Navigation Links
Researchers identify structure of apolipoprotein
Date:11/4/2011

(Boston) - Using a sophisticated technique of x-ray crystallography, researchers Xiaohu Mei, PhD, and David Atkinson, PhD, from Boston University School of Medicine (BUSM) have for the first time obtained an "image" of the structure and the precise arrangement of the atoms in a truncated form of the apolipoprotein A-I (apoA-I) molecule. The findings, which appear in the November issue of the Journal of Biological Chemistry, may lead to the development of new drugs to treat obesity, stroke and diabetes.

Errors in the regulation of the metabolism and transport of fats in the body are the number one cause of death and morbidity in the United States and most parts of the world. These problems are exemplified by the prevalence of diseases such as atherosclerosis, cardiovascular disease and stroke.

High blood levels of HDL or "good cholesterol" protect against atherosclerosis and cardiovascular disease. This protection is related HDL's role to remove cholesterol from cells in the tissues of the body. The major protein of HDL is called apoA-I. ApoA-I solubilizes fats and cholesterol and builds the HDL particle. ApoA-I plays important roles in the process of cholesterol removal by HDL.

ApoA-I interacts with another protein in the membrane of cells called the ABCA1 transporter, and removes cholesterol from the cells to form a "nascent" HDL particle.

In the blood, apoA-I in the nascent HDL activates the enzyme, lecithin-cholesterol acyltransferase (LCAT), which results in the solubilization of more cholesterol and the formation of a "mature" HDL particle. This HDL particle is transported in the blood stream to the liver where apoA-I binds to yet another cell membrane protein (hepatic SR-B1 receptor) and cholesterol is delivered to the liver and can be excreted from the body.

"Despite this central role in fat and cholesterol transport and metabolism, a detailed molecular understanding of apoA-I and how apoA-I forms an HD
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 17, 2014 This prestigious award ... that have made outstanding and innovative contributions to ... progression of private practice physical therapy by the ... Association. , On behalf of Performance Physical Therapy, ... CEO of Performance accepted the award at the ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Now in ... celebrate the best of the best in senior living ... is only given to communities and agencies that have ... SeniorAdvisor.com site. Of the nearly 100,000 providers currently listed ... Winners of the SeniorAdvisor.com Best of 2015 Awards are ...
(Date:12/17/2014)... -- Poor students get more fruits and vegetables at school ... But, the opposite is true for students from wealthier families. ... school may give a healthy boost to poor students, diets, ... family income level, students all ate a similar amount of ... study was published recently in the journal Preventive Medicine ...
(Date:12/15/2014)... December 15, 2014 A recent survey ... States women as impacting skin health and beauty were: ... of skin care.” Water and health advocate and radio ... recent article describing the survey and the Four C’s.* ... in every category discussed would benefit from paying attention ...
(Date:12/15/2014)... SIMpalm, a leading mobile app ... iPhone for its client, which allows users to keep ... specialized in finding the right wine. At the ... combined sensory, chemistry and wine information. All this information ... fingerprint.” Those wines that are close counterparts to one ...
Breaking Medicine News(10 mins):Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2
... decided to prepone the Japanese Encephalitis immunisation drive. This has ... they feel that it might not be he right time ... has been decided that the immunisation campaign scheduled to take ... 15, 2006 itself. 5.2 million doses of the Chinese made ...
... method to aid the formation of insulin crystals in ... University of Houston professor and his student, which holds ... // ,Peter Vekilov, associate professor of chemical ... chemical engineering, both in UH's Cullen College of Engineering, ...
... awakening to the growing menace of the drug problem, reports ... ,In order to effectively deal with the problem, police ... openly and stressing on the adverse effects of drugs like ... officials and religious leaders were stressing on the need to ...
... increased risk of fractures in later life, particularly during ... The Children's Hospital of Philadelphia and other researchers analysed ... had first experienced arthritis between ages one and 19. ... larger control group of 207,000 patients in a primary ...
... a recent study, women who use the contraceptive pill, ... risk of developing depression//. ,Adverse Psychiatric Reactions Information ... an effective contraceptive licensed as a hormone treatment for ... ,The women said they experienced serious depression ...
... states with urban states getting more for their premium ... (1-9 workers) pay an average 18% more in health ... workers), when actuarial value--the percentage of total medical expenses ... new Commonwealth Fund-supported study finds. ,In this ...
Cached Medicine News:Health News:Uttar Pradesh To Prepone The Japanese Encephalitis Immunisation Drive 2Health News:Uttar Pradesh To Prepone The Japanese Encephalitis Immunisation Drive 3Health News:Insulin Crystals Holds Promise In Diabetes research 2Health News:Health Insurance Plans Varies among States 2Health News:Health Insurance Plans Varies among States 3
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Electrocardiogram (ECG) Devices - Global Trends, Estimates ... http://photos.prnewswire.com/prnh/20130307/600769 Global ... million by 2016. The North America ... market share while Europe claims ...
(Date:12/15/2014)... , December 15, 2014 BerGenBio ... for aggressive drug resistant cancers, today announces that it ... private placing from new and existing investors. ... support the development of its pipeline of innovative cancer ... its lead drug candidate, BGB324, a first-in-class selective Axl ...
(Date:12/15/2014)... and BRIDGEWATER, N.J. , Dec. ... and Sanofi US (EURONEXT: SAN and NYSE: SNY) are ... to launch Cholesterol Counts , an awareness program ... their numbers, and the risks associated with high LDL-C ... www. CholesterolCounts .com to take a brief poll ...
Breaking Medicine Technology:Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4BerGenBio Completes NOK90 Million Fundraising 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6
... 1 Reproductive Partners Medical Group, Inc. announces their ... a financial incentive for patients with good embryo quality ... the chance of twins by transferring a single embryo. ... is reducing the number of multiple pregnancies, even twin ...
... , ... ), a leading online retailer of health, beauty, vision, and ... day ever as customer orders were the highest in company ... Beauty.com web stores featured more special offers than in ...
Cached Medicine Technology:Reproductive Partners Announces Elective Single Embryo Transfer (eSET) Encouragement Program 2drugstore.com, inc. Has Best Day Ever on Cyber Monday 2drugstore.com, inc. Has Best Day Ever on Cyber Monday 3
... TOPCON Trial Lens Set offers ... powers, featuring special corrected curve ... thickness and air spacing between ... exact correction to be read ...
... The AIT-8Bs instrument design ... The table is fully wheelchair ... loads up to 100 lbs. ... for Topcon retinal camera units ...
This isnt just another new stand weve come up with, this is absolutely revolutionary!...
The LM-990A is the most completely automatic lensemeter ever created. It even measured monocular and binocular PD automatically....
Medicine Products: