Navigation Links
Researchers identify toehold for HIV's assault on brain
Date:11/14/2008

his a doctor with whom Gelbard had trained became ill and died of AIDS in less than two years. His friend's struggle, and the severity of his neurological symptoms, touched Gelbard. Gradually, with the support of mentors, Gelbard came to focus on the neurological effects of HIV. He now leads a group of researchers funded by the National Institute of Mental Health that is trying to identify or create the first treatment for the neurological effects of HIV, known collectively as neuroAIDS or HIV dementia.

Scientists have known that Tat, which helps HIV operate, replicate, and infect cells, is at the forefront of HIV's attack on the brain, bringing about severe inflammation. Immune cells within the brain go into overdrive, churning out substances that attract more immune cells, and white blood cells from the body flood in and join the fray, all clumping together to form destructive entities known as multinucleated giant cells.

"Suddenly the brain environment turns from nurturing to toxic, and the brain has to work much harder to send messages. Cells are on overdrive, spending a lot more energy to do the same things they used to do easily," said Gelbard, who is director of the Center for Neural Development and Disease at Rochester.

Other changes occur throughout the brain as well. Neurons that normally reach throughout the brain by forming networks of far-reaching, delicate extensions crucial for cell communication become damaged. Instead of sprouting healthy dendrites projections that resemble tiny trees neurons in the brain of an HIV patient have had parts of their dendrites abruptly torn off, in a process known as "synaptic pruning." The dendrites begin to look like a patch of severely damaged trees after a bad ice storm.

Such damage occurs in parts of the brain crucial for thinking, decision-making, and movement and memory. That accounts for symptoms like difficulties concentrating, forgetfulness, poor coordination, confusio
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
2. Researchers Use New Method to Control Bleeding in Hemophilia
3. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
4. Protein can nurture or devastate brain cells, depending on its friends, researchers find
5. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
6. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
7. Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting
8. USC researchers identify key mechanism that regulates the development of stem cells into neurons
9. Cornell researchers study showing evidence of a major environmental trigger for autism
10. Maastricht University researchers produce neural fingerprint of speech recognition
11. Researchers aim to over-stress already taxed mantle cell lymphoma cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... to scans performed in 2007 , , MONDAY, Dec. 14 ... to far more radiation than previously thought and in doses ... two new studies claim. , Based on the findings, reported ... Internal Medicine , the study authors, joined by Archives ... to limit radiation exposure to patients. , "CT has become ...
(Date:12/14/2009)... HILL -- Type 2 diabetes and obesity are linked ... published studies suggested that insulin glargine (a synthetic insulin ... associated with a higher risk of certain cancers than ... these studies were unable to control for important factors ... , On the other hand, a large randomized ...
(Date:12/14/2009)... lower rates for meth and smoking, but concerns ... (HealthDay News) -- Fewer teenagers are using methamphetamine, ... abuse of prescription drugs remains high, U.S. health ... newer drugs, such as the hallucinogenic salvia leaf ... for treatment of attention-deficit hyperactivity disorder (ADHD), appear ...
(Date:12/14/2009)... Congress to Ensure Health Workforce Recommendations are ... -- Congressional leaders must ensure that health ... with sufficient authority to ensure implementation of ... according to Dr. Steven A Wartman, president ... Health Centers (AAHC). "With each step ...
(Date:12/14/2009)... Following is a statement of Matthew L. Myers, ... http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) ,, The 2009 Monitoring the Future ... Drug Abuse shows that the nation continues to ... declines have slowed significantly compared to the dramatic ... troubling news, the survey also finds that smokeless ...
Breaking Medicine News(10 mins):Health News:Studies Quantify Cancer Risks From CT Scans 2Health News:Studies Quantify Cancer Risks From CT Scans 3Health News:Studies Quantify Cancer Risks From CT Scans 4Health News:UNC scientists coordinate study of link between insulin use and cancer in people with diabetes 2Health News:Marijuana Use No Longer Dropping Among U.S. Teens 2Health News:Marijuana Use No Longer Dropping Among U.S. Teens 3Health News:Marijuana Use No Longer Dropping Among U.S. Teens 4Health News:Health Reform Needs Enforceable National Workforce Strategy 2Health News:New Survey Shows Slow Decline in Youth Smoking, Troubling Increase in Smokeless Tobacco Use - Congress, States Must Step Up Tobacco Prevention Efforts 2Health News:New Survey Shows Slow Decline in Youth Smoking, Troubling Increase in Smokeless Tobacco Use - Congress, States Must Step Up Tobacco Prevention Efforts 3Health News:New Survey Shows Slow Decline in Youth Smoking, Troubling Increase in Smokeless Tobacco Use - Congress, States Must Step Up Tobacco Prevention Efforts 4Health News:New Survey Shows Slow Decline in Youth Smoking, Troubling Increase in Smokeless Tobacco Use - Congress, States Must Step Up Tobacco Prevention Efforts 5
... Turning Back Clock to Implement Bush Administration Proposal at Odds ... , WASHINGTON, May 1 Reaching back in ... the Bush Administration to cut seniors, Medicare funding by $1.05 ... five years) is completely at odds with the intent of ...
... Now we know what blocks the effects of a newly ... to treat individuals with cancer that is resistant to standard ... results have been obtained in some settings, in many cases ... lack of efficacy has now been uncovered by a team ...
... PLYMOUTH MEETING, Pa., May 1 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone ... the "Company") today announced that on April 29, 2009, ... Nasdaq Stock Market LLC indicating that the Company had ... in connection with the Company,s sale of 574,687 units, ...
... SQUARE, Pa., May 1 Many over-the-counter pain ... as the United States Food and Drug Administration ... final ruling, made Tuesday, calls for stronger labeling ... bleeding for non-steroidal anti-inflammatory drugs (NSAIDs) such as ...
... Biotech Inc. Sponsors Award Honoring the Work of Oncology ... finalists of CURE magazine,s 2009 Extraordinary Healer ... Inc., were announced during a special reception at the ... than 150 cancer patients and caregivers submitted nominations. ...
... or visually impaired are women WASHINGTON, May 1 Leading ... Women: Taking on Gender Inequities in Global Blindness Prevention," ... links between gender and blindness, poverty, disability and education. NGOs ... case studies and effective strategies that work in improving access ...
Other Medicine News:Health News:AHCA/Alliance: New Medicare Regulation Will Hurt Seniors, Cost Jobs, Perpetuate Inefficiency 2Health News:AHCA/Alliance: New Medicare Regulation Will Hurt Seniors, Cost Jobs, Perpetuate Inefficiency 3Health News:JCI online early table of contents: May 1, 2009 2Health News:JCI online early table of contents: May 1, 2009 3Health News:JCI online early table of contents: May 1, 2009 4Health News:JCI online early table of contents: May 1, 2009 5Health News:BMP Sunstone Compliance Receives Nasdaq Notice 2Health News:Consumers are Looking to Boiron Arnicare(R) as a Safer Option as FDA Enforces Stricter Labeling for Many Pain Relievers 2Health News:Consumers are Looking to Boiron Arnicare(R) as a Safer Option as FDA Enforces Stricter Labeling for Many Pain Relievers 3Health News:Winner of 2009 CURE Magazine Extraordinary Healer Award Announced 2Health News:Winner of 2009 CURE Magazine Extraordinary Healer Award Announced 3Health News:NGOs Unite to Bring Awareness to Inequities in Eye Care for Women 2
(Date:12/14/2009)... 14 Cancer patients in Finland have ... introduction of RapidArc® radiotherapy technology from Varian Medical ... only private radiotherapy clinic in the Nordic region. ... this fast and precise form of radiotherapy to ... of the abdomen and prostate. ,, RapidArc, which ...
(Date:12/14/2009)... 14 Accuray Incorporated (Nasdaq: ARAY ... radiosurgery, announced today that the first CyberKnife® Robotic ... the University Hospital of Liege. ,, The ... one of the largest hospitals in Euregio, a ... "With a full range of cancer treatments, University ...
(Date:12/14/2009)... Travelers of Interstate 70 west of Indianapolis will notice ... colorful when 10 multicolored art forms are installed on ... home , will eventually include 34 total pieces and ... Herron School of Art and Design, through the Basile ... Eli Lilly and Company (NYSE: LLY ) ...
Breaking Medicine Technology:Cancer Patients in Finland Gain Access to Advanced RapidArc Radiotherapy Treatments 2Cancer Patients in Finland Gain Access to Advanced RapidArc Radiotherapy Treatments 3First CyberKnife in Belgium to be Installed at Leading University Hospital 2First CyberKnife in Belgium to be Installed at Leading University Hospital 3Public Art to Complete Transformation of Key Gateway into Indianapolis 2Public Art to Complete Transformation of Key Gateway into Indianapolis 3Public Art to Complete Transformation of Key Gateway into Indianapolis 4ERT Appoints New Associate Director of Business Development Japan 13696 1ERT Appoints New Associate Director of Business Development Japan 13696 2ERT Appoints New Associate Director of Business Development Japan 13696 3MoxDuo 28TM 29 IR Demonstrates Fewer Side Effects Than Percocet 28R 29 4901 1MoxDuo 28TM 29 IR Demonstrates Fewer Side Effects Than Percocet 28R 29 4901 2MoxDuo 28TM 29 IR Demonstrates Fewer Side Effects Than Percocet 28R 29 4901 3MoxDuo 28TM 29 IR Demonstrates Fewer Side Effects Than Percocet 28R 29 4901 4Tips from the American Journal of Pathology 55407 1Tips from the American Journal of Pathology 55407 2Tips from the American Journal of Pathology 55407 3Tips from the American Journal of Pathology 55407 4Tips from the American Journal of Pathology 55407 5
... Significant anti-tumor activity of combination IV belinostat in ovarian ... cancer reported -, - Oral belinostat demonstrated to be safe ... clinical trials -, - CuraGen to provide a clinical update conference call today at 5:00 ... Eastern ...
... Inhibitor Mechanism, ROCKVILLE, Md., Oct. 25 ... clinical-stage pharmaceutical company developing,therapeutics for the treatment ... presentation of results for its cell cycle ... models. The results were,presented at the AACR-NCI-EORTC ...
Other Medicine Technology:CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 2CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 3CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 4CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 5CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 6CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 7CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 8CuraGen and TopoTarget Announce Presentation of Belinostat Clinical Trial Results at AACR-NCI-EORTC International Conference 9EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model 2EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model 3EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model 4
... features a patented Per-fit™ flexible PVC tube ... low-profile cuff specifically designed to reduce insertion ... patients anatomy. The kit s unique obturator/dilator ... snugly, allowing for an easier transition through ...
... The auto-expanding foam filled cuff ... of each patients trachea. During ... connectors insure the lowest possible ... sealing pressure throughout the ventilatory ...
... cost control. , ,Our full range ... of wound dressing components for the effective ... , ,Tray configurations include full trays, ... cannula for both rigid and flexible D.I.C.® ...
Disposable tracheostomy care tray....
Medicine Products: