Navigation Links
Researchers identify role for protein linked to obesity, type 2 diabetes
Date:12/17/2012

DALLAS Dec. 17, 2012 Researchers at UT Southwestern Medical Center have taken another step toward better understanding the metabolic functions of obesity and its connection to type 2 diabetes.

Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern, led a group of researchers in a recent multicenter study published in Nature Medicine that successfully identified ways to manipulate the protein mitoNEET. This is the first time the protein has been effectively altered to expand fat tissue in a way that allows subjects in this case, mice to remain metabolically healthy.

MitoNEET is a key component of a cell's mitochondrion, which serves as the cell's energy powerhouse. When the levels of MitoNEET protein were elevated inside the fat cells of rodents, more fat was stored in the adipose tissue, thereby keeping toxic lipids away from other types of cells. This sequestration resulted in extremely obese yet metabolically healthy mice that displayed no signs of type 2 diabetes. In contrast, when MitoNEET levels were decreased, the mice became lean but unhealthy, and developed pre-diabetic conditions such as failure to metabolize glucose properly.

"The manipulation of mitochondrial activity in fat tissue is a very powerful approach to control how much excess energy we store in our bodies and where we store it. We have heretofore underestimated the importance of mitochondrial pathways in our fat cells and their influence on how we manage our weight," said Dr. Scherer, senior author of the three-year study and Professor of Internal Medicine and Cell Biology at UTSW.

The b
'/>"/>

Contact: Remekca Owens
remekca.owens@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify role for protein linked to obesity, type 2 diabetes
(Date:11/22/2014)... Steven Reinberg HealthDay Reporter ... outcomes are better when patients are treated in an ambulance ... drugs, German researchers report. The sooner patients get the ... the outcome after a stroke, the researchers noted. For the ... first hour after stroke symptoms start, the researchers said. ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 CRN International, ... veteran radio industry sales professional to its award-winning team. ... 30 years of leadership and sales experience to CRN. ... assume the title of Director of Strategy and Development, ... Robert O’Mara. , Heinemann will handle a wide range ...
(Date:11/21/2014)... -- Seeking to make it tougher for people to ... on Thursday approved a new hydrocodone tablet that,s designed ... by the brand name Vicodin -- is a powerful ... in dangerous addictions across the United States. The ... is an extended-release tablet to treat pain severe enough ...
(Date:11/21/2014)... (HealthDay News) -- Scientists say they,ve mapped the genome -- ... British man,s brain, in hopes it might help others with ... the journal Genome Biology , the tapeworm was removed ... ethnicity. "This infection is so rare worldwide and completely ... ... until the worm was pulled out from the brain," ...
(Date:11/21/2014)... Mass. (PRWEB) November 21, 2014 Center ... free workshops titled “Massachusetts Insurance Funding for Autism Workshops” ... (ASD) navigate their way through the insurance coverage process. ... under Massachusetts law and the most effective ways to ... Thursday, Dec. 4 from 6-8:00 p.m. at 331 Montvale ...
Breaking Medicine News(10 mins):Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 2Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 3Health News:Radio Industry Veteran Joins CRN International’s Sales Organization in Detroit 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 3Health News:Ick! Tapeworm Infecting Man's Brain Yields Genetic Secrets 2Health News:Center for Autism and Related Disorders to Host Massachusetts Autism Insurance Workshops for Parents 2
... A new study shows there is some truth in the ... the brain active. It is long been believed that mental ... the Rush Alzheimer's Disease Centre in the US now reveal ... ongoing Religious Orders Study, involving the cognitive health of older ...
... research has established that a decreased white blood ... aggressive periodontitis.The scientists showed that at six weeks of ... of their alveolar bone whereas the normal mice had ... which anchors teeth in place, is an indication of ...
... said that older hospital patients with delirium run a ... condition. Researchers suggested there's a need for research to ... to investigate interventions that can be made after discharge ... study covered 361 patients aged 65 or older, of ...
... Better health may be only a dash and sprinkel ... found that herbs, in addition to making food tastier, ... potential anticancer benefits when supplementing a balanced diet.Herbs have ... including garlic, the researchers say. Their findings appear in ...
... was found using new technology which helps prevent stroke. One ... by ultrasound, at any blockages in the carotid arteries that ... the US have pioneered the use of a portable device, ... 20 people, this was used to take two different images ...
... measles, mumps and rubella is in short supply. The ... with shortfalls caused by production problems, fewer drugmakers// and ... ,The situation is so bad that 8 of the ... tetanus, diphtheria and a pneumococcal vaccine used to prevent ...
Cached Medicine News:Health News:Herbs: rich soure of antioxidants 2
(Date:11/21/2014)... 21, 2014  Heated dialogue in recent months about ... cancer treatments to Gilead,s new hepatitis C drug Harvoni® ... world questioning what it means to put a price ... And while drug pricing is one of the ... both a general business and ethical standpoint – it ...
(Date:11/21/2014)... , Nov. 21, 2014 ... the European Medicines Agency (EMA) has granted ... company,s lead product candidate, for the treatment ... a rare, severely disabling genetic disease characterized ... swelling (flare-ups) and new abnormal bone formation. ...
(Date:11/21/2014)... , Nov. 20, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: ... , Chief Executive Officer, will be presenting at the 26 ... York Palace Hotel in New York . ... at 2:00 PM ET. In addition, Mr. Krakauer and ... for separate one-on-one meetings during the day. ...
Breaking Medicine Technology:"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 2Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 3
... IRIDEX Corporation (NASDAQ: IRIX ) today announced that it ... after the market closes on Thursday, March 1, 2012. ... a conference call with the investment community at 5:00 ... 2012 to discuss the results of the quarter and ...
... Medical Corp.,s (Nasdaq Market: ESMC) subsidiary,  Sonomed Escalon™ announced ... AXIS™ Image Management System at the recent World Ophthalmology ... Matthew Carnevale, Chief Technical Officer, stated that ... ophthalmic diagnostic imaging management, and provides an entirely new ...
Cached Medicine Technology:Sonomed Escalon™ Announces Release of AXIS™ iPad App 2Sonomed Escalon™ Announces Release of AXIS™ iPad App 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: