Navigation Links
Researchers identify role for protein linked to obesity, type 2 diabetes
Date:12/17/2012

DALLAS Dec. 17, 2012 Researchers at UT Southwestern Medical Center have taken another step toward better understanding the metabolic functions of obesity and its connection to type 2 diabetes.

Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern, led a group of researchers in a recent multicenter study published in Nature Medicine that successfully identified ways to manipulate the protein mitoNEET. This is the first time the protein has been effectively altered to expand fat tissue in a way that allows subjects in this case, mice to remain metabolically healthy.

MitoNEET is a key component of a cell's mitochondrion, which serves as the cell's energy powerhouse. When the levels of MitoNEET protein were elevated inside the fat cells of rodents, more fat was stored in the adipose tissue, thereby keeping toxic lipids away from other types of cells. This sequestration resulted in extremely obese yet metabolically healthy mice that displayed no signs of type 2 diabetes. In contrast, when MitoNEET levels were decreased, the mice became lean but unhealthy, and developed pre-diabetic conditions such as failure to metabolize glucose properly.

"The manipulation of mitochondrial activity in fat tissue is a very powerful approach to control how much excess energy we store in our bodies and where we store it. We have heretofore underestimated the importance of mitochondrial pathways in our fat cells and their influence on how we manage our weight," said Dr. Scherer, senior author of the three-year study and Professor of Internal Medicine and Cell Biology at UTSW.

The b
'/>"/>

Contact: Remekca Owens
remekca.owens@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify role for protein linked to obesity, type 2 diabetes
(Date:5/21/2013)... May 21, 2013 Daily Gossip Magazine published ... their readers and keep people informed on the latest weight ... reporters have prepared an in-depth review of Kyle ... useful for readers who want to lose weight or stay ... Daily Gossip the program was created by a popular fitness ...
(Date:5/21/2013)... Primary care practice transformation on a large scale ... efforts aimed at achieving better outcomes, better value ... that transformation toward the patient-centered medical home model ... environment, the U.S. Department of Health and Human ... 14 studies to learn more about the processes ...
(Date:5/21/2013)... May 21, 2013 HealthSmart continues to ... national presence has required the hiring of new talent ... is pleased to announce that Dawn Powell has joined ... as the Director of Account Management in the Central ... in Irving, Texas. With extensive client management, employee benefits, ...
(Date:5/21/2013)... According to a May 13, 2013 New ... Botox,” Botox injections have become the most popular ... (Go to goo.gl/8iYbD). Although it is mostly associated with women, ... injection makes facial wrinkles less visible by paralyzing facial muscles. ... three months. This means that people who are conscious about ...
(Date:5/21/2013)... Angeles, CA (PRWEB) May 21, 2013 ... sports organization, and Bodybuilding.com, the largest online retailer of ... you a new reality-based sports show, Warrior Island. ... vote on; YouTube, Facebook & Twitter, with our unique ... Warrior Island maroons these elite fighters on an island ...
Breaking Medicine News(10 mins):Health News:Customized Fat Loss Plan Review and Diet Secrets Revealed By Daily Gossip Magazine 2Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 2Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 3Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 4Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 5Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 6Health News:New Talent Joins the HealthSmart Account Management Team 2Health News:Botox – Is the World’s Most Popular Cosmetic Procedure Safe? 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 3
... Carolina Department of Health and Human Services; Announces ... 17 Curam Software, the leading provider of ... another major name to its growing portfolio of ... North Carolina Department of Health and Human Services ...
... 17 The following event was announced today by ... The Greater Los Angeles Red Cross is hosting ... Emergency Operations Center (EOC), which is ready to be ... even a disaster the size of Hurricane Katrina. A ...
... THE EUROPEAN COLLABORATIVE PROJECT -, ... March 17 /PRNewswire-FirstCall/ - Hard to Treat Diseases ... that the IBISS Group members from Slavica Biochem ... scientists, clinicians, management experts, small enterprises and industry ...
... for Preexisting Conditions WASHINGTON, March 17 The ... non-profit organization dedicated to the mission of creating ... through public policy reform at the state and ... (D-WV) and Representative Joe Courtney (D-CT) for introducing ...
... comes as use of stimulant for enhanced mental function is ... -- A drug used to treat narcolepsy is increasingly being ... evidence that it also harbors the potential for abuse. , ... brain, the new study shows. , "This drug does seem ...
... 3rd Annual Walk for Lupus Now Washington will occur on ... Pennsylvania Avenue, N.W. between 13th and 3rd Streets. The Lupus ... year,s turnout to double, reflective of the 70,000+ people with ... million in the U.S. Lupus is a chronic, autoimmune disease ...
Cached Medicine News:Health News:Ireland's Curam Software Charts New Lead in U.S. Market 2Health News:State-of-the-Art Preparedness: L.A. Red Cross Opens Advanced Emergency Operations Center 2Health News:Hard To Treat Diseases (HTDS) - Large scale integrating project HEALTH 2009 2Health News:National Patient Advocate Foundation Hails Senator Rockefeller, Representative Courtney for Introducing Preexisting Conditions Bill, Ensuring Patient Access to Health Coverage 2Health News:Narcolepsy Drug Might Be Addictive 2Health News:Narcolepsy Drug Might Be Addictive 3Health News:Third Annual Walk for Lupus Now Washington Set for April 18 2
(Date:5/21/2013)... SAN JOSE, Calif. , May 21, 2013 /PRNewswire/ ... of the prestigious 2013 TiE50 "Top Startup" Award at ... for its innovation, strong management team and quality of ... th at the Santa Clara ... is a highly influential list of the most enterprising ...
(Date:5/21/2013)... , May 21, 2013 Kepner-Tregoe (KT), ... announced that 13-year veteran Chris Geraghty ... Geraghty,s experience includes more than 20 years serving ... with manufacturing organizations. He succeeds Ray ... as Kepner-Tregoe,s Chairman of the Board and CEO. ...
(Date:5/21/2013)... BURLINGTON, Mass. , May 21, 2013 ... leading research and advisory firms for pharmaceutical ... of an emerging agent on key efficacy ... disease progression, has the most influence over ... for advanced/metastatic hormone-receptor (HR-) positive, HER2-negative breast ...
Breaking Medicine Technology:RenovoRx Named Winner of 2013 TiE50 "Top Startup" 2Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 2Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 3Thought-Leader Opinion and Clinical Data Indicate that Emerging Agents from Two Drug Classes Have Efficacy Advantages Over Currently Used Therapies for HR-Positive, HER2-Negative Breast Cancer 2
... OF FIRST PHASE III TRIAL SHOW SIGNIFICANT, DECREASES ... ... FIBROMYALGIA PATIENTS, , PALO ALTO, Calif., and BRUSSELS, Belgium, ... UCB (Euronext Brussels: UCB),announced today positive preliminary top-line results from the first ...
... EMERYVILLE, Calif., Nov. 20 Bionovo, Inc.,(Nasdaq: BNVI ... 1B,clinical trial of their lead drug candidate for advanced metastatic ... in Atlanta, Georgia. The Company,s oral presentation was selected,as ... part of the Best of the,SIO Session on November 20, ...
Cached Medicine Technology:Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia 2Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia 3Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia 4Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia 5Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia 6Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology 2Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology 3Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology 4Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology 5
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... a critical component of pain relief, functional ... Lumbosacral Bracing System™ offers the practitioner multiple ... of immobilization, unparalled comfort, and the ability ... even if they gain or lose weight. ...
... Aspen® Cervical Collars were designed to optimize ... better patient outcomes. The structure of the ... restriction without producing painful pressure points that ... patient compliance. For the ultimate in comfort, ...
... This comfortable pre-fabricated orthosis is designed ... distal third humeral diaphyseal fractures. The ... circumferential soft tissue compression for optimal ... range-of- motion of both shoulder and ...
Medicine Products: