Navigation Links
Researchers identify potential gene that may increase risk of ad in African Americans
Date:8/4/2014

(Boston)-- Researchers from Boston University School of Medicine (BUSM) report that two rare variants in the AKAP9 gene significantly increase the risk of Alzheimer's disease (AD) in African-Americans.

This previously unknown association furthers the understanding of the role of genetic factors in the development of AD, according to the researchers, whose findings appear in Alzheimer's & Dementia.

AD is the most frequent age-related dementia affecting 5.4 million Americans including 13 percent of people age 65 and older and more than 40 percent of people age 85 and older. Up to 75 percent of AD cases are thought to have a genetic basis; however the specific genes involved likely differ between ethnic populations. The most well-known AD risk gene, APOE4, does not play as strong a role in AD risk in African Americans as it does in Caucasians, despite the fact that a higher proportion of African Americans than Caucasians are afflicted with this disorder.

By analyzing the DNA sequence for all genes from participants of the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study and Genetic and Environmental Risk Factors for Alzheimer's Disease among African Americans (GenerAAtions) Study, researchers identified two genetic variants in AKAP9 unique to African Americans that are enriched in individuals with AD. They then confirmed this association in several thousand other African American subjects in the Alzheimer Disease Genetics Consortium dataset. Carriers of either of these AKAP9 variants have a respective 2.8 and 3.6 times greater risk of developing AD.

According to the researchers AKAP9 encodes a protein with multiple forms, One of these, AKAP450, is expressed in the brain and responsible for microtubule anchoring and organization. Another protein, tau, which is responsible for microtubule functioning is well known to be the key constituent of neurofibrillary tangles that accumulate in AD brains. "While further work is needed to clarify the causal link between these AKAP9 variants and AD, "this study indicates a new potential disease mechanism in the quest for a better understanding of AD, particularly in African Americans," explained senior author Lindsay Farrer, PhD, Chief of Biomedical Genetics and professor of medicine, neurology, ophthalmology, epidemiology and biostatistics at BUSM. "Moreover, this is the first authentic example of rare genetic variants conferring a high risk of AD in African Americans," he added.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers develop food safety social media guide
2. WSU researchers see violent era in ancient Southwest
3. Rare developmental disorder linked to tumor-suppressing protein, Stanford researchers find
4. NYU CDUHR researchers look at prescription opioid abuse among young adults in NYC
5. Researchers uncover cause of gum disease related to type 2 diabetes
6. U-M researchers find protein that fuels repair of treatment-resistant cancer cells
7. Neuro researchers advocate for a shift in thinking for stroke rehabilitation
8. Penn researchers: Naltrexone may diminish impulse control disorders in Parkinsons disease patients
9. Brazilian researchers identify RNA that regulates cell death
10. Researchers take steps toward development of a vaccine against tick-transmitted disease
11. UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... , ... January 24, 2017 , ... ... Ph.D., http://www.faculty.washington.edu/ghp , Sharon Kleyne, the nation’s foremost water advocate and ... Climate Change and Your Health on Voice America, once again welcomed one of ...
(Date:1/24/2017)... ... January 24, 2017 , ... A yellow fever outbreak in Brazil has infected ... fever is primarily spread through contact with infected mosquitos. The outbreak has sparked increased ... its spread. , According to multiple health organizations, the best way to prevent yellow ...
(Date:1/24/2017)... ... 24, 2017 , ... “Choosing Wisdom-Solomon’s Proverbs Reclaimed”: an ... gossip, prostitution, adultery, anger, and common sense. , “Choosing Wisdom-Solomon’s Proverbs Reclaimed” ... David Coats. In September of 1983, they flew to Haiti to focus on ...
(Date:1/24/2017)... ... , ... “Mysteries Revealed On Speaking In Tongues”: an engaging and dynamic ... Christians. “Mysteries Revealed On Speaking In Tongues” is the creation of published author, Tina ... located in Michigan. , “We need to partner with Jesus and be the ...
(Date:1/24/2017)... Milford, PA (PRWEB) , ... January 24, 2017 ... ... want breast implants, a new scientific article suggests that autologous fat ... procedure for achieving larger breasts naturally, without breast implants. , Cosmetic Surgeon ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , January 24, 2017 The global  active pharmaceutical ... billion by 2025, based on a new report by Grand View Research, ... projected to drive the market over the forecast period. Advancements in recombinant ... estimated to boost growth.  Continue Reading ... ...
(Date:1/24/2017)... YORK , Jan. 23, 2017 ... detect, and control light. The interaction of these ... used in a wide range of applications. These ... aerospace and defense, telecommunications, and healthcare among others. ... primarily owing to its low power consumption, reliability, ...
(Date:1/24/2017)... , Jan. 23, 2017 The global peripheral ... 2015, and it is expected to grow at a ... catheter segment accounted for larger share in the global ... the various end users, the hospital segment accounted for ... same year. The global peripheral I.V. catheter market is ...
Breaking Medicine Technology: