, multicenter Phase 3 extension study of ... as "EPIC-E."  The study will enroll patients who ...
(Date:5/26/2015)... , May 26, 2015  Accuray Incorporated (Nasdaq: ... is scheduled to present at the Jefferies 2015 Healthcare ... Wednesday, June 3, 2015 at 2:30pm ET.   ... available on the Investor Relations page of the Company,s ... the presentation will begin approximately one hour after the ...
(Date:5/26/2015)... 26, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... , president and chief executive officer, is scheduled ... will provide an update on Egalet,s marketed product ... Spray, approved product OXAYDO ™ (oxycodone HCI, ...
Breaking Medicine Technology:Mast Therapeutics Announces Initiation Of EPIC-E Study 2Mast Therapeutics Announces Initiation Of EPIC-E Study 3Mast Therapeutics Announces Initiation Of EPIC-E Study 4Mast Therapeutics Announces Initiation Of EPIC-E Study 5Egalet to Present at Upcoming Conferences in June 2Egalet to Present at Upcoming Conferences in June 3
... 2, 2011 Aoxing Pharmaceutical (NYSE Amex: ... company focusing on research, development, manufacturing and distribution ... operating subsidiary in China, Hebei Aoxing Pharmaceutical Group ... State Intellectual Property Office of The People,s Republic ...
... TARRYTOWN, N.Y., May 2, 2011 Regeneron Pharmaceuticals, Inc. (Nasdaq: ... of America Merrill Lynch 2011 Health Care Conference on Tuesday, ... Eastern Time).  The session may be accessed through the Company,s ...  An archived version of the presentation will be available after ...
Cached Medicine Technology:Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 2Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 3
... The VitalView™ Central Station is ... Criticare bedside monitors for vital signs ... displayed in real time, with simultaneous ... ECG events, graphical and tabular trends ...
... These specialty Eraser instruments have ... surgeon with the right tool for ... introduced a series of 25 gauge ... provide discrete treatment of target tissues ...
... Chart Manager provides powerful workflow tools such ... integrated transcription services, and customized flow sheets ... eliminates the need for paper charts. ... a paperless office now and can easily ...
... The Cerner PowerChart Electronic Medical ... solutions designed to create an enterprise-wide, ... (EMR). PowerChart streamlines the workflow process ... access to the functions that support ...
Medicine Products: