Navigation Links
Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
Date:12/10/2007

PHILADELPHIA - A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.

The Penn team, led by Christopher Hunter, chair of the Department of Pathobiology at Penn Vet, has identified the pathways that lead to the production of the signaling protein, or cytokine, Interleukin 10 (IL-10) which plays an important role in regulating the balance between the protective white blood, or T, cell response and one that is pathological and out of control.

While IL-10 has long been recognized as a major anti-inflammatory factor, the events that lead to its production have been poorly understood. According to the researchers findings, messenger proteins Interleukin 27, or a combination of Interleukin 6 and another type of messenger molecule called transforming growth factor beta, induce production of IL-10. These results suggest that modulating these messenger molecules could increase IL-10 concentrations that temper overactive immune responses.

This information sheds new light on the immune-system response and may provide directed means to intervene in severe autoimmune diseases such as colitis, multiple sclerosis and arthritis.

The deeper we delve into the role of cytokines in the immune system response, the more we realize that they are part of an elaborately balanced system kept in check by the conflicting regulatory functions of the cytokines themselves, Hunter said. When combined with the work from our colleagues at Schering Plough, Harvard and Jefferson University, these studies provide new insights into the pathways that can be used to temper autoimmune inflammation.

Although there are many sources of IL-10 in the body, the details of how it is synthesized were poorly understood. Hunters team determined that the process begins with c
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... Mansfield, MA (PRWEB) May 25, 2013 Imagine ... long -- the energy loss, hot air and wasted energy! ... whole house fan, a fireplace or clothes dryer, that may ... , Drafts from these often overlooked holes waste energy in ... source of heating and cooling loss in the home. , ...
(Date:5/25/2013)... May 25, 2013 Life science and ... used to detect and create a new substance with ... and are also known as biotechnology reagents. Such reagents ... and education. , This market is driven by factors ... the field of therapeutics, growth in research and rapid ...
(Date:5/25/2013)... -- Animals make great companions for senior citizens, but elderly ... are far more likely to crash than those who never ... study included 2,000 licensed drivers aged 70 and older. The ... they drove with their pet in the car. Among ... was twice as high as among those who never drove ...
(Date:5/25/2013)... Sun City Center, FL (PRWEB) May 25, 2013 ... years, is one of many of the NALA’s businesses throughout ... Owner, Craig Amshel chose to participate in the nationwide event ... served as a Lieutenant Colonel in the Army. He said, ... work in the community I serve, but I live here ...
(Date:5/25/2013)... 25, 2013 On May 25, Voices ... research and advocacy, comments on a new study by ... incorporating cold atmospheric plasma into brain cancer treatment may ... to a Science Daily article, physicists from ... and physicians demonstrated the “synergistic effect of cold atmospheric ...
Breaking Medicine News(10 mins):Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 2Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 3Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 4Health News:Life Sciences And Analytical Reagents Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research 2Health News:Life Sciences And Analytical Reagents Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research 3Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:Dr. Craig Amshel of Absolute Surgical Specialists Offering Bowel Prep During the Shop Local for a Cause Event 2Health News:Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells 2
... signal is thought to worsen the symptoms of MS, say ... holds promise in the development of novel strategies// to treat ... not yet in place. ,The study has ... is in charge of managing the signal, might be the ...
... Experts on allergy have advised that avoiding milk and dairy ... the risk of food allergies//. ,Dr. Alessandro Fiocchi ... colleagues from the Adverse Reactions to Foods Committee of the ... written in their report that there are no evidence-based guidelines ...
... to separate four-year-old conjoined twin girls, surgeons in the US ... separate their liver. ,The operation in Salt Lake City ... who share a kidney. Kendra and Maliyah Herrin are joined ... ,If the surgery at Primary Children's Hospital is successful, ...
... The National AIDS Control Programme, in its next stage, will ... level to combat the disease more effectively//. ,National ... said that after the completion of the NACP-II in March ... will be cleared by November. ,"The campaign is ...
... thousands displaced by the Israel-Hezbollah conflict is getting worse as ... amid fears of epidemic outbreaks. ,"We are now faced ... increasing, we are soon moving towards a de-facto blockade of ... for Refugees office. ,Israel's bombing of all the ...
... urging Chief Minister V.S. Achuthanandan to immediately ban the sale ... tender coconut may finally get its due. ,Despite the ... state, sales have been low. Now, with the controversy over ... Coca-Cola creating a furore again, the government is going to ...
Cached Medicine News:Health News:Breast Milk Safest For Child Till Six Months of Age 2Health News:AIDS Control Programme to Focus on District Level 2Health News:Lebanon Fears of Epidemics as the Crisis Deepens 2
(Date:5/23/2013)... May 23, 2013  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... named the 2013 Life Science Firm of the Year by ... Vanda was honored at the TCM,s 25 th Annual ... Maryland.  The Tech Awards Celebration recognizes the leaders and innovators ... Maryland and the surrounding regions. ...
(Date:5/23/2013)... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Executive Officer of Neurocrine Biosciences, will be presenting at the ... in Boston.   The live presentation takes place ... 8:20 a.m. Pacific Time.  The presentation will be webcast and ... . If you are unable to attend ...
(Date:5/23/2013)... , May 23, 2013  Haemonetics Corporation (NYSE: ... , CFO & EVP-Business Development, will present at The ... in Boston, MA on May 29, ... http://photos.prnewswire.com/prnh/20120206/NE47232LOGO ) The public may access Mr. ... About Haemonetics Haemonetics (NYSE: ...
Breaking Medicine Technology:Vanda Pharmaceuticals Named the 2013 Life Science Firm of the Year by the Tech Council of Maryland 2
... , April 23, 2010 , , , ... A Migraine For Pharma Forecasters , , , ... up,s and down,s, with new markets,and products proving more complex and requiring sophisticated approaches to,forecast these areas. ... Dealing with uncertainties is no easy task. With a number ...
... TOKYO , April 23 Astellas Pharma Inc. (TSE: ... $52 per share for all of the currently outstanding shares ... Inc. (Nasdaq: OSIP ) to 5:00 p.m. New ... further extended.  The tender offer was previously set to expire at 12:00 ...
Cached Medicine Technology:MarketsandMarkets Partners With Eyeforpharma For The Pharma Forecasting Excellence Europe 2010 Summit 2MarketsandMarkets Partners With Eyeforpharma For The Pharma Forecasting Excellence Europe 2010 Summit 3Expiration Date of OSI Offer Extended to May 17, 2010 2Expiration Date of OSI Offer Extended to May 17, 2010 3Expiration Date of OSI Offer Extended to May 17, 2010 4
Primary and Posterior Stabilized Components....
... knee prosthesis stems from many years of ... manufacturing technologies have been used in order ... as a favorable pressure distribution pattern on ... to a minimum. The inherent design of ...
... The Natural Knee design ... a proprietary CSTi porous coating ... active patients, a unique bone ... deepened trochlear groove to maximize ...
Advance Posterior Stabilized Total Knee systems improves patellofemoral kinematics, reduces wear rate potential, increases resistance to posterior tibial dislocation, achieves at least 120o flexion i...
Medicine Products: