Navigation Links
Researchers identify role for protein linked to obesity, type 2 diabetes
Date:12/17/2012

DALLAS Dec. 17, 2012 Researchers at UT Southwestern Medical Center have taken another step toward better understanding the metabolic functions of obesity and its connection to type 2 diabetes.

Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern, led a group of researchers in a recent multicenter study published in Nature Medicine that successfully identified ways to manipulate the protein mitoNEET. This is the first time the protein has been effectively altered to expand fat tissue in a way that allows subjects in this case, mice to remain metabolically healthy.

MitoNEET is a key component of a cell's mitochondrion, which serves as the cell's energy powerhouse. When the levels of MitoNEET protein were elevated inside the fat cells of rodents, more fat was stored in the adipose tissue, thereby keeping toxic lipids away from other types of cells. This sequestration resulted in extremely obese yet metabolically healthy mice that displayed no signs of type 2 diabetes. In contrast, when MitoNEET levels were decreased, the mice became lean but unhealthy, and developed pre-diabetic conditions such as failure to metabolize glucose properly.

"The manipulation of mitochondrial activity in fat tissue is a very powerful approach to control how much excess energy we store in our bodies and where we store it. We have heretofore underestimated the importance of mitochondrial pathways in our fat cells and their influence on how we manage our weight," said Dr. Scherer, senior author of the three-year study and Professor of Internal Medicine and Cell Biology at UTSW.

The b
'/>"/>

Contact: Remekca Owens
remekca.owens@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify role for protein linked to obesity, type 2 diabetes
(Date:3/2/2015)... March 02, 2015 Secura Consultants ... relationship with First Protective Insurance Group of Birmingham, ... allow First Protective affiliated advisors to access the ... that Secura Consultants delivers. , Secura ... leader in the design and implementation of insured ...
(Date:3/1/2015)... March 01, 2015 Women’s Excellence is ... Obstetric terms on their website. There are over 75 ... the time. , “This gives our patients a better ... medical terminology that they may not understand. With this resource, ... is mobile optimized) and find terms and phrases that they may ...
(Date:3/1/2015)... NC (PRWEB) March 01, 2015 Researchers ... reason that so many sheet metal workers contract malignant ... this new report on its website. Click here ... Center for Construction Research and Training monitored 17,345 sheet ... a disproportionate number of them died of mesothelioma ...
(Date:3/1/2015)... 01, 2015 Indiana Fiber Network, ... Provider, announces NewWays Networking, LLC (NewWays) selected IFN ... with IFN, NewWays is well positioned to scale ... for Internet bandwidth in rural parts of Indiana,” ... to Cory Childs IFN Enterprise Sales Manager, IFN ...
(Date:3/1/2015)... Vancouver, WA (PRWEB) February 28, 2015 CrossFit ... This spring they are offering a special discount to new ... who sign up for a three month contract will receive ... each month individually would cost members $440. The three ... $88 per month, and then the fourth month comes in ...
Breaking Medicine News(10 mins):Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2Health News:New Study Finds Indirect Asbestos Exposure Can Raise Mesothelioma Risk for Sheet Metal Workers, According to Surviving Mesothelioma 2Health News:NewWays Networking Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2
... was no better than placebo, study finds , , MONDAY, ... (Trileptal) does not seem to prevent migraines, as once ... than 28 million Americans, and certain epilepsy drugs have ... headaches. For this reason, many assumed that oxcarbazepine would ...
... at Annual Meeting of the American Academy of ... ... NeoStrata today released new,clinical data that demonstrates significant benefits in combining,microdermabrasion ... products in improving the appearance,and texture of facial skin. The data ...
... for donations is spiraling for older couples wanting to start ... ... Radical shifts in parenting,trends have fertility experts at Reproductive Endocrinology Associates of,Charlotte ... in 2008 -- including new outreach through the Internet --,in efforts to ...
... the day that we,celebrate love approaches, many people with memory-impaired ... sustain a loving,relationship with someone who no longer knows who ... a new understanding of love itself., "It,s important to ... matters most is doing things that make him or her ...
... Show All 89 Inspected Pennsylvania Facilities Meet Federal,Standards, ... of,Environmental Protection reported today that all of the ... are operating within,the guidelines set forth by the ... each of Pennsylvania,s approximately 400 certified,mammography facilities annually ...
... saturate TV, radio, and print with anti-Meth ... ... The Illinois Meth Project,today launched a campaign to prevent first-time methamphetamine ... a research-based prevention program that educates people,about the dangers of Meth ...
Cached Medicine News:Health News:Epilepsy Drug Doesn't Prevent Migraines 2Health News:NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin 2Health News:Charlotte IVF Experts Issue Urgent Call for Egg Donors, Eye New Recruiting Tools 2Health News:Loving the Memory-Impaired: A New Perspective on Valentine's Day 2Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 2Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 3Health News:Pennsylvania DEP Releases 4th Quarter 2007 Mammography Inspection Results 4Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 2Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 3Health News:Illinois Meth Project Launches Large-Scale Meth Prevention Campaign 4
(Date:2/27/2015)... YORK , Feb. 27, 2015  Pomerantz LLP ... Pharmaceuticals, Inc. ("Vitae" or the "Company") (NASDAQ: ... Robert S. Willoughby at rswilloughby@pomlaw.com or ... Vitae and certain of its officers and/or directors have ... Act of 1934.  On February 27, ...
(Date:2/27/2015)... 2015 Securities lawyers at Dunnam & ... Ltd. (NASDAQ: SLXP ) in connection with ... investors are encouraged to contact attorney Hamilton Lindley by ... focuses upon the shareholder value of the transaction. Under ... only $158.00 per share in cash. At least one ...
(Date:2/27/2015)... Report Details   ... R&D progress, and predicted revenues ,Where is the market ... commercial prospects for this market and related technologies? Visiongain,s ... trends to 2025, discussing data, opportunities and prospects. ... regenerative medicine : cell-based therapies that aim to restore ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8
... VIEW, Calif., Feb. 23, 2011 Omnicell, Inc ... of medication management systems to healthcare facilities, today announced ... 100 healthcare executives were polled to identify trends in ... purchasing decisions. The survey found that the majority of ...
... Biomatrica, Inc., a leader in room temperature biostability ... In-Q-Tel (IQT). IQT is the independent, strategic investment ... the mission of the U.S. Intelligence Community. ... has pioneered recent innovations in ambient storage of ...
Cached Medicine Technology:75 Percent of Hospital IT Leaders View Interoperability Between Vendor Systems as Critical to Operational Effectiveness in Healthcare Settings 2Biomatrica Secures Strategic Investment from IQT 2Biomatrica Secures Strategic Investment from IQT 3
... of the series. It has the ability to photograph ... cornea. The model comes with a 9 high-resolution black ... patients corneal endothelium, you simply ask the patient to ... The left side of the chin rest allows you ...
The simplest, most accurate Ortho-K lens fitting system ever!...
... The Euclid Systems Orthokeratology (oprifocon A) ... contact lenses used for orthokeratology, a ... The patient wears these lenses overnight ... During the day, nearsightedness is temporarily ...
... These are rigid gas permeable contact ... process that temporarily corrects nearsightedness (myopia). The ... and removes them upon wakening. During the ... ,The Paragon CRT and Quadra RG contact ...
Medicine Products: