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Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
Date:1/19/2014

o years, participants receive questionnaires that ask about diseases and health-related topics like smoking, physical activity, and medications taken. Questionnaires that ask detailed dietary information are administered every four years.

Van Blarigan and colleagues investigated whether prediagnostic physical activity was associated with prostate tumor blood vessel regularity among 572 men enrolled in the Health Professionals Follow-up Study. Prediagnostic physical activity was determined through analysis of questionnaire answers. Blood vessel regularity was established by semiautomated image analysis of the tumor samples. Blood vessels that are perfect circles are considered the ideal shape and given a score of 1. Higher values indicate less regular blood vessels.

The researchers found that men with the fastest walking pace (3.3𔃂.5 miles per hour) prior to diagnosis had 8 percent more regularly shaped blood vessels compared with men with the slowest walking pace (1.5𔃀.5 miles per hour).

"Our study, which provides a potential explanation by which exercise may improve outcomes in men with prostate cancer, highlights the value of multidisciplinary collaborations between laboratory, clinical, and population scientists to explore new pathways by which lifestyle factors or other exposures may affect disease," said Van Blarigan. "It is reasonable to hypothesize that the same explanation could exist for the beneficial effects of exercise in other cancers, and it would be interesting to examine this in future studies."


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Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

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