Navigation Links
Researchers identify potential molecular target to prevent growth of cancer cells
Date:9/16/2011

GALVESTON, September 16, 2011 Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of Texas Medical Branch may lead to treatments for a range of cancers and atherosclerosis, which p53 also helps prevent, and appears in the current print issue of the Journal of Biological Chemistry.

"The p53 protein is a critical defense against cancer because it activates genes that induce apoptosis, or the death of cells. However, p53 can be made powerless by mutations and inhibitors like fortilin," said Dr. Ken Fujise, lead author of the study and director, Division of Cardiology at UTMB.

Fortilin, an amino acid polypeptide protein, works in direct opposition to p53, protecting cells from apoptosis. Fujise discovered fortilin in 2000 and the protein has become a central focus of his research. This study marks the first time that scientists have been able to show the exact mechanism whereby fortilin exerts its anti-apoptotic activity.

Fujise and his team used cell cultures and animal models to show that fortilin binds to and inhibits p53, preventing it from activating genes, such as BAX and Noxa, that facilitate cell death. Thus, cells that would be killed are allowed to proliferate.

"When normal cells become cancer cells, our bodies' natural biological response is to activate p53, which eliminates the hopelessly damaged cells," said Fujise. "This process explains why the majority of people are able to stay cancer-free for most of their lives. Conversely, mutated p53 genes are seen in more than half of all human cancers, making them the most frequently observed genetic abnormality in cancer."

According to Fujise, upon further research and validation of the biological mechanism described in this study, scientists can begin exploring compounds that could modulate fortilin's activity on p53.

Such a compound would be a powerful chemotherapy agent and, because p53 inhibition has also been associated with atherosclerosis, could also protect against coronary disease and its many complications, including heart attack and stroke.

"Though we are in the early stages of this research, once screening for compounds is initiated, we could have a potential new drug to investigate in a very short period of time," said Fujise. With the support of National Institutes of Health high-throughput screening programs, which make it possible to screen very large numbers of compounds against a drug target, the process of identifying a new drug could potentially be shortened to months rather than years, he added.

Other authors include scientists at UTMB and other institutions: Yanjie Chen, Takayuki Fujita, Di Zhang, Hung Doan, Decha Pinkaew, Zhihe Liu, Jiaxin Wu, Yuichi Koide, Andrew Chiu, Curtis Chen Jun Lin, Jui-Yoa Chang; and Ke-He Ruan.

The study was supported in part by the National Institutes of Health, the American Heart Association, and MacDonald General Research Fund.


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-789-4940
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
2. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
3. $1.1 million grant targets disparities among medical researchers
4. Yale researchers use uterine stem cells to treat diabetes
5. Clemson researchers using interactive vision tool for driving studies
6. Researchers utilize neuroimaging to show how brain uses objects to recognize scenes
7. Researchers focus on secondary stroke prevention after study reveals room for improvement
8. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
9. Researchers find process that clears cholesterol and could reverse major cause of heart attack
10. Aerobic exercise may reduce the risk of dementia, Mayo Clinic researchers say
11. MU researchers use new video gaming technology to detect illness, prevent falls in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2016)... Aliso Viejo, California (PRWEB) , ... December 10, 2016 , ... ... editors to create dozens of unique animations," said Christina Austin - CEO of Pixel ... created exclusively for use within FCPX . This set of versatile transitions ...
(Date:12/10/2016)... ... December 10, 2016 , ... When faced with having ... germs spreading from the seat to her body, and contamination of children when they ... way to solve this problem that many people face. , The patent-pending SANI-POCKET enables ...
(Date:12/9/2016)... ... December 09, 2016 , ... Cellairis is a worldwide mobile device and ... iPhone , iPad and Samsung Galaxy devices with premium parts and accessories. ... to maximize convenience and accessibility for customers. While customers do their shopping, Cellairis can ...
(Date:12/9/2016)... ... December 09, 2016 , ... The Justin Veatch Fund ... (NCADD) is recommending the film Whispering Spirits and its discussion guide ... Columbia as an education tool in the war against teen drug abuse. NCADD ...
(Date:12/9/2016)... NY (PRWEB) , ... December 09, 2016 , ... Mediaplanet ... awareness for organ transplantation while encouraging readers to sign up as an organ donor ... lifesaving organ transplant. , An organ donor can save up to 8 saves ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Dec. 9, 2016   Hudes Laser Aesthetica ... featuring the multi-wavelength Astanza Trinity laser and Astanza ... in laser tattoo removal, IPL hair removal, pigmented ... therapy. Hudes Laser Aesthetica is setting high standards ... and promises to deliver effective, long-lasting results. ...
(Date:12/9/2016)... , Dec 9, 2016 Research ... Transceiver Market 2016-2020" report to their offering. ... The report forecasts the global ... the period 2016-2020. The report covers the present ... for 2016-2020. To calculate the market size, the report considers the ...
(Date:12/9/2016)... 2016  Harmar Mobility, LLC announced today that Steven E. Dawson has ... Board of Directors. Photo - http://photos.prnewswire.com/prnh/20161209/447552 ... Harmar ... Mr. Dawson,s executive career includes leadership roles ... variety of industries. He brings to the company deep operational and leadership ...
Breaking Medicine Technology: