Navigation Links
Researchers identify proteins in lung cancer cells that may provide potential drug targets
Date:11/24/2009

(Boston) Researchers from Boston University School of Medicine (BUSM) and the Boston University Biomedical Engineering Department have identified a number of proteins whose activation allows them to distinguish between cancer and normal cells with almost 97 percent accuracy. In addition, the BU researchers have developed a new computational strategy to analyze this data and specifically identify key biological pathways (molecular circuits) that are active in cancer and "dormant" in normal cells. The study which appears in the November 25th issue of PLoS ONE, will ultimately lead to the development of drugs specifically aimed to inhibit these proteins.

According to the BU researchers, there are many features that make cancer cells different from normal cells. They look different histologically, they proliferate and divide at different rates, they are immortal unlike normal cells, and are less communicative with their neighbor cells. They are also more "selfish" in refusing to commit suicide (programmed cell death) which normal cells do when their genomes become unstable.

Much of the cellular machinery involved with these biological processes is controlled by a command control and communication system called signal transduction. Signal transduction is in large part controlled by a process called phosphorylation. When a protein is phosphorylated it either becomes active or repressed depending on its special function. "Therefore, identifying the phosphorylation status of proteins in cancer cells versus normal cells provides us with a unique ability to understand and perhaps intervene with the command and control center of cancer cells," said co-senior author Simon Kasif, PhD, who is the co-director of the Center of Advanced Genomic Technology and a professor in the department of biomedical engineering at BU. "Drugs are most effective on cancers when they attack the proteins that are activated," he added.

While cancers are highly heterogeous in their make-up, the BU researchers believe that a drug that would target this collection of proteins would be effective treatment for most lung cancers.

"This is the first statistically validated phosphopeptide signature to diagnose any disease, much less cancer or lung cancer," explained senior co-author Martin Steffen, MD, PhD, an assistant professor of pathology and laboratory medicine at BUSM, and director, Proteomics Core Facility at BUSM.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers Identify Possible Causative Mutation for Crohn's Disease: Crohn's & Colitis Foundation Annual Conference to Present Emerging Research
2. Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
3. Researchers identify role of gene in tumor development, growth and progression
4. On the trail of a vaccine for Lyme disease: Yale researchers target tick saliva
5. UCLA researchers create fly paper to capture circulating cancer cells
6. Researchers focus on helping dying patients take care of unfinished business
7. Mount Sinai researchers to test first gene therapy For Alzheimers patients
8. Wistar researchers show targeting normal cells in tumors slows growth
9. K-State researchers studying link between climate change and cattle nutritional stress
10. Cornell Researchers Identify a Weak Link in Cancer Cell Armor
11. Researchers notch a victory toward new kind of cancer drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... ... reminds us that May is National Stroke Awareness Month. According to the Centers for ... the United States; someone has one every 40 seconds. Annually, almost 800,000 strokes occur ... A stroke is when blood flow to the brain is blocked or when a ...
(Date:4/28/2016)... MA (PRWEB) , ... April 28, 2016 , ... A ... were typical among 18 states studied, the Workers Compensation Research Institute (WCRI) ... The WCRI study, CompScope™ Benchmarks for Kentucky, 16th Edition , found that indemnity ...
(Date:4/28/2016)... ... April 28, 2016 , ... SyncDog, Inc. ... its leading secure mobility workstation suite, SentinelSecure™, at MobileIron’s 6th annual Mobile First ... this will be MobileIron’s 6th Mobile First Conference and will feature immersive training, ...
(Date:4/28/2016)... ... 2016 , ... For the 10,000 Americans who turn 65 on any given ... overall well-being: mental health. Now, a new book—Staying Sharp For Dummies (Paper; ISBN: 978-1-119-18779-0; ... which can include everything from honing your memory and managing stress to eating healthy ...
(Date:4/28/2016)... , ... April 28, 2016 , ... The USDA recently ... based on the latest nutritional science. While there is a lot of information available ... health, according to the April 2016 issue of Harvard Men's Health Watch . ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016 Transparency Market ... Devices Market - Global Industry Analysis, Size, Share, Growth, ... report, the global skincare devices market was valued at ... expand at a CAGR of 10.1% from 2015 to ... Browse the full Skincare Devices Market (Treatment Device - ...
(Date:4/27/2016)... Shire plc (LSE: SHP, NASDAQ: SHPG ... will present at the Deutsche Bank 41st Annual Health Care ... May 04, 2016, 10:00 am EDT (15:00 BST). ... and Webcasts section of Shire,s Investor website at http://investors.shire.com/presentations-and-webcasts/ ... on this same website for approximately 90 days. ...
(Date:4/27/2016)... 27, 2016 The global  ... 2.06 billion by 2022, according to a new ... awareness towards a healthy lifestyle is expected to ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ... rising health treatment expenditure has urged consumers to ...
Breaking Medicine Technology: