Navigation Links
Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
Date:2/20/2013

SEATTLE An international research team co-led by cancer prevention researcher Ulrike "Riki" Peters, Ph.D., M.P.H., and biostatistician Hsu Li, Ph.D., at Fred Hutchinson Cancer Research Center has identified variations in four genes that are linked to an increased risk of colorectal cancer. Peters and colleagues from 40 institutes throughout the world published their findings online ahead of the April print issue of Gastroenterology.

Peters and colleagues for the past four years have been studying the genes linked to colorectal cancer through the Genetics and Epidemiology of Colorectal Cancer Consortium, a collaboration involving researchers from North America, Australia and Europe who have pooled data from approximately 40,000 study participants, about half of whom have colorectal cancer. Fred Hutch houses GECCO's coordinating center and Peters is its principal investigator.

The genomewide-association study was conducted in two phases. The first involved rapidly scanning complete sets of blood DNA from 12,696 people with colorectal cancer or a precancerous condition called adenoma. This data was then compared to the same set of variants from 15,113 healthy controls of European descent.

Of 2.7 million genetic variants identified, the 10 most statistically significant mutations associated with colorectal cancer were then further analyzed in a follow-up genomewide-association study of 3,056 colorectal cancers or adenomas and colon-tissue samples from 6,658 healthy controls of European and Asian descent.

The research team uncovered mutations in the following genes all genetic variants that previously had not been associated with colorectal cancer:

  • NABP a gene involved in DNA repair
  • LAMC1 the second gene in the laminin gene family found to be associated with colorectal cancer
  • CCND2 a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development
  • TBX3 a gene transcription factor that targets a known colorectal cancer pathway

If a person carries one or two copies of any of these genetic variants, their risk of colorectal cancer is increased by 10 percent to 40 percent compared to a person who does not harbor such DNA genetic variants, Peters said.

"These findings could potentially lead to new drug targets and, in combination with previously identified genetic and environmental risk factors, identify subgroups of the population that can benefit most from colorectal-cancer screening and could be targeted for early or more frequent endoscopy, a very effective screening tool for colorectal cancer," said Peters, a member of the Public Health Sciences Division at Fred Hutch.


'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
2. NIH-funded researchers begin trial of Shigella vaccine candidates
3. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
4. Researchers guardians of trust in biobank research
5. Researchers Detect an Anti-Autism Advantage in Females
6. Einstein researchers present on imaging advances
7. Researchers at St. Michaels Hospital test tool for screening cancer patients for malnutrition
8. Researchers uncover new findings on genetic risks of Behçets disease
9. Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer
10. Researchers discover breakthrough in ovarian cancer
11. UNC researchers discover gene that suppresses herpesviruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... Goodcents Deli ... , The restaurant is located at 4210 SW 21st St. Topeka, Kan. 66604 (near ... owner of Graham Restaurant Group who owns three other locations in the Topeka and ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... MD ... Florida. This is MD Now’s 28th facility overall and marks the urgent care center's ... located one mile North of The Falls shopping mall. The new clinic offers a ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... planning, and related services to families and business owners in and around Lackawanna ... to benefit senior citizens in the area. , Meals on Wheels of NEPA ...
(Date:6/22/2017)... ... ... Branches, Inc. has been partnering with The Miami Foundation for over 9 years, ... on providing opportunity to low-income families and breaking the cycle of generational poverty. , ... support its , Climb to College & Career initiative which focuses on postsecondary success. ...
(Date:6/22/2017)... ... June 23, 2017 , ... Despite its pervasiveness, many ... reviews available that integrate basic science with clinical practice. Now, however, a timely review ... providing clinicians with insight into the etiology of NeuP and educating preclinical scientists on ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... , June 7, 2017 Endo International plc ... 7, 2017, the Hon. Joseph R. Goodwin , ... West Virginia , entered a case ... Pelvic Repair System Products Liability Litigation (the "MDL") that ... cases to provide expert disclosures on specific causation within ...
(Date:6/5/2017)... Neb. , June 5, 2017 ... in the United States . ... helps a fallen person up to an almost-standing ... easily assembled and operated by one assistant and does ... It is simple enough that a child can operate ...
(Date:5/30/2017)... , May 30, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... data solutions, today announced that it will be presenting at the ... 8:00 AM PT. Erez Raphael , CEO, of DarioHealth will ... conference will be held on June 6th & 7th, 2017 at ... in the small / micro-cap space. ...
Breaking Medicine Technology: