Navigation Links
Researchers identify potential new strategy to treat ovarian cancer
Date:4/28/2014

Scientists studying cancerous tumour tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer which affects around 7,000 women in the UK each year.

Recently developed drugs have increased patient survival rates by targeting a tumour's blood vessels that supply essential nutrients and oxygen to cancer cells.

However, many patients go on to develop resistance to these therapies and grow new blood vessels that spread the cancer again.

A team from The University of Manchester part of the Manchester Cancer Research Centre - say blocking several avenues that tumour cells use to escape eradication at the same time is now the way forward rather than current drugs, which target only one molecule.

The research gives scientists the opportunity to develop new anticancer drugs that target ovarian tumour growth through the inhibition of the development of new tumour blood vessels.

Ovarian cancer is the deadliest of all gynaecological cancers, and since the majority of patients are diagnosed when the disease is at an advanced stage, prognosis is generally poor. Currently 7,000 women are diagnosed with the disease in the UK each year. Of those, more than 4,000 are not expected to survive but if women are diagnosed earlier 90% of those cases could beat the disease.

Scientists looked at the role of a particular set of molecules in controlling the activity of growth factors, proteins that are responsible for the stimulation of blood vessel growth.

Dr Egle Avizienyte, who co-led the research with Professor Gordon Jayson, said: "We know that a molecule called heparan sulphate (HS) is involved in blood vessel growth through facilitating interactions between the growth factors and their receptors that induce the development of new blood vessels. This is controlled by proteins known as HS6STs which regulate HS structure. By knocking down these proteins reducing their levels in cancer cells we were able
'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NYU Steinhardt researchers to study why male millennials risk HIV transmission
2. Researchers generate immunity against tumor vessel protein
3. Researchers at LSTM part of the international team to sequence the tsetse genome
4. Oxygen diminishes the hearts ability to regenerate, researchers discover
5. Finnish team of researchers finds a mutation in a tumor of the jaw
6. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
7. Life stressors trigger neurological disorders, researchers find
8. Penn researchers find link between sleep and immune function in fruit flies
9. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
10. CU researchers discover target for treating dengue fever
11. BUSM researchers find anti-seizure drug may reduce alcohol consumption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... September 17, 2014 The Delta Dental ... to the National Children’s Oral Health Foundation: America’s ToothFairy ... NCOHF’s Orange County Oral Health Zone Program® in California. ... is engaging a range of local constituent groups and ... of severe tooth decay and its devastating effects on ...
(Date:9/17/2014)... News) -- Managing diabetes, quitting smoking, controlling high blood ... the risk for dementia -- even late in life, ... Report 2014, commissioned by Alzheimer,s Disease International, revealed that ... percent. The study noted that obesity and an inactive ... as high blood pressure. The researchers suggested ...
(Date:9/17/2014)... care system is not properly designed to meet the ... those of their families, and major changes to the ... Institute of Medicine. The 21-member committee that wrote ... integrates traditional medical care and social services and that ... for more "advance care planning" for end-of-life by individuals, ...
(Date:9/17/2014)... shown that most 18-month-olds learn an average of two ... known about how children process information to learn new ... a new study, a University of Missouri researcher has ... and a limit exists as to how many words ... parents enhance their children,s vocabularies and assist speech-language professionals ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 CarePoint Health ... when over 150 CarePoint Health employees participated in the ... the ALS Association. The event took place on ... Medical Center. CarePoint Health donated $100 to the ALS ... for a total of approximately $15,000. The Ice Bucket ...
Breaking Medicine News(10 mins):Health News:Delta Dental Community Care Foundation Donation to America's ToothFairy Helps Deliver Critical Services 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 2Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 4Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 5Health News:Babies learn words differently as they age, researcher finds 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 3
... study of young U.S. teens showed that between 11 ... an alcohol brand, and those who do appear more ... susceptibility, to beginning drinking, to binge drinking, according to ... of Pediatrics & Adolescent Medicine . , Alcohol-branded merchandise ...
... (Nasdaq: AIRM ) will report financial results for ... of the market on Tuesday, March 10, 2009. The ... 2009 at 4:15 p.m. Eastern to discuss these results. ... (domestic) or (706) 643-8826 (international) or by accessing the web ...
... surgery can restore function for obese males, study finds , , ... man, the greater his hormonal changes and the worse his ... side, the study,s authors found that gastric bypass surgery can ... obesity is correlated to lower sperm count and can be ...
... is best bet, experts say , , TUESDAY, March 3 ... find new solutions to combat the growing resistance to ... , "The startling news about oseltamivir [Tamiflu] resistance should ... effort to cope with this rapidly evolving pathogen," wrote ...
... second overall and first for long-term investment and social ... Diagnostics Incorporated (NYSE: DGX ), the world,s ... again been named to FORTUNE magazine,s list of the ... the "Health Care" category of "Pharmacy and Other Services." ...
... and CEO of the New Canadian EntityWHIPPANY, N.J., March ... company, has announced today that it is establishing a ... Ltd. This company will have its headquarters in Ontario, ... sale and distribution of branded pharmaceutical products currently available ...
Cached Medicine News:Health News:Owning alcohol-branded merchandise associated with teen drinking behaviors 2Health News:Men's Sex Lives May Suffer as Waistlines Expand 2Health News:Concerted Effort Needed to Fight Drug-Resistant Flu Strain 2Health News:Concerted Effort Needed to Fight Drug-Resistant Flu Strain 3Health News:Quest Diagnostics Again Named to FORTUNE Magazine's 'World's Most Admired Companies' List 2Health News:Halo Pharmaceutical Launches a Branded Product Marketing Company in Canada 2
(Date:9/17/2014)... OTEMR, Inc. , ONETOUCH EMR, 2.0 has achieved ONC ... the software is capable of supporting eligible providers with ... measures required to qualify for funding under the American ... certified on July 14, 2014 by ICSA Labs ... (ONC-ACB) and is compliant in accordance with applicable criteria ...
(Date:9/17/2014)... 17, 2014  Lightbeam Health Solutions announced today ... (Physician Direct ACO) to deploy the Lightbeam population ... better care while reducing costs. Photo ... Direct Accountable Care Organization is the ACO operating ... OPNS mission is to be the premier integrated ...
(Date:9/17/2014)... --  myMatrixx, a pharmacy and ancillary medical benefit manager for workers, ... has awarded myMatrixx with a "Best Places to Work ... row. Best Places to Work is ... Best Companies Group.  The competition, which involves months of ... insurance industry companies with at least 25 employees in ...
Breaking Medicine Technology:OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3myMatrixx Honored with "Best Places to Work in Insurance" Award 2
... Aug. 11, 2011 Lexicon Pharmaceuticals, Inc. ... on discovering breakthrough treatments for human disease, announced today ... president and chief executive officer, will present at the ... August 16, 2011 at 1:15 p.m. Eastern Time in ...
... Minn., Aug. 11, 2011 The City of St. Louis ... to help provide residents with some relief from the high ... the National League of Cities (NLC) – the City is ... discount cards offer city residents an average of 23 percent ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at the Wedbush 2011 Life Sciences Management Access Conference 2St. Louis Park and the National League of Cities Bring Free Prescription Discount Card Program to Residents 2
This CDI original designed Bra Vest incorporates Velcro® adjustable side closures to provide maximum compression to the patients breast, upper abdomen, upper and lower back....
Female Mini-VEST Seamless, Front Closure...
Male Support Brief...
For Lipoplasty or surgery of abdomen, flanks and midriff...
Medicine Products: