Navigation Links
Researchers identify potential new strategy to treat ovarian cancer
Date:4/28/2014

Scientists studying cancerous tumour tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer which affects around 7,000 women in the UK each year.

Recently developed drugs have increased patient survival rates by targeting a tumour's blood vessels that supply essential nutrients and oxygen to cancer cells.

However, many patients go on to develop resistance to these therapies and grow new blood vessels that spread the cancer again.

A team from The University of Manchester part of the Manchester Cancer Research Centre - say blocking several avenues that tumour cells use to escape eradication at the same time is now the way forward rather than current drugs, which target only one molecule.

The research gives scientists the opportunity to develop new anticancer drugs that target ovarian tumour growth through the inhibition of the development of new tumour blood vessels.

Ovarian cancer is the deadliest of all gynaecological cancers, and since the majority of patients are diagnosed when the disease is at an advanced stage, prognosis is generally poor. Currently 7,000 women are diagnosed with the disease in the UK each year. Of those, more than 4,000 are not expected to survive but if women are diagnosed earlier 90% of those cases could beat the disease.

Scientists looked at the role of a particular set of molecules in controlling the activity of growth factors, proteins that are responsible for the stimulation of blood vessel growth.

Dr Egle Avizienyte, who co-led the research with Professor Gordon Jayson, said: "We know that a molecule called heparan sulphate (HS) is involved in blood vessel growth through facilitating interactions between the growth factors and their receptors that induce the development of new blood vessels. This is controlled by proteins known as HS6STs which regulate HS structure. By knocking down these proteins reducing their levels in cancer cells we were able to reduce activity of growth factors and stop ovarian cancer cells inducing the development of new blood vessels."

The studies in tumour tissue in the laboratory showed that reducing HS6STs led to a reduction of tumour growth.

Professor Gordon Jayson, who leads the research group, said: "This knowledge gives us the opportunity to develop new anticancer drugs aimed against these growth factors. Targeting multiple factors and blocking several avenues that tumour cells use to escape eradication at the same time may be a better strategy than current drugs, which target only one molecule."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. NYU Steinhardt researchers to study why male millennials risk HIV transmission
2. Researchers generate immunity against tumor vessel protein
3. Researchers at LSTM part of the international team to sequence the tsetse genome
4. Oxygen diminishes the hearts ability to regenerate, researchers discover
5. Finnish team of researchers finds a mutation in a tumor of the jaw
6. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
7. Life stressors trigger neurological disorders, researchers find
8. Penn researchers find link between sleep and immune function in fruit flies
9. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
10. CU researchers discover target for treating dengue fever
11. BUSM researchers find anti-seizure drug may reduce alcohol consumption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi ... be included in the 2016 “Guide to America’s Top Plastic Surgeons” for seven ... amalgamation of their education, experience, and professional associations. , One the most ...
(Date:12/2/2016)... OH (PRWEB) , ... December 02, 2016 , ... ... of veterinarian diagnostic imaging systems and the first company to offer ... With a Heart at their tradeshow booth # 941 for the American Association ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... today that it has raised $6.0 million in an initial round of funding. ... conviction that patients and their caregivers can receive far better care through the ...
(Date:11/30/2016)... Massachusetts (PRWEB) , ... November 30, 2016 , ... ... proud to announce that we have been designated as a Cigna Infertility Center ... or exceed rigorous performance standards. , “It’s an honor to be designated ...
(Date:11/30/2016)... Chino Hills, CA (PRWEB) , ... November 30, ... ... in eating disorder and mental health treatment has announced the opening of a ... specialized residential treatment for girls with mental health issues such as severe anxiety, ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... SPRING, Md. , Dec. 2, 2016 ... new indication for Jardiance (empagliflozin) to reduce the risk ... diabetes mellitus and cardiovascular disease. "Cardiovascular ... with type 2 diabetes mellitus," said Jean-Marc Guettier ... and Endocrinology Products in FDA,s Center for Drug Evaluation ...
(Date:12/2/2016)... , December 2, 2016 ... global cardiac pacemaker market in its upcoming report titled, "Global Market Study ... a Declining CAGR of -1.4% between 2016 and 2024". The ... Mn in 2015 and this is likely to decline ... revenue, the global cardiac pacemaker market is anticipated to ...
(Date:12/2/2016)... , December 2, 2016 According to ... "Global Market Study on Automated Endoscope Reprocessors: Single Basin Automated ... of 8.6% Between 2016 and 2024 " the global automated endoscope reprocessors ... expected to expand at a CAGR of 7.2% during an ... US$ 1,367.6 Mn by 2024. ...
Breaking Medicine Technology: