Navigation Links
Researchers identify potential molecular target to prevent growth of cancer cells
Date:9/16/2011

GALVESTON, September 16, 2011 Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of Texas Medical Branch may lead to treatments for a range of cancers and atherosclerosis, which p53 also helps prevent, and appears in the current print issue of the Journal of Biological Chemistry.

"The p53 protein is a critical defense against cancer because it activates genes that induce apoptosis, or the death of cells. However, p53 can be made powerless by mutations and inhibitors like fortilin," said Dr. Ken Fujise, lead author of the study and director, Division of Cardiology at UTMB.

Fortilin, an amino acid polypeptide protein, works in direct opposition to p53, protecting cells from apoptosis. Fujise discovered fortilin in 2000 and the protein has become a central focus of his research. This study marks the first time that scientists have been able to show the exact mechanism whereby fortilin exerts its anti-apoptotic activity.

Fujise and his team used cell cultures and animal models to show that fortilin binds to and inhibits p53, preventing it from activating genes, such as BAX and Noxa, that facilitate cell death. Thus, cells that would be killed are allowed to proliferate.

"When normal cells become cancer cells, our bodies' natural biological response is to activate p53, which eliminates the hopelessly damaged cells," said Fujise. "This process explains why the majority of people are able to stay cancer-free for most of their lives. Conversely, mutated p53 genes are seen in more than half of all human cancers, making them the most frequently observed genetic abnormality in cancer."

According to Fujise, upon further research and validation of the biological mechanism described in this study, scientists can begin exploring compounds that could modulate fortilin's activity on p53.

Such a compound would be a powerful chemotherapy agent and, because p53 inhibition has also been associated with atherosclerosis, could also protect against coronary disease and its many complications, including heart attack and stroke.

"Though we are in the early stages of this research, once screening for compounds is initiated, we could have a potential new drug to investigate in a very short period of time," said Fujise. With the support of National Institutes of Health high-throughput screening programs, which make it possible to screen very large numbers of compounds against a drug target, the process of identifying a new drug could potentially be shortened to months rather than years, he added.

Other authors include scientists at UTMB and other institutions: Yanjie Chen, Takayuki Fujita, Di Zhang, Hung Doan, Decha Pinkaew, Zhihe Liu, Jiaxin Wu, Yuichi Koide, Andrew Chiu, Curtis Chen Jun Lin, Jui-Yoa Chang; and Ke-He Ruan.

The study was supported in part by the National Institutes of Health, the American Heart Association, and MacDonald General Research Fund.


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-789-4940
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
2. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
3. $1.1 million grant targets disparities among medical researchers
4. Yale researchers use uterine stem cells to treat diabetes
5. Clemson researchers using interactive vision tool for driving studies
6. Researchers utilize neuroimaging to show how brain uses objects to recognize scenes
7. Researchers focus on secondary stroke prevention after study reveals room for improvement
8. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
9. Researchers find process that clears cholesterol and could reverse major cause of heart attack
10. Aerobic exercise may reduce the risk of dementia, Mayo Clinic researchers say
11. MU researchers use new video gaming technology to detect illness, prevent falls in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... Metabolic ... supplement GlycoLoad at this week’s 2016 Europa Games Get Fit and Sports Expo ... consumers alike, the Europa Orlando Expo coming up April 29-30, was selected as the ...
(Date:4/28/2016)... ... ... The Aging in Motion Coalition (AIM) has announced the Centers for ... recognition for separate reporting and data collection. The code, M62.84, will be available for ... a combination of low muscle mass and weakness in older adults that causes functional ...
(Date:4/28/2016)... ... April 28, 2016 , ... Prescription ... co-operative bankruptcy to receive their prescription medications through America’s fastest-growing pharmacy program. ... medications from over 180 American pharmaceutical companies for $35 per month, per ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... latest offering, the Protocol Calendar Exchange , is officially open to all ... protocol calendars available for sites to download into their clinical trial management system ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Medical Officer at the Steadman Philippon Research Institute in Vail, Colorado, attended the ... raise awareness about the debilitating and costly musculoskeletal disorders that are affecting millions ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... insights on healthcare, announced today that it has been ... Cool Vendor in Life Sciences, 2016, ... 2016.  The report focuses on life-science- oriented analytics, algorithms ... from patients and doctors, confirm medication ingestion, and analyze ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
(Date:4/27/2016)... 27 Avril 2016   ... de +5% sur le trimestre, soutenu par une ... Croissance de +16% des ventes aux ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), ... annonce aujourd,hui son chiffre d,affaires pour le premier ...
Breaking Medicine Technology: