Navigation Links
Researchers investigate ways to detect lupus-associated kidney disease
Date:11/12/2007

DALLAS Nov. 13, 2007 High urinary levels of certain molecules might have the potential to serve as biomarkers for a potentially life-shortening kidney ailment caused by the autoimmune disease lupus, UT Southwestern Medical Center researchers have found.

Our studies suggest a quartet of molecules may have potential diagnostic significance, said Dr. Chandra Mohan, professor of internal medicine and senior author of a study available online at the Journal of Immunology. Given that early intervention in lupus nephritis is associated with better treatment outcome, it is imperative that disease activity in the kidney be diagnosed as early as possible.

Lupus is a chronic autoimmune disease in which the immune system attacks the bodys cells and tissues. In a normal immune system, foreign intruders are recognized by special immune cells that produce antibodies. In patients with lupus, however, the antibodies created start to attack the body itself. When the antibodies attack the kidneys, nephritis occurs, often shortening a patients life expectancy.

Dr. Mohan and colleagues screened urine from mice with lupus nephritis for the presence of four compounds VCAM-1, P-selection, TNFR-1 and CXCL 16. Previous research had suggested that these molecules are elevated in animal models of antibody-mediated nephritis. Dr. Mohan and his research team determined that the mice harbored increased levels of all four molecules in the urine, particularly at the peak of their lupus-associated kidney disease.

The most reliable method now available for monitoring renal disease in lupus patients is to measure the level of protein excreted in urine. As part of their study, the researchers also tested the urine of lupus patients and found that they not only had high protein levels in their urine, but also elevated levels of all four compounds.

It would be very beneficial to detect the presence of nephritis early in order to administer therapies to stop the immune system from destroying the kidney, said Dr. Mohan. There is an urgent need for a biomarker that one could potentially use to predict the onset of nephritis. That is what were trying to discover with this research.

Dr. Mohan said further studies are in progress to ascertain if checking these molecule levels might be more effective than monitoring protein levels to predict kidney disease in lupus patients.

The ability to detect these molecules in urine could potentially have tremendous impact on clinical diagnostics. Not only is urine a convenient body fluid to procure; in some clinical settings it may be the only fluid available, he said.

Some of the compounds might play a critical role in deciphering potential drug targets for therapeutic intervention. Although more research is needed, blocking one or more of these molecules might offer relief to patients suffering from lupus nephritis, Dr. Mohan said.

In humans, lupus can cause life-threatening damage not only to the kidneys, but also to the lungs, heart, central nervous system, joints, blood vessels and skin. It can be associated with severe fatigue, joint pain, skin rashes, hair loss and neurological problems. Although treatable symptomatically, there is currently no cure for the disease, which affects up to 1 million people in the U.S.


'/>"/>

Contact: Erin Prather Stafford
erin.pratherstafford@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center  
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers investigate ways to detect lupus-associated kidney disease
(Date:6/23/2017)... Beach, CA (PRWEB) , ... June 23, 2017 , ... ... has earned its ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, ... in the top 1% of all charities reviewed by Charity Navigator and earns ANRF ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... practicing in Newburgh, New York, has recently begun offering three new minimally invasive ... the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to bring ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... Everybody has ... it while others prefer to read it, and some people don't like it at ... pornography. Here's what they found: , Erotic literature can give readers a taste of ...
(Date:6/23/2017)... ... 2017 , ... The Aesthetic Channel has recently highlighted Dr. Ben Talei’s unique ... a proprietary technique that he calls the AuraLyft Facelift. The AuraLyft does ... patients can expect to look refreshed, rejuvenated, and revitalized. , Dr. Talei’s unique ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... Friday, July 28, 2017, beginning at 7:30 a.m. (CDT) / ... information: To participate in the conference call, dial (877) 304-8969 ... at least 10 minutes prior to the start to allow ... Webcast: A simultaneous webcast of ...
(Date:6/16/2017)... , June 16, 2017  Exactly 50 years ago ... off what later became known as the San Francisco "Summer ... ) is unveiling two radical innovations in strategic market research ... This announcement marks the beginning of Northern Light,s "Summer of ... ...
(Date:6/14/2017)... WINSTON-SALEM, N.C. , June 14, 2017  In ... the Creative Startups pitch competition and came ... virtual reality platform is described by Forbes as "entering ... the American Medical Association as teaching "empathy to medical ... success, the startup was recently named a finalist for ...
Breaking Medicine Technology: