Navigation Links
Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
Date:12/21/2011

PHILADELPHIA -- Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today.

Now, researchers from Thomas Jefferson University's Center for Translational Medicine have found that reducing levels of a well-known, cell-surface protein known as N-cadherin in those cancer cells can interfere with that activity. The disruption slowed down the pancreatic cancer cells' mobility, they found, and prolonged survival in mice.

The findings, published online in December in Nature's Oncogene, support a critical role for N-cadherin in pancreatic ductal adenocarcinma (PDA). Because this cancer does not typically produce symptoms until after it has metastasized, the mortality rate is very highits five-year survival rate is less than 5 percent. Thus, strategies that specifically target and prevent the spreading of the cancer cells have the potential to significantly improve the prognosis for patients.

"Previous studies demonstrated the importance of this cell surface protein for tumor cell growth," said Glenn Radice, Ph.D., an Associate Professor in the Department of Medicine at Jefferson's Center for Translational Medicine, and co-author of the study. "However, it was not clear from those studies whether interfering with N-cadherin levels would increase survival of animals genetically engineered to develop highly metastatic pancreatic cancer."

Using the mouse model, researchers found that reducing N-cadherin expression delayed tumor progression and prolonged survival in mice by 25 percent.

These studies implicate N-cadherin as a key regulator of multiple signaling pathways critic
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Living in a quality residential community means ... with it. A quality Home Owners Association like the ... available. , Simpson Mill Plantation, ... Association Management, LLC made a recent investment in a ... an additional amenity for their neighborhood. , Situated near ...
(Date:8/21/2014)... 21, 2014 Recently, Van Uden ... patients. Alternative medicine is on the rise and ... According to The Fiscal Times, young people are ... conventional medicine. , The Fiscal Times published an ... are embracing alternative medicine. The article can be ...
(Date:8/21/2014)... the coronary arteries of chronic kidney disease patients may ... to a new study in the Journal of ... Researchers at the Johns Hopkins Bloomberg School of Public ... used measures of subclinical atherosclerosis in predicting the risk ... Approximately 50 percent of all patients with chronic kidney ...
(Date:8/21/2014)... cancer appear to have better survival if they ... Author: Uchechukwu C. Megwalu, M.D., M.P.H., of the ... York, and colleagues. , Background: Approximately 11,000 to ... year and squamous cell carcinoma accounts for the ... total surgical removal of the larynx with postoperative ...
(Date:8/21/2014)... Improv performers from Fun House Theatre and Film ... Turtle Creek memory care community in Dallas. The Unicorn ... ages 10 to 16, delivers a groundbreaking and fun-filled ... troupe's philosophy is that improv is based on relationships, ... audiences regardless of their circumstance — including bringing joy ...
Breaking Medicine News(10 mins):Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Van Uden Center Sees Growth in Alternative Medicine 2Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Surgery associated with better survival for patients with advanced laryngeal cancer 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2
... Cant smell the roses? Maybe youre depressed. Smell too ... same problem. Scientists from Tel Aviv University recently linked ... glands. It might explain why some women, without realizing ... that supports this theory was published this year in ...
... developed a novel anti-tumor compound that represents a distinct strategy: ... cells. , The results of research on the compound in ... The article is highlighted on the cover. , The compound ... solid tumors in 2007. , The idea behind the intercept ...
... Study supports hormone therapy with radiation, finding no raised ... -- New research suggests that a common but controversial ... greatly boosting patients, risk of heart problems, as some ... cases of prostate cancer, a combination of testosterone-lowering drugs ...
... a Fresh, New Look, SAN JOSE, Calif., Jan. ... ) today announced the launch of a striking,new corporate ... logo. The,new logo elevates the profile of visionary JMSR ... that has worked with numerous national industry,brands., "When ...
... Fitness Professionals Predict Fun Focused Fitness, SAN ... Exercise,(ACE) has completed its annual survey of its ... advanced health and fitness,specialists and lifestyle and weight ... fitness industry. 2008 promises to be filled with,water ...
... 3 MedCath Corporation,(Nasdaq: MDTH ) announced that ... Annual JPMorgan Healthcare Conference held January,7 - 10, 2008 ... MedCath,s senior management will give its presentation on ... presentation will be,webcast live over the Internet via MedCath,s ...
Cached Medicine News:Health News:Why some depressed girls can't smell the roses 2Health News:Novel anticancer strategy moves from laboratory to clinic 2Health News:Novel anticancer strategy moves from laboratory to clinic 3Health News:Combo Therapy Cuts Prostate Cancer Death Rates 2Health News:Combo Therapy Cuts Prostate Cancer Death Rates 3Health News:Jan Marini Skin Research Gives Familiar Logo a Facelift 2Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 2Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 3Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 4
(Date:8/20/2014)... The National Association of Drug Diversion ... by the real-time, pseudoephedrine (PSE) blocking system in ... Exchange (NPLEx), automatically blocks unlawful pseudoephedrine sales and ... and make arrests. Data released by NPLEx shows ... blocked the sale of more than 7,481 boxes of ...
(Date:8/20/2014)... LUTHERVILLE, Md. , Aug. 20, 2014 /PRNewswire/ ... today lauded the latest results achieved by the ... known as the National Precursor Log Exchange (NPLEx), ... enforcement officials track down methamphetamine offenders and make ... in Michigan blocked the ...
(Date:8/20/2014)... , Aug. 20, 2014 ... research report is available in its ... Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html Given the ... (HAIs), demand has increased for solutions ...
Breaking Medicine Technology:Kansas's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6
BioSoft alcohol gel hand antiseptic with soothing moisturizers is a fast-acting, broad-spectrum antimicrobial solution. BioSoft alcohol gel hand antiseptic applies easily, requires no rinsing and dri...
... Scrub Care povidone-iodine (PVP-I) antimicrobial solutions ... control in all hospital and health-care settings. ... gel have a broad spectrum of activity, ... bacteria that may cause infection. The new ...
... hand sanitizers like Aplicare No Rinse Isopropyl ... as the recommended product for hand disinfection ... Guidelines for hand hygiene., According to the ... be prevented with better infection control programs. ...
This is long known for its purity and mildness, Castile Soap is also an effective cleaning agent that is used in a variety of applications. It rinses clean while leaving the skin soft and healthy....
Medicine Products: