Navigation Links
Researchers identify variations in four genes associated with an increased risk of colorectal cancer
Date:2/20/2013

SEATTLE An international research team co-led by cancer prevention researcher Ulrike "Riki" Peters, Ph.D., M.P.H., and biostatistician Hsu Li, Ph.D., at Fred Hutchinson Cancer Research Center has identified variations in four genes that are linked to an increased risk of colorectal cancer. Peters and colleagues from 40 institutes throughout the world published their findings online ahead of the April print issue of Gastroenterology.

Peters and colleagues for the past four years have been studying the genes linked to colorectal cancer through the Genetics and Epidemiology of Colorectal Cancer Consortium, a collaboration involving researchers from North America, Australia and Europe who have pooled data from approximately 40,000 study participants, about half of whom have colorectal cancer. Fred Hutch houses GECCO's coordinating center and Peters is its principal investigator.

The genomewide-association study was conducted in two phases. The first involved rapidly scanning complete sets of blood DNA from 12,696 people with colorectal cancer or a precancerous condition called adenoma. This data was then compared to the same set of variants from 15,113 healthy controls of European descent.

Of 2.7 million genetic variants identified, the 10 most statistically significant mutations associated with colorectal cancer were then further analyzed in a follow-up genomewide-association study of 3,056 colorectal cancers or adenomas and colon-tissue samples from 6,658 healthy controls of European and Asian descent.

The research team uncovered mutations in the following genes all genetic variants that previously had not been associated with colorectal cancer:

  • NABP a gene involved in DNA repair
  • LAMC1 the second gene in the laminin gene family found to be associated with colorectal cancer
  • CCND2 a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development
  • TBX3 a gene transcription factor that targets a known colorectal cancer pathway

If a person carries one or two copies of any of these genetic variants, their risk of colorectal cancer is increased by 10 percent to 40 percent compared to a person who does not harbor such DNA genetic variants, Peters said.

"These findings could potentially lead to new drug targets and, in combination with previously identified genetic and environmental risk factors, identify subgroups of the population that can benefit most from colorectal-cancer screening and could be targeted for early or more frequent endoscopy, a very effective screening tool for colorectal cancer," said Peters, a member of the Public Health Sciences Division at Fred Hutch.


'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... ... Radio with Hypnotherapist, Mary O'Maley. What is hypnosis and hypnotherapy and why ... smoking, weight control), pain relief (chronic and acute), birthing processes and medical procedures, ...
(Date:4/30/2016)... ... , ... well is a challenge for all of us, but there are things we can do to ... “Research is showing more and more that there are simple, yet important steps that can ... age.” Top priorities Dr. Kohli’s recommends for her patients include;, , exercise ...
(Date:4/29/2016)... ... April 29, 2016 , ... Since launching its annual ... foundation serving the footwear industry, has broken all previous participation records in its ... across 23 states during the months of April and May, the 2016 Footwear ...
(Date:4/29/2016)... Palm Springs, California (PRWEB) , ... April 29, ... ... It lies at the heart of our nation’s productivity, stability, even security. Most ... profitability for their organizations. , Then why are American workers so unhappy? , ...
(Date:4/29/2016)... ... April 29, 2016 , ... A new ... with severe congenital diaphragmatic hernia have better survival rates if surgery is performed ... (CDH)—a condition where the diaphragm fails to form completely, letting abdominal organs into ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... India , April 29, 2016 ... Pipeline Review, H1 2016" market research report that ... complete with comparative analysis at various stages, therapeutics ... route of administration (RoA) and molecule type, along ... releases. It also reviews key players involved in ...
(Date:4/28/2016)... 2016   Click here for supplemental information ... DPLO), the nation,s largest independent specialty pharmacy, announced ... to acquire Valley Campus Pharmacy, Inc., doing business ... specialty pharmacy that provides individualized patient care, based ... In 2015, TNH generated approximately $400 million in ...
(Date:4/28/2016)... 28, 2016  The blood testing market in ... to Kalorama Information and The Freedonia Group in a ... acid testing.  The healthcare research firm said that ... blood collection stations and in improving testing at the ... report, Blood Testing Market in China ...
Breaking Medicine Technology: