Navigation Links
Researchers identify traffic cop for meiosis--with implications for fertility and birth defects
Date:10/1/2013

Researchers at New York University and the Whitehead Institute for Biomedical Research have identified the mechanism that plays "traffic cop" in meiosisthe process of cell division required in reproduction. Their findings, which appear in the journal eLife, shed new light on fertility and may lead to greater understanding of the factors that lead to birth defects.

"We have isolated a checkpoint that is necessary for a genome's viability and for normal development," said Andreas Hochwagen, an assistant professor in NYU's Department of Biology, who co-authored the paper with Hannah Blitzblau, a researcher at the Whitehead Institute for Biomedical Research. "Without this restraining mechanism, chromosomes can end up irreversibly broken during meiosis."

The paper may be downloaded here: http://dx.doi.org/10.7554/eLife.00844.

Most cells in an organism contain two sets of chromosomes, one inherited from the mother and the other from the father. However, sexual reproduction relies on the production of gametes eggs and sperm that contain only one set of chromosomes. These are produced through a specialized form of cell divisionmeiosis.

In this process, maternal and paternal versions of each chromosome pair up and swap sections of their DNA through a process known as homologous recombinationa "reshuffling" that gives rise to chromosomes with new combinations of maternal and paternal genes. This is followed by cell division.

However, in order for normal development to occur, chromosomes must be replicated prior to their reshuffling. The disruption of this process jeopardizes reproduction and can spur a range of birth defects, notably Down syndrome.

Blitzblau and Hochwagen sought to determine what coordinates these processes to ensure they occur in proper order. Doing so would offer insights into how deviations from normal functionality could affect fertility and result in birth defects.

To do so, they examined budding yeast--a model organism in cell biology because its chromosome replication and regulation are similar to that of humans.

Through a series of manipulations, in which the researchers inhibited the activity of individual proteins, they found two enzymes that were necessary for meiosis: Mec1, which is similar to ATR, known to suppress tumors in humans, and DDK, which is a vital coordinator of chromosome reshuffling.

Specifically, they found that Mec1 senses when chromosomes are being replicated and transmits a molecular "wait" signal to DDK. In this way, Mec1 acts like a traffic cop that allows chromosome replication to finish without interruption, before giving DDK the ok to begin the reshuffling.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related medicine news :

1. Researchers find that drinking fluoridated water gives no additional risks for hip fractures
2. Mayo Clinic researchers apply regenerative medicine to battlefield injuries
3. Dartmouth researchers receive $5.9 million grant from NIH for lung research
4. Voices Against Brain Cancer Discusses Recent Finding By Johns Hopkins Researchers Concerning Brain Tumor Treatments
5. Nearly $4 million awarded to GW School of Public Health and Health Services researchers
6. Penn Medicine researchers harness the immune system to fight pancreatic cancer
7. Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on New Report Detailing Researchers’ Ties to Intuitive Surgical, Inc.
8. Researchers identify risk-factors for addictive video-game use among adults
9. Johns Hopkins researchers erase human brain tumor cells in mice
10. Mayo Clinic researchers identify biomarker for smokers lung cancer
11. Researchers Identify Genes Tied to Breast Cancer that Spreads to the Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... (PRWEB) , ... April 28, ... ... Standards Consortium (CDISC) announces today the open availability of a new CDISC ... and catalogs for registering clinical trials. This innovative standard will make it ...
(Date:4/28/2016)... ... April 28, 2016 , ... In many parts of ... determinant of childhood mortality. This is particularly true in underdeveloped parts of Africa where ... University of New England’s campus in Tangier, Morocco, will examine this global health issue ...
(Date:4/28/2016)... ... April 28, 2016 , ... One way to ignore solid evidence is to ... But we toss the baby out with the bathwater when we ignore all studies ... higher-quality studies and otherwise making better use of education policy research. , “When readers ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... of miniature microphones and headsets announced today that the US Patent Office has ... in-earphones into a structure. This innovative design creates a lightweight and modular audio ...
(Date:4/28/2016)... ... April 28, 2016 , ... SyncDog, Inc. , ... leading secure mobility workstation suite, SentinelSecure™, at MobileIron’s 6th annual Mobile First Conference ... will be MobileIron’s 6th Mobile First Conference and will feature immersive training, collaboration, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... H1 2016" is a report that provides an ... strengthen R&D pipelines by identifying new targets and ... Company Profiles discussed in this H1 2016 ... Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., Ablynx ...
(Date:4/27/2016)... , April 27, 2016 ... accelerator (MR-linac) platform will be the focal point of ... of the European Society for Radiotherapy & Oncology, taking ... MR-linac integrates a state-of-the-art radiotherapy system and a high-field ... to clearly see the patient,s anatomy in real time. ...
(Date:4/27/2016)... Massachusetts , April 27, 2016 ... that Jeff Poulton , Chief Financial Officer, will present ... Boston, MA on Wednesday, May 04, ... audio webcast will be available on the Presentations and Webcasts ... a replay of the webcast will be available on this ...
Breaking Medicine Technology: