Navigation Links
Researchers identify potential new strategy to treat ovarian cancer
Date:4/28/2014

Scientists studying cancerous tumour tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer which affects around 7,000 women in the UK each year.

Recently developed drugs have increased patient survival rates by targeting a tumour's blood vessels that supply essential nutrients and oxygen to cancer cells.

However, many patients go on to develop resistance to these therapies and grow new blood vessels that spread the cancer again.

A team from The University of Manchester part of the Manchester Cancer Research Centre - say blocking several avenues that tumour cells use to escape eradication at the same time is now the way forward rather than current drugs, which target only one molecule.

The research gives scientists the opportunity to develop new anticancer drugs that target ovarian tumour growth through the inhibition of the development of new tumour blood vessels.

Ovarian cancer is the deadliest of all gynaecological cancers, and since the majority of patients are diagnosed when the disease is at an advanced stage, prognosis is generally poor. Currently 7,000 women are diagnosed with the disease in the UK each year. Of those, more than 4,000 are not expected to survive but if women are diagnosed earlier 90% of those cases could beat the disease.

Scientists looked at the role of a particular set of molecules in controlling the activity of growth factors, proteins that are responsible for the stimulation of blood vessel growth.

Dr Egle Avizienyte, who co-led the research with Professor Gordon Jayson, said: "We know that a molecule called heparan sulphate (HS) is involved in blood vessel growth through facilitating interactions between the growth factors and their receptors that induce the development of new blood vessels. This is controlled by proteins known as HS6STs which regulate HS structure. By knocking down these proteins reducing their levels in cancer cells we were able
'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NYU Steinhardt researchers to study why male millennials risk HIV transmission
2. Researchers generate immunity against tumor vessel protein
3. Researchers at LSTM part of the international team to sequence the tsetse genome
4. Oxygen diminishes the hearts ability to regenerate, researchers discover
5. Finnish team of researchers finds a mutation in a tumor of the jaw
6. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
7. Life stressors trigger neurological disorders, researchers find
8. Penn researchers find link between sleep and immune function in fruit flies
9. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
10. CU researchers discover target for treating dengue fever
11. BUSM researchers find anti-seizure drug may reduce alcohol consumption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Steven Reinberg HealthDay Reporter ... fish oil supplements won,t prevent the return of a common ... report. In fact, 64.1 percent of those taking fish ... atrial fibrillation over the course of 16 months, compared to ... supplements also did not reduce the twin ills of inflammation ...
(Date:9/30/2014)... Francisco, California (PRWEB) September 30, 2014 ... expected to reach USD 38.75 billion by 2020 at ... according to a new study by Grand View Research, ... disorders due to lifestyle habits such as excessive alcohol ... in organ failure rates is expected to serve this ...
(Date:9/30/2014)... California (PRWEB) September 30, 2014 ... to reach USD 8,020.1 million by 2020, according ... Inc. Growing demand for personalized medicine and theranostics, ... technologies are expected to be key factors driving ... the growing global base of geriatric population and ...
(Date:9/30/2014)... AutoTex PINK proudly offers ... ribbon in support of breast cancer awareness and research ... and non-profits to “go pink” -- supporting walks, runs ... is a woman-owned company that is among the nation’s ... to partnering with their customers to raise breast cancer ...
(Date:9/30/2014)... MN (PRWEB) September 30, 2014 ... leader in business technology and services was recognized ... First Call Effectiveness (FCE) in 2013. This prestigious ... properly the first time and for an extended ... For more than 20 years BEI Services has ...
Breaking Medicine News(10 mins):Health News:Fish Oil Supplements Have Little Effect on Irregular Heartbeat: Study 2Health News:Fish Oil Supplements Have Little Effect on Irregular Heartbeat: Study 3Health News:Global Artificial Organ & Bionics Market Is Expecting Growth At CAGR Of 40.0% In Brain Bionics Segment From 2014 To 2020: Grand View Research, Inc. 2Health News:Global Artificial Organ & Bionics Market Is Expecting Growth At CAGR Of 40.0% In Brain Bionics Segment From 2014 To 2020: Grand View Research, Inc. 3Health News:Global Artificial Organ & Bionics Market Is Expecting Growth At CAGR Of 40.0% In Brain Bionics Segment From 2014 To 2020: Grand View Research, Inc. 4Health News:Global Artificial Organ & Bionics Market Is Expecting Growth At CAGR Of 40.0% In Brain Bionics Segment From 2014 To 2020: Grand View Research, Inc. 5Health News:Global Artificial Organ & Bionics Market Is Expecting Growth At CAGR Of 40.0% In Brain Bionics Segment From 2014 To 2020: Grand View Research, Inc. 6Health News:Global Molecular Diagnostics Market Is Expected To Be Worth $8,020.1 million by 2020: Grand View Research, Inc. 2Health News:Global Molecular Diagnostics Market Is Expected To Be Worth $8,020.1 million by 2020: Grand View Research, Inc. 3Health News:Global Molecular Diagnostics Market Is Expected To Be Worth $8,020.1 million by 2020: Grand View Research, Inc. 4Health News:Global Molecular Diagnostics Market Is Expected To Be Worth $8,020.1 million by 2020: Grand View Research, Inc. 5Health News:Global Molecular Diagnostics Market Is Expected To Be Worth $8,020.1 million by 2020: Grand View Research, Inc. 6Health News:Change Your Blades … Change A Life! AutoTex PINK Wiper Blades Are Helping Wipe Out Breast Cancer 2Health News:Change Your Blades … Change A Life! AutoTex PINK Wiper Blades Are Helping Wipe Out Breast Cancer 3Health News:Loffler Companies Rated Number One Among U.S. Dealers in Service “First Call Effectiveness” 2Health News:Loffler Companies Rated Number One Among U.S. Dealers in Service “First Call Effectiveness” 3
... ease a downsized employee,s healthcare and financial distress. , ... Nashville, Tenn. ... December 2007 - and more than 1.7 million in the last three ... loss of healthcare coverage and the unpredictable cost of medical care can ...
... Investors need a plan to deal with market stress, ... plan to deal with the stress of the market, ... at a recent gathering of the Greenwich Roundtable, a ... capital to alternative investments.Kiev, president of Kiev Consulting, coaches ...
... - With Photo , ... went,head-to-head to win a GBP2,000 investment from TV Dragon Duncan Bannatyne. ... toughest,challenge yet when they presented their big ideas on how they ... Shannon Stokes, 9, from Neith, South Wales, won with her proposal ...
... recruitment and career opportunities to address ongoing needs., , ... ... and as unemployment climbs, many healthcare fields are still stable or ... February, with a gain of 27,000. Job growth occurred in ambulatory ...
... Critical to Improving Quality of U.S. HealthcarePLANO, Texas, March ... ), the U.S. market leader for providing healthcare IT ... a second comprehensive webinar about the impact that the ... have on the U.S. Healthcare industry. The webinar ...
... Mental Illness (NAMI) Michigan released today the findings of its ... our state. The State of Michigan ... rating . Fourteen states improved their grades from 2006 and ... Michigan,s mental health care system has deteriorated even further this ...
Cached Medicine News:Health News:change:healthcare Helps Displaced Employees Immobilized by High Cost of Healthcare 2Health News:change:healthcare Helps Displaced Employees Immobilized by High Cost of Healthcare 3Health News:Psychiatrist and Trading Coach Dr. Ari Kiev Addresses Greenwich Roundtable 2Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 2Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 3Health News:"I'm In" - Duncan Bannatyne Judges "Switch Ash for Cash" Schools Competition 4Health News:Healthcare Industry Continues to Post Gains in a Down Economy 2Health News:Perot Systems Launches Webinar Series and Website Resources on Healthcare Stimulus Plan Provisions 2Health News:Perot Systems Launches Webinar Series and Website Resources on Healthcare Stimulus Plan Provisions 3Health News:Michigan's Mental Health Care System Gets a D Grade in Latest Study 2
(Date:9/29/2014)... DIEGO , 29 septembre 2014 ... (TSE : 4568) et Ambit Biosciences (NASDAQ : AMBI), ont ... fusion définitif en vertu duquel Daiichi Sankyo fera ... circulation d,Ambit Biosciences à 15 dollars par action ... d,achat qui sera suivie d,une fusion avec une ...
(Date:9/29/2014)... , Sept. 29, 2014 Pharmacists ... trials are conducted according to good clinical trials ... HOPA Investigational Drug Service Best Practice Standards, the ... practice standards and guidance for pharmacists and institutions ... Service Best Practice Standards emphasizes the critical role ...
(Date:9/29/2014)... Calif. , Sept. 29, 2014  Bob Pack, ... driver, today called on the California Medical Association to ... Proposition 46 that the San Jose Mercury News called ... "practically everything it wants voters to believe about the ... ad attacks the Prop 46 requirement that doctors check ...
Breaking Medicine Technology:Daiichi Sankyo va acquérir Ambit Biosciences 2Daiichi Sankyo va acquérir Ambit Biosciences 3Daiichi Sankyo va acquérir Ambit Biosciences 4Daiichi Sankyo va acquérir Ambit Biosciences 5Daiichi Sankyo va acquérir Ambit Biosciences 6Daiichi Sankyo va acquérir Ambit Biosciences 7Daiichi Sankyo va acquérir Ambit Biosciences 8Daiichi Sankyo va acquérir Ambit Biosciences 9HOPA Introduces First Investigational Drug Service Best Practice Standards For Institutions And Infusion Clinics 2HOPA Introduces First Investigational Drug Service Best Practice Standards For Institutions And Infusion Clinics 3Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 2Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 3Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 4Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: