Navigation Links
Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
Date:12/21/2011

PHILADELPHIA -- Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today.

Now, researchers from Thomas Jefferson University's Center for Translational Medicine have found that reducing levels of a well-known, cell-surface protein known as N-cadherin in those cancer cells can interfere with that activity. The disruption slowed down the pancreatic cancer cells' mobility, they found, and prolonged survival in mice.

The findings, published online in December in Nature's Oncogene, support a critical role for N-cadherin in pancreatic ductal adenocarcinma (PDA). Because this cancer does not typically produce symptoms until after it has metastasized, the mortality rate is very highits five-year survival rate is less than 5 percent. Thus, strategies that specifically target and prevent the spreading of the cancer cells have the potential to significantly improve the prognosis for patients.

"Previous studies demonstrated the importance of this cell surface protein for tumor cell growth," said Glenn Radice, Ph.D., an Associate Professor in the Department of Medicine at Jefferson's Center for Translational Medicine, and co-author of the study. "However, it was not clear from those studies whether interfering with N-cadherin levels would increase survival of animals genetically engineered to develop highly metastatic pancreatic cancer."

Using the mouse model, researchers found that reducing N-cadherin expression delayed tumor progression and prolonged survival in mice by 25 percent.

These studies implicate N-cadherin as a key regulator of multiple signaling pathways critic
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Arias, M.D., Ph.D., at The University of Texas Health ... superbug that caused a bloodstream infection in a Brazilian ... of The New England Journal of Medicine . ... of highly-resistant bacteria known as methicillin-resistant Staphylococcus aureus ... hospital and community-associated infections. The superbug has also acquired ...
(Date:4/17/2014)... The world is less than 40 years away from ... people and governments, according to a top scientist at ... time in human history, food production will be limited ... water and energy," said Dr. Fred Davies, senior science ... issues could become as politically destabilizing by 2050 as ...
(Date:4/17/2014)... its status as the leading weapon against the deadly ... with new research indicating it simply needs to be ... of the cheap anti-malarial drug chloroquine in treating and ... more than half a million people each year around ... developed resistance to chloroquine, but research carried out at ...
(Date:4/16/2014)... A team that includes scientists from the School of ... San Antonio, Johns Hopkins University and St. Mary,s University reported ... to infect the body. , The fungal pathogen Candida ... and is the most common fungal pathogen to infect humans. ...
(Date:4/15/2014)... , , CHAMPAIGN, Ill. Scientists have solved a decades-old medical mystery ... way to fight invasive fungal infections, which kill about 1.5 million ... of action of amphotericin, an antifungal drug that has been in ... nearly as toxic to human cells as it is to the ...
Breaking Medicine News(10 mins):Health News:New MRSA superbug emerges in Brazil 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:Scientists find new way to fight malaria drug resistance 2Health News:Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works 2Health News:Potent, puzzling and (now less) toxic: Team discovers how antifungal drug works 3
... physician and hospital is decreasing, study finds, , , TUESDAY, April ... physician would be the one who directed your health care ... comfort level. , But, in reality, that type of seamless ... Americans. , A new study found that among Medicare patients, ...
... pillow giveaway and Danny Seo appearance on HSN. , ... ... Earth Day, Simmons Bedding Company is encouraging consumers to ... the company,s Natural Care® mattress and pillow collection, which is endorsed ...
... RONKONKOMA, N.Y., April 21 NBTY, Inc. (NYSE: NTY ... marketer of nutritional supplements, today announced it will web cast a ... Web site, ( www.NBTY.com ), on Friday, April 24, ... for the fiscal second quarter will be issued at 4:30 PM ...
... CHAPEL HILL, N.C., April 21 New research with ... and managed markets is now available in the Best ... and consulting firm Best Practices, LLC.To review key topics ... links to each of the two new studies at ...
... WASHINGTON, April 21 FRC Action ... the Senate Finance Committee approved Gov. Kathleen Sebelius,s nomination ... vote on Gov. Sebelius,s nomination reflects growing grassroots opposition ... her failure to disclose deep financial ties to late-term ...
... Nursing baby brings cardiovascular benefits decades later, study suggests, ... just good for baby, it may also boost mom,s ... , Women in their 60s who had breast-fed for ... 10 percent less likely to develop cardiovascular disease, and ...
Cached Medicine News:Health News:Transition From Home to Hospital Rarely Seamless 2Health News:Transition From Home to Hospital Rarely Seamless 3Health News:Simmons Celebrates Earth Day by Encouraging Consumers To "Sleep Green" 2Health News:Simmons Celebrates Earth Day by Encouraging Consumers To "Sleep Green" 3Health News:Simmons Celebrates Earth Day by Encouraging Consumers To "Sleep Green" 4Health News:Simmons Celebrates Earth Day by Encouraging Consumers To "Sleep Green" 5Health News:NBTY to Web Cast Fiscal Second Quarter Conference Call 2Health News:NBTY to Web Cast Fiscal Second Quarter Conference Call 3Health News:Best Practice Database Adds Research Highlighting Effective Data Gathering Approaches for Competitive Intelligence and Successful Activities for Gaining Maximum Payer Access and Insights 2Health News:Breast-feeding a Boon to Mom's Heart 2Health News:Breast-feeding a Boon to Mom's Heart 3
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at ... is the first in Loudoun County to ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian ... Cole Taylor , are avid scuba divers. "As altitude skiers and ...
(Date:1/14/2014)... 14, 2014 Equashield ( http://www.equashield.com ... drugs, today announced that it has achieved 60% ...   Equashield,s closed systems reduce the ... and other medical professionals who prepare and administer ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... 6 The FDA has approved new technology that ... faster. The SonoCine Automated Whole-breast Ultrasound Method and is ... Arizona Breastnet, in Scottsdale. This unique technology is designed ... yearly mammography screening. Until now, ultrasound has only been ...
... , MARLTON, N.J., Dec. 4 Thermographic ... Center in Marlton, New Jersey continues to provide superior ... dental, TMJ and sinus regions to assist in the ... , Thermography utilizes infrared imaging cameras that "read" the ...
Cached Medicine Technology:New FDA Approved Breast Cancer Screening Tool 2New FDA Approved Breast Cancer Screening Tool 3Discover Health Through Awareness 2Discover Health Through Awareness 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: