Navigation Links
Researchers identify novel genetic markers linked to increased risk of heart attack
Date:2/17/2009

A key finding is that the MI risk is more than twice as great in individuals who carry not only one but several of the genetic markers. Three studies on genetic markers and MI risk have now been published in the current online issue of the renowned journal Nature Genetics.

In a large-scale study coordinated by the University of Lbeck, German, European and American researchers succeeded in identifying novel genetic markers associated with MI. Two institutes of Helmholtz Zentrum Mnchen the Institute of Epidemiology (director: Prof. Dr. Dr. H. Erich Wichmann) and the Institute of Human Genetics (director: Prof. Dr. Thomas Meitinger) - were also involved in the study. The scientists performed a genome-wide scan of thousands of patients with hundreds of thousands of genetic markers. Included in the studies were MI patients from the KORA study (director: Dr. Christine Meisinger) as well as healthy control persons from the population.

"The future challenge for us will be to integrate the insights we have gained about genetic factors and lifestyle factors in order to provide effective preventive measures for the population," said Prof. Dr. Annette Peters, research group leader at Helmholtz Zentrum Mnchen.

The first of the three studies investigated a million genetic markers in 1,200 MI patients and the same number of healthy test persons. Subsequent control studies on an additional 25,000 patients and healthy persons confirmed the initial suspicion: Culprit genes for MI are located on chromosomes 3 and 12. Scientists suspect that one of these genes, the MRAS gene, plays an important role in cardiovascular biology. The second gene, the HNF1A gene, is closely associated with cholesterol metabolism.

What is special about the second study is that it not only investigated individual genetic markers as to their influence on the risk of myocardial infarction, but also investigated haplotypes, combinations of up to ten neighboring markers. With this method additional genetic information can be derived compared to individual genetic markers. Thus the scientists were able to identify another region, this time localized on chromosome 6, which is associated with MI risk. The LPA gene at this locus regulates the concentration of a specific lipoprotein (Lp(a)), a particle which transports lipids in the blood. This finding, too, may be useful in the future for developing new therapeutic interventions.

The third study, published in the name of the Myocardial Infarction Genetics Consortium (MIGen), was able to identify three further, previously unknown MI genes on chromosomes 2, 6 and 21. The study also shows that in individuals with not just one but several genetic markers, the MI risk is more than double. The higher the number of disease genes now identified, the higher the disease risk. This knowledge will aid in assessing the risk for myocardial infarction in order to develop preventive and early intervention strategies.

More than 750,000 people die of myocardial infarction in Europe every year. MI and the underlying coronary artery disease are among the most frequent causes of death in Germany. Besides traditional risk factors such as age, hypertension, disorders of the lipid metabolism, diabetes mellitus, smoking and overweight, genetic risk factors play a key role in the emergence of the disease.

These studies provide crucial pieces to the at present incomplete puzzle of myocardial infarction genetics. The findings indicate that there may be many mechanisms involved in myocardial infarction that are still to be discovered. New mechanisms also mean new approaches for MI prevention and treatment. Further studies are needed to elucidate this in detail.


'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-893-187-3946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
Breaking Medicine Technology: