Navigation Links
Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
Date:12/21/2011

PHILADELPHIA -- Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today.

Now, researchers from Thomas Jefferson University's Center for Translational Medicine have found that reducing levels of a well-known, cell-surface protein known as N-cadherin in those cancer cells can interfere with that activity. The disruption slowed down the pancreatic cancer cells' mobility, they found, and prolonged survival in mice.

The findings, published online in December in Nature's Oncogene, support a critical role for N-cadherin in pancreatic ductal adenocarcinma (PDA). Because this cancer does not typically produce symptoms until after it has metastasized, the mortality rate is very highits five-year survival rate is less than 5 percent. Thus, strategies that specifically target and prevent the spreading of the cancer cells have the potential to significantly improve the prognosis for patients.

"Previous studies demonstrated the importance of this cell surface protein for tumor cell growth," said Glenn Radice, Ph.D., an Associate Professor in the Department of Medicine at Jefferson's Center for Translational Medicine, and co-author of the study. "However, it was not clear from those studies whether interfering with N-cadherin levels would increase survival of animals genetically engineered to develop highly metastatic pancreatic cancer."

Using the mouse model, researchers found that reducing N-cadherin expression delayed tumor progression and prolonged survival in mice by 25 percent.

These studies implicate N-cadherin as a key regulator of multiple signaling pathways critical for cancer progression, a mechanism that can be exploited, the researchers point out.

This is another example of how researchers from the Center are bridging basic scientific discoveries with physicians' needs for their patientsby discovering and improving upon new targeted therapies for pancreatic cancer that may eventually be tested in clinical trials.

"Our survival results are very exciting because a drug, known as ADH-1, that specifically targets N-cadherin is already in clinical trial for melanoma" Dr. Radice said. "The next step is to test this N-cadherin-function blocking drug or a similar compound in the pancreatic cancer mouse model to see if it can prolong survival."


'/>"/>
Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the ... of funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... base and accelerate its technology and product roadmap. , “Jvion is ...
(Date:4/29/2016)... ... 2016 , ... CURE Media Group , the nation’s ... today announced that Lynne Malestic, RN, of Eisenhower Lucy Curci Cancer Center in ... Oncology Nursing , which honors nurses who have dedicated their careers to helping ...
(Date:4/29/2016)... ... April 29, 2016 , ... Natren, Inc. ... line of probiotics, Petbiotics ™, as they fondly call them. As animal ... groups networking for their non-profit organizations. Animal rescues across the nation face huge ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... raising awareness for Duchenne muscular dystrophy, and funding for Duchenne research, participated in ... efficacy of the Sarepta Therapeutic’s novel Duchenne drug eteplirsen. The meeting at the ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... 2014. Each year, reproductive endocrinologists are required to report in vitro fertilization ... of professionals dedicated to the practice of assisted reproductive technologies in the United ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... H1 2016" is a report that provides an ... strengthen R&D pipelines by identifying new targets and ... Company Profiles discussed in this H1 2016 ... Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., Ablynx ...
(Date:4/27/2016)... le 27 Avril 2016 ... progressé de +5% sur le trimestre, soutenu par ... consommables  Croissance de +16% des ventes ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : ... laser, annonce aujourd,hui son chiffre d,affaires pour le ...
(Date:4/27/2016)... 27, 2016 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... the global skincare devices market was valued at US$ ... at a CAGR of 10.1% from 2015 to 2023 ... Browse the full Skincare Devices Market (Treatment Device - LED ...
Breaking Medicine Technology: