Navigation Links
Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
Date:8/30/2009

that are upregulated during enhanced development of osteoclasts, such as NFATc1, but few studies have identified genes that are downregulated in the process. To fill this knowledge gap, scientists at Hospital for Special Surgery, collaborating with researchers at other institutions, used microarray technology to conduct a genome-wide screen to identify genes that are downregulated during the formation of osteoclasts. They found that expression of IRF-8 was reduced by 75 percent in the initial phases of osteoclast development.

The researchers then genetically engineered mice to be deficient in IRF-8 and gave the animals x-rays and CT (computed tomography) scans to analyze IRF-8's influence on bone. They found that the mice had decreased bone mass and severe osteoporosis. Experiments demonstrated that this was due not to a decreased number of osteoblasts, but because of an increased number of osteoclasts. The researchers concluded that IRF-8 suppresses the production of osteoclasts.

Tests in human cells confirmed these findings. This included a study that showed that silencing IRF-8 messenger RNA in human osteoclast precursors with small interfering RNAs resulted in enhanced osteoclast production. In other words, decreased IRF-8 means more osteoclasts are produced.

This led the investigators to examine the effect of IRF-8 on the activity of a protein called NFATc1 that was previously reported to interact with IRF-8. They found that IRF-8 inhibited the function and expression of NFATc1. This makes sense given that upregulation of NFATc1 is involved in triggering osteoclast precursor cells to turn into osteoclasts.

"This is the first paper to identify that IRF-8 is a novel key inhibitory factor in osteoclastogenesis [production of osteoclasts]," said Dr. Zhao. "We hope that the understanding of this gene can contribute to understanding the regulatory network of osteoclastogenesis and lead to new therapeutic approaches in the futur
'/>"/>

Contact: Phyllis Fisher
fisherp@hss.edu
212-606-1197
Hospital for Special Surgery
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... By Kathleen Doheny ... -- Losing a spouse may be linked to multiple health ... new study. For certain seniors, widowhood may even delay ... mild memory problem, losing the spouse was associated with a ... stayed married," said study researcher Dr. Bryan Woodruff. ...
(Date:7/14/2014)... Connecticut (PRWEB) July 14, 2014 ... is celebrating its Grand Opening on Monday, July ... Connecticut 06830. The celebration will last all week ... all new patients. Everyone is welcomed to attend. ... M.D. who provides physician-administered skincare, anti-aging, weight loss ...
(Date:7/14/2014)... 2014 Many people are unhappy with ... surgery to reduce a “double chin.” A new ... need to go under the knife. Jawflex is a ... muscles, therefore tightening the skin in that area and ... is used for facial exercise, double chin elimination and ...
(Date:7/14/2014)... VA (PRWEB) July 14, 2014 Since ... a local icon to the Tysons Corner skyline and ... becoming its own municipality, known simply as “Tysons”, the ... Tysons Hotel. In addition to Tysons becoming its ... located in the heart of Tysons brings an evolution ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 Kenn Renner recently ... The video is meant to describe the business on ... broker and national speaker – Kenn Renner – is internationally ... marketing, and goal setting techniques. , Investing in real estate ... Some people do it as their career, while others like ...
Breaking Medicine News(10 mins):Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:Jawflex | Double Chin Exercise for Double Chin Reduction 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 3Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 4
... March 24 During National Root,Canal Awareness Week (March ... articles,is available for publication courtesy of The Michigan Association ... about,root canals and new technology that can make the ... health can affect your overall health, Oral health ...
... Newsstands March 25, MILWAUKEE, March 24 As ... Home, the largest cooking magazine in,America, introduces Healthy Cooking ... for a healthier life. With its mix of recipe ... by nutritionists and health,experts, Healthy Cooking makes it easier ...
... /Xinhua-PRNewswire-FirstCall/ -- China Medical,Technologies, Inc. (the "Company") ... device company that develops, manufactures and markets ... intensity focused ultrasound,tumor therapy systems, today announces ... ("CE Mark") for its two semi-automatic ECLIA,analyzers ...
... dementia patients and ... families regain what was once lost, ... Americans,including 250,000 Ohioans, struggle with the devastating effects of,Alzheimer,s ... greater,Cleveland area offers new hope to Alzheimer,s patients and ...
... March 24 Linden LLC, a health care and ... a controlling,interest in its portfolio company, Ranir LLC, to ... Kiphart. In addition to being a private,investor, Mr. Kiphart ... acquired Ranir in April 2005 and will maintain a ...
... the samples spend more on prescription drugs, study says ... receive free drug samples from their doctors end up ... than people who don,t receive free samples, a new ... free samples spent about $166 in out-of-pocket costs on ...
Cached Medicine News:Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 2Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 3Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 4Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 5Health News:Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy 6Health News:Taste of Home Magazine Launches Healthy Cooking 2Health News:China Medical Technologies Receives CE Mark for Two ECLIA Analyzers and 15 Reagents 2Health News:Cleveland Area Homewatch CareGivers Unveil New Alzheimer's Program 2Health News:Linden Announces Sale of Ranir to Kayak Holdings 2Health News:Linden Announces Sale of Ranir to Kayak Holdings 3Health News:Free Drug Samples Hike Out-of-Pocket Costs 2Health News:Free Drug Samples Hike Out-of-Pocket Costs 3
(Date:7/14/2014)... Valeant Pharmaceuticals International, Inc. (NYSE: ... it has filed a premerger notification under the ... the U.S. Federal Trade Commission (FTC) relating to ... About Valeant Pharmaceuticals International, Inc. ... VRX) is a multinational specialty pharmaceutical company that ...
(Date:7/14/2014)... , July 14, 2014 Synthetic ... technology partnership with global bioengineering leader DNA2.0, ... for quick-to-market products. The integration ... machine learning optimization technologies, such as ProteinGPS™ ... process of engineering proteins in the Pareto ...
(Date:7/14/2014)... 2014  Abbott (NYSE: ABT) announced today that it will ... Mylan for equity ownership of a newly formed entity ... Abbott,s developed markets pharmaceuticals business, and will ... of approximately $5.3 billion based on Mylan,s closing stock ... business generated approximately $2 billion in sales in 2013. ...
Breaking Medicine Technology:Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 2Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 3Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 4Valeant Pharmaceuticals Submits HSR Filing Relating To Proposed Acquisition Of Allergan 5Pareto Biotechnologies Announces Technology Partnership With DNA2.0, Inc. 2Pareto Biotechnologies Announces Technology Partnership With DNA2.0, Inc. 3Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 2Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 3Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 4Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 5Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 6Abbott to Sell its Developed Markets Branded Generics Pharmaceuticals Business to Mylan 7
... /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NASDAQ: SVA ), ... it has filed its Annual Report on Form 20-F with ... December 31, 2010 on April 22, 2011.  The Annual Report ... The Company will provide a hard copy of ...
... The following release is being issued by law ... Feldman & Pinto: According to two new ... Medical Journal, Bayer,s birth control pills Yaz and Yasmin, ... triple the risk of serious blood clots (known as ...
Cached Medicine Technology:Sinovac Files Annual Report on Form 20-F 2
Sheath Introducers with guidewires....
... design, utilizing an advanced cobalt-based ... stainless steel stents. This stronger ... for unparalleled flexibility plus optimal ... Stent Systemwith thin struts that ...
... Catheter provides support to enhance the ... adverse conditions. It gives you dependable ... your destination in cardiac interventions. It ... of clinical situations and the most ...
... Xtra, and Maximum ACT introducers represent ... specialty hemostasis introducers in the world. ... hemostasis introducers for use in interventional ... angioplasty, stenting, atherectomy, temporary pacing, endomyocardial ...
Medicine Products: