Navigation Links
Researchers identify phthalates in numeruous medicines and supplements

(Boston) Researchers from Boston University's Slone Epidemiology Center (SEC), in collaboration with Harvard School of Public Health, have found numerous prescription and over-the-counter drugs and supplements use certain chemicals called phthalates as inactive ingredients in their products. The findings appear on-line in Environmental Health Perspectives.

Phthalates such as dibutyl phthalate (DBP) and diethyl phthalate (DEP) are used as inactive ingredients in FDA-approved medications where they may serve a variety of functions. Most commonly, they are used in the coating of a drug product to target the delivery of the active ingredients to a specific area of the gastrointestinal tract, or manage their release over time. Some phthalates, including DBP have been identified as causing adverse developmental and reproductive effects in laboratory animals. Limited human studies have suggested a possible association of DBP and DEP with male reproductive health outcomes.

Using a combination of resources, the researchers were able to identify over 100 drug and dietary supplement products that indicated they contained phthalates, including 50 prescription, 40 over-the-counter (OTC) and 26 dietary supplement products with labels that listed DEP or DBP, of which nine contained DBP. In addition, a large number of product labels listed phthalate polymers that are considered to be of little or no known toxicity but which are often used in combination with other phthalates.

"Given the thousands of orally-ingested products on the market (prescription, OTC and dietary supplements), it is difficult to know exactly how many contain phthalates. However, it is informative and important to identify the specific drug products that have included phthalates in their formulations," said lead author Kathy Kelley, MPH, RPh, a research pharmacist at BU's SEC.

According to the researchers, the potential health effects of human exposure to these phthalates through medications are unknown and warrant further investigation. "The present findings should assist researchers in conducting the necessary studies of potential risk of phthalates in human populations, but such efforts are limited by the lack of centralized, comprehensive, and publically-available information on the presence of phthalates in the full range of prescription, OTC and dietary supplement products," added Kelley.

The researchers recommend that future studies should pay particular attention to the amount of phthalate, specifically DBP, used in each dosage form so that estimates of exposure from medications and supplements can be quantified.


Contact: Gina DiGravio
Boston University Medical Center

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
Breaking Medicine Technology: