Navigation Links
Researchers identify the metabolic signaling pathway responsible for dyslipidemia
Date:4/5/2011

(Boston) - Researchers from Boston University School of Medicine (BUSM), including Yu Li, PhD, and other colleagues, have demonstrated that a nutrient sensing pathway is involved in the disruption of cellular lipid homeostasis in obese and insulin resistant mice fed a diet high in fat and sucrose. This nutrient sensing pathway, which is described in the current on-line issue of Cell Metabolism, may also have implications for the health benefits of polyphenols containing foods against fatty liver, hyperlipidemia, and atherosclerosis associated with obesity and type 2 diabetes.

Although it is well known that elevated serum cholesterol and triglyceride levels and fatty liver are caused by increased hepatic lipid synthesis and/or decreased lipid clearance in patients with obesity and diabetes, the underlying mechanistic pathways of these changes remains unknown.

The master regulators of lipid metabolism that were studied are called AMPK and SREBP. The researchers used a molecular biology approach, cell culture system and animal models to indicate that dysregulation of AMPK, an energy sensor, and SREBP, a protein that is important regulator for lipid biosynthesis, are affected in obesity. Mice fed a diet with high fat and high sucrose became obese and had insulin resistance and elevated circulating levels of cholesterol and triglyceride which led to accelerated atherosclerosis. In contrast, dietary supplementation with S17834, a polyphenol, significantly improved the metabolic disorder, lipid levels and atherosclerosis.

"Our findings suggest that AMPK suppression and SREBP activation are a root cause of fatty liver and hyperlipidemia in type 2 diabetes and its associated vascular complications such as atherosclerosis," said senior author Mengwei Zang, MD, PhD, an assistant professor of medicine at BUSM.

According to the researchers the potential health benefits of polyphenols have been gaining increasing interest. "In
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Alexandria, VA (PRWEB) July 31, 2014 ... Mesothelioma Applied Research Foundation, mesothelioma expert and executive ... APRN, stated that mesothelioma patients today have more promising ... In her talk, she mentioned several trials that have ... novel radiation treatments, while the focus of others is ...
(Date:7/31/2014)... Congress with bipartisan support would allow Medicare to test ... could improve the health of patients with chronic illness ... tests they need most. , The bill, introduced last ... grew out of a decade of work by health ... Policy and Innovation. It would allow Medicare Advantage plans ...
(Date:7/31/2014)... 31, 2014 Jacuzzi Luxury Bath, ... bathtub, has launched a new and improved website to ... , The Jacuzzi Luxury Bath website has been redesigned ... design and quality represented by the company’s products. The ... design and inspirational bathroom applications. “The site reflects our ...
(Date:7/31/2014)... at The Wistar Institute discovered that mice lacking ... age-related illnesses. The mice, which lack the TRAP-1 ... and spontaneous tumor formation when compared to normal ... the metabolic networks within cells. , In ... metabolism and has been shown to regulate energy ...
(Date:7/31/2014)... July 31, 2014 Global Markets ... provides an overview of the Brain Cancers therapeutic ... the therapeutic development for Brain Cancer, complete with ... drug target, mechanism of action (MoA), route of ... updates, and featured news and press releases. It ...
Breaking Medicine News(10 mins):Health News:‘More Promising Mesothelioma Clinical Trials than Ever Before,’ Says Expert 2Health News:‘More Promising Mesothelioma Clinical Trials than Ever Before,’ Says Expert 3Health News:Jacuzzi Luxury Bath Launches New and Improved Website 2Health News:'Rewired' mice show signs of longer lives with fewer age-related illnesses 2Health News:'Rewired' mice show signs of longer lives with fewer age-related illnesses 3Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 2Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 3Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 4
... October is National Physical Therapy,month and to ... Michigan residents to "Become a Physical Therapist or ... face uncertain economic times, the,physical therapy profession continues ... Director Aaron Bailey, PT, says there,is an urgent ...
... Oct. 30 Today URAC announced the,rollout ... technology,standards. The changes affect Health Web Site ... (Logo: http://www.newscom.com/cgi-bin/prnh/20030501/URACLOGO ), URAC, ... Privacy and Security standards to emphasize the ...
... International has named John T. Kelly, M.D., Ph.D. Chief Medical Officer. ... health and wellness of the users of Lifeclinic,s blood pressure monitors, ... ... MD (PRWEB) October 30, 2008 -- Lifeclinic International has ...
... CLEMSON Clemson University researchers developing imaging agents to ... received $180,000 from the Susan G. Komen Breast Cancer ... cancer deaths in American women. , The new method ... resonance imaging) that may help researchers look at different ...
... kick off American,Diabetes Month this November, the American ... Detroit, along with Eli,Lilly and Company,s national educational ... Diabetes Update, an educational program for people affected ... Saturday, November 1, at the Greater,Grace Temple, 23500 ...
... many hospitals have not,taken full advantage of opportunities ... see significant improvements in clinical,efficiencies, patient safety and ... Kermit Randa of Surgical Information Systems (SIS) and ... benefits realized through the,implementation of a best of ...
Cached Medicine News:Health News:The Physical Therapy Profession Remains in High Demand 2Health News:The Physical Therapy Profession Remains in High Demand 3Health News:URAC Rolls Out Revised Standards to Protect Personal Health Information and Boost Consumer Privacy on the Web 2Health News:Lifeclinic International Has Named John T. Kelly, M.D., Ph.D. Chief Medical Officer 2Health News:Susan G. Komen Breast Cancer Foundation awards grant for imaging-agent research 2Health News:American Diabetes Association and Eli Lilly and Company Unite to Educate and Empower African-Americans with Diabetes 2Health News:American Diabetes Association and Eli Lilly and Company Unite to Educate and Empower African-Americans with Diabetes 3Health News:Healthcare Providers Improve Financial, Clinical and Operational Efficiencies Through IT 2
(Date:7/31/2014)... July 31, 2014 TB Alliance, a ... better, faster and affordable treatments, announced the appointment ... President, External Affairs. Mr. Brock comes to TB ... Major Donor Relations for WWF International (formerly known ... Mr. Brock will guide the TB Alliance,s resource ...
(Date:7/31/2014)... -- Genomic Health, Inc. (Nasdaq: GHDX ) today announced ... on Thursday, August 7 at 4:30 p.m. Eastern Time to ... webcast will follow the release of the second quarter financial ... access the live conference call on August 7 at 4:30 ... the United States and ...
(Date:7/31/2014)... 31 2014  Northsight Capital, Inc. (OTCBB: NCAP) announced today ... Chairman and CEO of the company. Mr. Bluher has ... business development and investment banking. Mr. Bluher has over ... his career on Wall Street, Mr. Bluher was also ... Securities and Exchange Commission in Washington D.C. ...
Breaking Medicine Technology:TB Alliance Appoints Willo Brock Senior Vice President, External Affairs 2Genomic Health to Announce Second Quarter 2014 Financial Results and Host Conference Call on Thursday, August 7, 2014 2Genomic Health to Announce Second Quarter 2014 Financial Results and Host Conference Call on Thursday, August 7, 2014 3Genomic Health to Announce Second Quarter 2014 Financial Results and Host Conference Call on Thursday, August 7, 2014 4Northsight Capital, Inc. Names Wall Street Veteran John Bluher, Former EVP And General Counsel Of Knight Trading Group, Chairman And CEO. 2
... Alfacell Corporation,(Nasdaq: ACEL ) today announced that ... corporate secretary, will present an,overview of the company,s product ... at the UBS Global Life Sciences Conference at the ... Webcast of the presentation will be available on Alfacell,s,Web ...
... presented at the 43rd European Association for the Study of ... ... presented,today at the 43rd Annual Meeting of the European Association for ... the risk of ischemic cardiovascular disease in patients with type 2,diabetes. ...
Cached Medicine Technology:Alfacell Corporation to Present at UBS Global Life Sciences Conference 2ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes 2ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes 3
... (TSH) is a 32 kDa glycoprotein secreted ... pituitary gland [1]. The structure of human ... pituitary and placental gonadotropins, consisting of an ... these hormones and a unique beta-subunit, which ...
... (T4) is the primary active hormone synthesized ... gland [1]. T4 is synthesized via a ... by the follicular cells, (ii) iodination of ... to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT ...
... produced primarily by 5-monodeioination of thyroxine (T4) ... T3 production occurs at a rate which ... Release of T3 from the thyroid gland ... compared to 80-100 micrograms/day for T4. In ...
... protein-3 (IGFBP-3) is the main binding protein for ... component of the ~150 kDa ternary complex. This ... or IGF-II and ALS, allowing IGFBP-3, along with ... The molar concentration of IGFBP-3 in normal serum ...
Medicine Products: