Navigation Links
Researchers inject nanofiber spheres carrying cells into wounds to grow tissue
Date:4/17/2011

ANN ARBOR, Mich.---For the first time, scientists have made star-shaped, biodegradable polymers that can self-assemble into hollow, nanofiber spheres, and when the spheres are injected with cells into wounds, these spheres biodegrade, but the cells live on to form new tissue.

Developing this nanofiber sphere as a cell carrier that simulates the natural growing environment of the cell is a very significant advance in tissue repair, says Peter Ma, professor at the University of Michigan School of Dentistry and lead author of a paper about the research scheduled for advanced online publication in Nature Materials. Co-authors are Xiaohua Liu and Xiaobing Jin.

Repairing tissue is very difficult and success is extremely limited by a shortage of donor tissue, says Ma, who also has an appointment at the U-M College of Engineering. The procedure gives hope to people with certain types of cartilage injuries for which there aren't good treatments now. It also provides a better alternative to ACI, which is a clinical method of treating cartilage injuries where the patient's own cells are directly injected into the patient's body. The quality of the tissue repair by the ACI technique isn't good because the cells are injected loosely and are not supported by a carrier that simulates the natural environment for the cells, Ma says.

To repair complex or oddly shaped tissue defects, an injectable cell carrier is desirable to achieve accurate fit and to minimize surgery, he says. Ma's lab has been working on a biomimetic strategy to design a cell matrix---a system that copies biology and supports the cells as they grow and form tissue---using biodegradable nanofibers.

Ma says the nanofibrous hollow microspheres are highly porous, which allows nutrients to enter easily, and they mimic the functions of cellular matrix in the body. Additionally, the nanofibers in these hollow microspheres do not generate much degradation byproducts that could hurt the cells, he says.

The nanofibrous hollow spheres are combined with cells and then injected into the wound. When the nanofiber spheres, which are slightly bigger than the cells they carry, degrade at the wound site, the cells they are carrying have already gotten a good start growing because the nanofiber spheres provide an environment in which the cells naturally thrive.

This approach has been more successful than the traditional cell matrix currently used in tissue growth, he says. Until now, there has been no way to make such a matrix injectable so it's not been used to deliver cells to complex-shaped wounds.

During testing, the nanofiber repair group grew as much as three to four times more tissue than the control group, Ma says. The next step is to see how the new cell carrier works in larger animals and eventually in people to repair cartilage and other tissue types.


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-764-1552
University of Michigan
Source:Eurekalert

Related medicine news :

1. Wistar researchers follow a path to a potential therapy for NF2, a rare tumor disorder
2. Whales Not Just Singing the Same Old Song, Researchers Say
3. Boston University researchers find most substance-dependent individuals report poor oral health
4. University of Granada researchers make the first bioartificial organ in Spain
5. Queens researchers pioneer needle-free test for premature babies
6. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
7. Researchers find anatomic differences after robotic-assisted radical prostatectomy
8. Researchers present new findings on cancer and gene therapy
9. Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
10. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
11. UPCI, Pitt researchers present findings of cancer studies at AACR 102nd Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... ... May 21, 2017 , ... ... together a cross-disciplinary group of scholars, policymakers, and activists wanting to address equity ... Equity is the third book from a recent series of from this ...
(Date:5/21/2017)... ... May 21, 2017 , ... Dental visits are ... months since you've seen a dentist, it's time for a dental checkup. The ... once per year. , Dental checkups are a relatively easy procedure that involves ...
(Date:5/19/2017)... City, Mo (PRWEB) , ... May 19, 2017 , ... ... Saturday, May 20, his name will already appear on two major research studies that ... has been working with Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... class of Beckman Young Investigators: , Victor Acosta, Ph.D. - University of New ... Dan Fu, Ph.D. - University of Washington, Erik Grumstrup, Ph.D. - Montana Stata ...
(Date:5/19/2017)... ... May 18, 2017 , ... CloSYS products which are marketed ... while extremely helpful for mouth and gum health, which is linked to one’s overall ... customers learned quickly of the powerful ways in which CloSYS products immediately helped eliminate ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
(Date:5/12/2017)... and Canada joint tech company Laughing Face has ... detergent, and features a powerful disinfection process. The company ... washes and sanitizes women,s panties or babies, cloth diapers in 25 ... ... an external water inlet. ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
Breaking Medicine Technology: