Navigation Links
Researchers identify novel approach to create red blood cells, platelets in vitro
Date:5/30/2013

(Boston) A study led by Boston University School of Medicine has identified a novel approach to create an unlimited number of human red blood cells and platelets in vitro. In collaboration with Boston University School of Public Health (BUSPH) and Boston Medical Center (BMC), the researchers differentiated induced pluripotent stem (iPS) cells into these cell types, which are typically obtained through blood donations. This finding could potentially reduce the need for blood donations to treat patients requiring blood transfusions and could help researchers examine novel therapeutic targets to treat a variety of diseases, including sickle cell disease.

Published online in the journal Blood, the study was led by George J. Murphy, PhD, assistant professor of medicine at BUSM and co-director of the Center for Regenerative Medicine (CReM) at Boston University and BMC and performed in collaboration with David Sherr, PhD, a professor in environmental health at BUSM and BUSPH.

iPS cells are derived by reprogramming adult cells into a primitive stem cell state that are capable of differentiating into different types of cells. iPS cells can be generated from mature somatic cells, such as skin or blood cells, allowing for the development of patient-specific cells and tissues that should not elicit inappropriate immune responses, making them a powerful tool for biological research and a resource for regenerative medicine.

In this study, the iPS cells were obtained from the CReM iPS Cell Bank. The cells were exposed to growth factors in order to coax them to differentiate into red blood cells and platelets using a patented technology. These stem cells were examined in depth to study how blood cells form in order to further the understanding of how this process is regulated in the body.

In their new approach, the team added compounds that modulate the aryl hydrocarbon receptor (AhR) pathway. Previous research has shown th
'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers shed new light on egg freezing success rates
2. Junk DNA plays active role in cancer progression, researchers find
3. Researchers provide rationale for use of targeted immunotherapy in sarcomatoid lung carcinomas
4. Stanford researchers identify genetic suspects in sporadic Lou Gehrigs disease
5. Researchers identify first drug targets in childhood genetic tumor disorder
6. Researchers find common childhood asthma unconnected to allergens or inflammation
7. Researchers identify networks of neurons in the brain that are disrupted in psychiatric disease
8. Fish Oil Pills Might Cut Diabetes Risk, Researchers Say
9. Researchers find genetic risk factor for pulmonary fibrosis
10. Researchers find genetic tie to improved survival time for pulmonary fibrosis
11. Leading researchers report on the elusive search for biomarkers in Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... Having been working in the garment industry ... customer needs. According to James, one of the company’s top ... or with high-low skirts that add beauty to them. Chiffon ... LunaDress has unveiled its new selection of 2014 long prom ... brand new items are available in over 20 popular designs. ...
(Date:10/19/2014)... Recently, Fancyflyingfox.com, an innovative company that provides many kinds ... designs of 2014 mother of the bride dresses ... offered with big discounts, up to 70% off. All ... enjoy this special offer. , Owing to the ... one of the leading brands in the global market. ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 Visual ... program has just been released to the public ... online body building and fitness community. The commotion ... of DietsAndFitnessGuides.com's Vin Delmonico prompting an investigative review. ... of hitting what is commonly known as a ...
(Date:10/19/2014)... News) -- New stem cell-based research could improve understanding ... a new study suggests. Scientists used stem cells ... a lab dish. They then transplanted the organoids into ... according to the researchers. "This provides a new ... can cause intestinal failure, from genetic disorders appearing at ...
(Date:10/19/2014)... CHICAGO, OCTOBER 20, 2014 – The U.S. Government ... effectively treat Alzheimer,s disease by 2025. However, a ... says the research milestones in the U.S. Government,s ... broadened in scope, increased in scale, and adequately ... A series of proposals by the workgroup to ...
Breaking Medicine News(10 mins):Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2Health News:Scientists Grow, Implant Human Intestinal Tissue in Mice 2Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 2Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 3Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 4Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 5Health News:Scientists say national Alzheimer's plan milestones must be strengthened to meet goal by 2025 6
... on the Indian front has run into rough weather ... Parke-Davis (India). A local court in Hyderabad has ... city. ,The vacation court of the Ranga Reddy ... machinery of Parke-Davis (India) following a petition filed by ...
... has found a new treatment - Vedic vibration technology. ... Vedic Vibration Technology in subjects with arthritis,' revealed that scientists ... in 36 per cent of the patients treated and at ... cent cases. ,The study was recently conducted in Berlin ...
... certain cancers, hepatitis and multiple sclerosis with interferon therapy ... can seriously spoil its quality. Alpha interferon a ... depression. ,A new research now shows that the ... avoid this problem. Almost 50% of people on ...
... Bank, whose website (www.worldbank.org) declares "Our dream is a ... private hospital in Mumbai, India, a move which some ... assistance for projects that will mainly benefit the rich. ... state an International Development Association loan of $134m (89m), ...
... says that women with low risk pregnancies, who live in the ... during pregnancy to 3 - 6 times during pregnancy instead of ... ,However, these women are not more at risk than women ... baby, or have anemia during pregnancy, or spend longer in the ...
... Genetic variations in the HIV strains in Africa make it more ... to researchers. This however does not mean that these drugs will ... to latch on to the protease, which is an enzyme useful ... the drug attaches itself to the protease, then it is easier ...
Cached Medicine News:Health News:The World Bank funds private Hospital in India 2
(Date:10/17/2014)... Conn. , Oct. 17, 2014  UBM Medica ... online community for endocrinologists and other clinicians who treat ... comprehensive coverage on effective use of insulin .  ... eventually require insulin replacement therapy – daily ... for the progressive decline in the function of pancreatic ...
(Date:10/17/2014)...  Ameritox SM , the nation,s leader in medication ... Smith , M.D., as Chief Medical Officer. In this ... resources for healthcare providers, patients and managed care plans. ... a variety of healthcare companies that have provided him ... behavioral health sides of Ameritox,s business. He most recently ...
(Date:10/17/2014)... Oct. 17, 2014   ndd Medical Technologies , ... employing precise ultrasound technology, announced that its EasyOne Pro® ... Healthcare Center , a 140,000 square foot, 44-bed hospital ... hospital serves a large number of Native ... Oklahoma and beyond. A portion of its ...
Breaking Medicine Technology:Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3Ameritox Appoints New Chief Medical Officer 2EasyOne Pro Mobile Respiratory Testing from ndd Medical Technologies Chosen by Choctaw Nation 2
... 18, 2011 The U.S. Food and Drug Administration ... treat patients with acute lymphoblastic leukemia (ALL), who have ... derived asparaginase and pegaspargase chemotherapy drugs used to treat ... Acute lymphoblastic leukemia is a type of ...
... and OXFORD, England, Nov. 18, 2011   EUSA Pharma, a ... supportive care and critical care, today announced that ... approved its orphan drug ERWINAZE™ (asparaginase Erwinia ... leukemia (ALL) in patients with hypersensitivity to ...
Cached Medicine Technology:FDA Approves Erwinaze to Treat a Form of Leukemia 2FDA Approves Erwinaze to Treat a Form of Leukemia 3EUSA Pharma Announces FDA Approval of Orphan Drug ERWINAZE™ for Treatment of Acute Lymphoblastic Leukemia 2EUSA Pharma Announces FDA Approval of Orphan Drug ERWINAZE™ for Treatment of Acute Lymphoblastic Leukemia 3EUSA Pharma Announces FDA Approval of Orphan Drug ERWINAZE™ for Treatment of Acute Lymphoblastic Leukemia 4
... are available in 14 configurations including the ... Microgenics Antibody Technology, the SureStep MDMA (Ecstasy) ... immunoassay targeted to detect MDMA that has ... but no cross-reactivity to any isomer of ...
... Tests are available in 14 configurations including ... using Microgenics Antibody Technology, the SureStep™ MDMA ... care immunoassay targeted to detect MDMA that ... MDEA but no cross-reactivity to any isomer ...
AccuSign DOA Series tests include tests for Amphetamines, Barbituates, Benzodiazepines, Cocaine, Methadone, Methamphetamines, Nicotine (Cotinine), Opiates, Phencyclidine, THC, Tricyclic Antidepressan...
... The InstaCheck® multi-drug test device ... and easily. Negative results can ... as 3 minutes; positive results ... simple, one-time urine sample application ...
Medicine Products: