Navigation Links
Researchers identify toehold for HIV's assault on brain
Date:11/14/2008

his a doctor with whom Gelbard had trained became ill and died of AIDS in less than two years. His friend's struggle, and the severity of his neurological symptoms, touched Gelbard. Gradually, with the support of mentors, Gelbard came to focus on the neurological effects of HIV. He now leads a group of researchers funded by the National Institute of Mental Health that is trying to identify or create the first treatment for the neurological effects of HIV, known collectively as neuroAIDS or HIV dementia.

Scientists have known that Tat, which helps HIV operate, replicate, and infect cells, is at the forefront of HIV's attack on the brain, bringing about severe inflammation. Immune cells within the brain go into overdrive, churning out substances that attract more immune cells, and white blood cells from the body flood in and join the fray, all clumping together to form destructive entities known as multinucleated giant cells.

"Suddenly the brain environment turns from nurturing to toxic, and the brain has to work much harder to send messages. Cells are on overdrive, spending a lot more energy to do the same things they used to do easily," said Gelbard, who is director of the Center for Neural Development and Disease at Rochester.

Other changes occur throughout the brain as well. Neurons that normally reach throughout the brain by forming networks of far-reaching, delicate extensions crucial for cell communication become damaged. Instead of sprouting healthy dendrites projections that resemble tiny trees neurons in the brain of an HIV patient have had parts of their dendrites abruptly torn off, in a process known as "synaptic pruning." The dendrites begin to look like a patch of severely damaged trees after a bad ice storm.

Such damage occurs in parts of the brain crucial for thinking, decision-making, and movement and memory. That accounts for symptoms like difficulties concentrating, forgetfulness, poor coordination, confusio
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
2. Researchers Use New Method to Control Bleeding in Hemophilia
3. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
4. Protein can nurture or devastate brain cells, depending on its friends, researchers find
5. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
6. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
7. Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting
8. USC researchers identify key mechanism that regulates the development of stem cells into neurons
9. Cornell researchers study showing evidence of a major environmental trigger for autism
10. Maastricht University researchers produce neural fingerprint of speech recognition
11. Researchers aim to over-stress already taxed mantle cell lymphoma cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... (PRWEB) April 27, 2015 Telematics Berlin ... tier 1&2 suppliers, associations, CE players and the government ... has opened to the car. This year’s panel on ... DG-Move at the European Commission, is an opportunity to ... and define a European Automotive Security Standard for years ...
(Date:4/27/2015)... 27, 2015 Attorney Dan Newlin, of the ... and protecting his clients, took that commitment to a whole ... code which makes it easier for existing and potential clients ... building his brand and added value to the firm’s services, ... area where Newlin has law offices. , “I knew the ...
(Date:4/27/2015)... Scooter Direct is now offering Pride ... price of only $929.00, marked down from the MSRP ... is known for offering quality mobility solutions to its ... wheel chairs, lift chairs, and their accessories at unbeatable ... of Go Go Traveller Elite, a senior store manager ...
(Date:4/27/2015)... On the top floor of the luxurious Beverly ... Los Angeles, CA, Per Wickstrom had an in-depth conversation ... of Orange County” Gretchen Christine Rossi. , In ... “Salute to the Oscars” celebration, sponsored by Choices Recovery, ... Wickstrom, Rossi felt that the evening’s interviews would not ...
(Date:4/27/2015)... Denver, Colorado (PRWEB) April 27, 2015 ... a ground-breaking solution to a problem that has ... marketing and advertising campaigns: by announcing the ... engine of its kind. , Officially launched ... industry and was created to index only marijuana-related ...
Breaking Medicine News(10 mins):Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3Health News:Dan Newlin Hashtags It With #Dan 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 3
... risk factor for active tuberculosis (TB) disease, according to a ... research analyzed data from nearly 17,000 individuals in Taiwan as ... While past studies have reported increased mortality among TB patients ... direct effect of smoking on active TB incidence using a ...
... ... professionals , ... August 23, 2009 -- An aging population and medical advances are a couple of ... (NRAF) is honoring the difference they make during the 2009 National Rehabilitation Awareness ...
... and methods, experts say simple CPR works best , SUNDAY, ... to participating in a flurry of activity when trying to ... IVs, placing a breathing tube, performing defibrillation to restart the ... advanced techniques saves lives as well as ordinary cardiopulmonary resuscitation, ...
... , LOUISVILLE, Ky., Aug. 22 A top medical ... Legion and colleague veterans service organizations can play a key role ... national suicide prevention coordinator, in pointing to the 5,000 self-inflicted deaths ... of our responsibility to own up to that. There,s no reason ...
... YouTube ... , ... August 22, 2009 -- Over 50 million American men suffer from hair loss. With that ... male pattern hair loss sufferer, Kevin Nalty (a.k.a. "Nalts") to raise awareness about hair loss ...
... Aug. 7, 2009 Dr. Glen Weiss of ... this week announced two significant advances in treating lung ... Weiss, M.D., an Associate Investigator in TGen,s Cancer and ... TGen Clinical Research Services at Scottsdale Healthcare, made both ...
Cached Medicine News:Health News:Smoking increases risk of developing active TB 2Health News:Smoking increases risk of developing active TB 3Health News:Medical Advances, Population Changes Fuel Demand for Rehabilitation Professionals 2Health News:It's Back to Basics to Save a Life 2Health News:It's Back to Basics to Save a Life 3Health News:The American Legion Can Play Key Role in Vets' Suicide Prevention, Says VA 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 3Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 4Health News:Advances in lung cancer research announced at conference 2
(Date:4/27/2015)... MILAN , April 27, 2015  USL di ... Italian province of Reggio Emilia, has implemented Zebra ... throughout the hospital. The Wireless Network Solution ... patients, medical records securely and in real time via ... available at all times. Zebra also provides employee and ...
(Date:4/27/2015)... 27, 2015  Novira Therapeutics, Inc., a privately held, ... of chronic hepatitis B virus (HBV) infection, today announced ... HBV core inhibitor candidate, NVR 3-778, at the 2015 ... of the Liver (EASL) in Vienna, Austria ... 3-778 from studies performed in a humanized UPA/SCID mouse ...
(Date:4/27/2015)... , April 27, 2015 - ... Process Patent by the State Intellectual Property Office of ... Based on Pooling Technology  - A New Treatment ... (CLI)    - About 20% of Elderly Urban ... in Women is Substantially Higher Than in Men. CLI is ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 4
Midstream Catch Kits...
... The BladderScan® is a portable, noninvasive ... is battery-operated, easy to use, and quickly ... minutes, you can use the BladderScan® to ... bladder volume. The BladderScan® supplies the information ...
... The Pediatric BladderScan® is ... Diagnostic Ultrasound's trusted family ... enabling healthcare providers to ... volume noninvasively, this easy-to-use, ...
... BVI 6300 Bladder Monitor is a ... the healthcare provider to enable patients ... ongoing basis. It is easy to ... so the patient can make informed ...
Medicine Products: