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Researchers identify unusual molecular switch for common form of advanced breast cancer
Date:11/8/2007

n the majority of human large advanced breast tumors. Using breast cancer cells and animal tumor models, the researchers observed that elevated levels of 4E-BP1 trigger hypoxia inhibition of conventional protein synthesis in tumor cells, and with eIF4G, then increases the selective translation of specific mRNAs that promote tumor survival and angiogenesis, thereby functioning as a hypoxia controlled switch for tumor growth and survival.

These results present a entirely new understanding of the control of breast cancer angiogenesis that places the regulation of protein synthesis as a key event in malignant breast cancer. This research opens new avenues for the development of targeted approaches in the treatment of one of the most common lethal forms of breast cancer worldwide, says Dr. Formenti. The work was funded by the Breast Cancer Research Foundation and the Department of Defense Breast Cancer Research Program.


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Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
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