Navigation Links
Researchers identify potential new avenue to attack cancer
Date:8/12/2009

EAST LANSING, Mich. New insight into how human cells reproduce, published by cancer researchers at Michigan State University and the Van Andel Research Institute in Grand Rapids, could help scientists move closer to finding an "off switch" for cancer.

Cancer cells divide uncontrollably and can move from one part of the body to another. They undergo dramatic shifts in shape when they do so, said Aaron DeWard, an MSU cell and molecular biology doctoral candidate who published his research recently in the Journal of Biological Chemistry. He's trying to figure out how certain proteins trigger cell movement and division and how cancer hijacks the system to create genomic instability.

DeWard and his academic adviser, VARI senior scientific investigator Art Alberts, investigated proteins called formins that help determine the shape of a cell during division and movement. They identified a new mechanism for regulation of formins during cell division.

"One of the cool things about these proteins is that they're tightly regulated they will only do their jobs when they're told to do so," DeWard said, describing formins as the workers that put together the pieces that shape a cell.

"A lot of work has been done on how to get these proteins to work, but not when to stop working," he said. "We identified the way in which these proteins get flagged for destruction. This mechanism is pretty common for a lot of proteins, but had never been shown for this family of proteins before, and no one really knew how to shut them off completely."

The family of proteins DeWard and Alberts are studying could lend themselves well to pharmaceutical treatment, he added.

"Aaron's observation gives us a handle on the molecular machinery controlling cell division," Alberts said. "Our goal now is to exploit this information in the development of strategies to specifically stop the process of uncontrolled cell division that characterizes cancer."

"I don't think shutting them off will stop cancer, but by better understanding the mechanism of this we might find ways to manipulate the system," DeWard said.

The MSU-VARI connection constitutes a vibrant, research-oriented dimension to the university's growing presence in the western Michigan health care complex. Michigan State opens its new College of Human Medicine building, the Secchia Center, in downtown Grand Rapids near VARI parent Van Andel Institute, Spectrum Health and other health care organizations in 2010. It signed a research collaboration agreement with the VAI in 2006.

"Collaboration is essential to developing West Michigan as a center for life sciences," said Steve Heacock, VAI chief administrative officer and general counsel. "A solid connection and interaction between students, scientists, medical professionals and the entire life science community is vital. We have a strong collaboration. MSU students work in VAI laboratories, MSU and VAI researchers collaborate on studies and there will be a two-way connection between VAI and the new MSU College of Human Medicine."

A joint graduate school program allows graduate students in several medicine-related programs to take one of their laboratory "rotations" at VARI, and afterward to complete their thesis project there. Four VARI fellowships also are awarded to MSU first-year graduate students interested in cancer research or cell biology.


'/>"/>
Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify potential new avenue to attack cancer
(Date:1/21/2017)... ... January 21, 2017 , ... The ... Dr. Dan Holtzclaw in media for its creos™ line of bone regenerative products. ... Dr. Holtzclaw in which he utilizes creos™ allo.gain™ bone graft for a variety ...
(Date:1/20/2017)... ... ... Pastor and Overseer at The House of Yahweh has posted a new publication this week ... is a time like no other and society needs to understand the only way to ... not want to sound like an old bible beater because religion has a bad rap ...
(Date:1/20/2017)... ... January 20, 2017 , ... Bionic Sports Nutrition LLC, an American ... announced it had a successful January ECRM Trade Show in Hilton Head, SC. ... which allows it to provide its products to all clients at reasonable prices. At ...
(Date:1/20/2017)... ... January 20, 2017 , ... International Protein, a company ... bodybuilding supplements, announced it attended the January ECRM trade show in Hilton Head, SC. ... scientist who was determined to create a line of products that would elevate her ...
(Date:1/20/2017)... ... 20, 2017 , ... Vitamin Well has launched two new ... have been produced in collaboration with Zlatan Ibrahimovic and have been developed to ... a successful launch in Sweden last year, the next generation sports drinks VW+001 ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... Research and Markets has announced the addition of the ... (Tumor, Clinical Chemistry, Microbiology, Esoteric), By Type of Lab (Hospital, ... HIV/AIDS etc.), Forecast to 2022" report to their offering. ... US ... clinical lab testing, which has evolved as a major source ...
(Date:1/21/2017)... Research and Markets has announced the addition ... Technology, Route Of Administration, End User - Forecast to 2025" ... ... at a CAGR of around 7.8% over the next decade to ... report analyzes the global markets for Advanced Drug Delivery across all ...
(Date:1/20/2017)... YORK , January 20, 2017 ... Inc. (NASDAQ: SGYP ), Novo Nordisk A/S (NYSE: ... SCMP ), and Pernix Therapeutics Holdings Inc. (NASDAQ: ... fell on Thursday, January 19 th , 2017, finishing near ... Health Care Index dropped over 0.7%, while shares of health ...
Breaking Medicine Technology: